2001 Krebs Lecture
2001 Edwin G. Krebs Lectureship in Molecular Pharmacology
The Fourteenth Annual Edwin G. Krebs Lecture in Molecular Pharmacology
Sponsored by an endowment from Sterling Winthrop, Inc.
Protein Modules in Signal Transduction and the Cell Cycle
by: Anthony J. Pawson, Ph.D.
Full Professor, University of Toronto
Head, Program in Molecular Biology and Cancer
Samuel Lunenfeld Research Center
Wednesday, May 16, 2001
3:30 PM, Room T-625 HSC
Dr. Anthony Pawson is Head of the Program in Molecular Biology & Cancer and Acting Director at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Professor in the Department of Molecular & Medical Genetics, and University Professor of the University of Toronto. Dr. Pawson received an M.A. in Biochemistry from the University of Cambridge, England. He did his graduate training at the Imperial Cancer Research Fund, working with Dr. Alan Smith on the expression of retroviral gene products, and received his Ph.D. in 1976 from King's College, University of London. He pursued postdoctoral work at the University of California at Berkeley, with Drs. Peter Duesberg and Steven Martin, investigating the biochemical functions of retroviral oncogenes and their role in neoplastic cell transformation. In 1981, he was appointed Assistant Professor at the University of British Columbia, and in 1985 moved to the Samuel Lunenfeld Research Institute of Mt. Sinai Hospital, Toronto.
Protein tyrosine kinases are crucial regulators of cell growth and division and many other processes. Their specificity of phosphorylation of substrates is largely determined by direct association. In the 1980's, Dr. Pawson discovered the SH2 and SH3 domains that direct protein-protein interactions of the src family of cytosolic protein tyrosine kinases and many other signal transduction proteins. His work on this family of proteins has become a paradigm for specifically targeted signal transduction. At present, nearly all signal transduction pathways are thought to be specifically targeted within the cell, using protein-protein interactions to guide the flow of regulatory information. Dr. Pawson's recent work demonstrates the importance of these protein interactions in regulation of cell growth and neoplastic transformation, insulin action, immune surveillance, and neural information processing.
Dr. Pawson is a Distinguished Scientist of the Canadian Institutes for Health Research, holds the Apotex Chair in Molecular Oncology, and is an International Research Scholar of the Howard Hughes Medical Institute. He has received a number of awards, including the Gairdner Foundation International Award (1994), the Robert L. Noble Prize from the National Cancer Institute of Canada (1995), the George Drummond Memorial Award (1996), the Boehringer-Mannheim Prize (1997), the Henry Friesen Award (1998), the AACR-Pezcoller International Award for Cancer Research (1998), the Dr. H.P. Heineken Prize for Biochemistry and Biophysics from the Royal Netherlands Academy of Arts and Sciences (1998), the Killam Prize for Medicine (2000) and the J. Allyn Taylor International Prize in Medicine (2000). He is a Fellow of the Royal Societies of London and Canada, and a recipient of the Order of Canada.