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2008 Krebs Lecture

2008 Edwin G. Krebs Lectureship in Molecular Pharmacology

The Twenty-First Annual Edwin G. Krebs Lecture in Molecular Pharmacology
Sponsored by an endowment from Sterling Winthrop, Inc.

Cell Signaling in Space & Time

by: John D. Scott, Ph.D.
Oregon Health Sciences University

Tuesday, June 3, 2008
4:30 PM, Room T625 HSC

Dr. John Scott is Professor of Biochemistry & Molecular Biology, Member of the Vollum Institute, and Investigator of the Howard Hughes Medical Institute at Oregon Health & Science University. Scott received his Ph. D. degree in Biochemistry at the University of Aberdeen in Scotland and did his postdoctoral studies with Dr. Edwin Krebs in the Department of Pharmacology at the University of Washington. He was appointed Assistant Professor of Physiology & Biophysics at the University of California at Irvine in 1988 and moved to Oregon Health & Science University as Assistant Member of the Vollum Institute and Assistant Professor of Biochemistry & Molecular Biology in 1990.

Dr. Scott is a leading investigator of the scaffolding proteins that organize the regulatory effects of protein kinases and phosphoprotein phosphatases within the cell. Using a novel assay for proteins that interact with the regulatory subunit of cyclic AMP-dependent protein kinase (PKA), Scott discovered the diversity of A Kinase Anchoring Proteins (AKAPs), revealed the molecular mechanism for their anchoring of PKA, and proposed that this family of related scaffolding proteins is responsible for the localization and signaling specificity of protein kinases. His subsequent work has amply demonstrated this concept and has added several new dimensions. AKAPs at synapses coordinate regulation of synaptic transmission. AKAPs in the cytoskeleton organize regulation of cell motility. AKAPs not only bind PKA, but also coordinate the localization of other protein kinases, phosphoprotein phos-phatases, and cyclic nucleotide phosphodiesterases. His work has made a major contribution to understanding the specificity of cell signaling in cellular regulation and molecular pharmacology.

Dr. Scott has served as an Editorial Board Member of the Journal of Biological Chemistry, as Reviews Editor of the Biochemical Journal, and as a member of several NIH Study Sections. He has chaired many international meetings and served on several advisory boards. His research accomplish-ments and mentoring of junior colleagues have been recognized by election to the Royal Society of London and by receipt of the John Jacob Abel Award of the American Society for Pharmacology & Experimental Therapeutics, the Ernst Oppenheimer Award of the Endocrine Society, and the William C. Rose Award of the American Society of Biochemistry & Molecular Biology.