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2004 Krebs Lecture

2004 Edwin G. Krebs Lectureship in Molecular Pharmacology

The Seventeenth Annual Edwin G. Krebs Lecture in Molecular Pharmacology
Sponsored by an endowment from Sterling Winthrop, Inc.

The Control of Cell Cycle Transitions

by: Tim Hunt, Ph.D.
Principal Scientist, Cancer Research UK,
Clare Hall Laboratories

Tuesday, May 11, 2004
3:30 PM, Room T-625 HSC

Dr. Richard Timothy (Tim) Hunt is a Principal Scientist at Cancer Research UK, Clare Hall Laboratories near London. He received his B. A. degree in Natural Sciences in 1964 and his Ph. D. degree in Biochemistry in 1968 at Cambridge University for work on the control of hemoglobin synthesis with Professors A. Korner and A. Munro . After postdoctoral research with Dr. Irving London at the Albert Einstein College of Medicine, he returned to Cambridge as a Research Fellow and University Lecturer. He also served as Instructor in Embryology and Physiology at the Marine Biological Laboratories in Woods Hole for several summers from 1977 to 1983. He assumed his present position at Cancer Research UK in 1991.

Dr. Hunt is a leader in research on regulation of protein synthesis and on control of the cell cycle and cell division by peptide regulators. His early work focussed on regulation of protein synthesis by protein phosphorylation in reticulocytes and in sea urchin eggs. In 1983, he reported the discovery of the cyclins, peptide regulators that are synthesized and degraded with each cleavage in the developing sea urchin egg. Subsequent work showed that synthesis of cyclins is necessary for cells to enter mitosis and that degradation by cyclin-associated cdc2 protein kinases controls specific steps in the cell cycle. Thus, the cyclins and the cyclin-dependent protein kinases are the master regulators of DNA synthesis and cell division. These discoveries have had an enormous impact on our understanding of the control of cell division in normal and cancer cells.

In addition to his research, Dr. Hunt has co-authored two important textbooks--The Cell Cycle: An Introduction with Dr. Andrew Murray and Molecular Biology of the Cell: A Problems Approach with Dr. John Wilson.

Dr. Hunt has served as a member of EMBO Review Panels, several Scientific Advisory Boards, and the editorial boards of the Journal of Cell Science and Molecular Biology of the Cell. He is a Fellow of the Royal Society of London and the Academy of Medical Sciences of the U. K., a member of EMBO and Academia Europeae, and a Foreign Associate of the National Academy of Science of the U. S. A. His research has been recognized by numerous awards including the French Legion of Honor and, in 2001, the Nobel Prize in Physiology or Medicine, shared with Drs. Lee Hartwell and Paul Nurse.