The Edwin G. Krebs Lectureship in Molecular Pharmacology
The Twenty-Seventh Annual Edwin G. Krebs Lecture in Molecular Pharmacology
Sponsored by an endowment from Sterling Winthrop, Inc.
Cracking CRAC, the Store-Operated Calcium Channel in T Lymphocytes
by: Dr. Michael Cahalan
Professor and Chair
Physiology & Biophysics
School of Medicine
University of California, Irvine
Tuesday, May 20, 2014
2:30 PM, T-739, Health Sciences
About the Lectureship
The goal of research in molecular pharmacology is to understand the action of hormones and drugs on the molecular components of their target cells. Dr. Edwin G. Krebs, Emeritus Professor of Pharmacology and Biochemistry and Emeritus Investigator of the Howard Hughes Medical Institute, is a pioneer in unraveling the complex pathways by which hormones and drugs regulate cellular functions. In 1955, Dr. Krebs and Dr. Edmond Fischer, working in the Department of Biochemistry at the University of Washington, discovered the process of protein phosphorylation as the final chemical reaction in the hormonal pathway that regulates metabolism of glycogen, a complex carbohydrate used as an energy storage molecule in cells. The enzyme that carries out this chemical reaction, phosphorylase kinase, was the first example of a protein kinase, a family of enzymes now known to be the most important regulators of cell function. In further studies of this process in 1968, Dr. Krebs and his associates discovered a new enzyme, called cyclic AMP-dependent protein kinase, which mediates nearly all of the myriad actions of cyclic AMP regulation of cellular function by hormones and drugs. In recent years, members of the protein kinase enzyme family have been shown to be important in the action of an increasing number of hormones and drugs, as well as in regulation of cell growth, development, and malignant transformation, and in learning and memory in the nervous system. The pioneering discovery of protein phosphorylation by Drs. Krebs and Fischer led to the receipt of the Nobel Prize for Physiology for Medicine in 1992.
During his outstanding career, Dr. Krebs has been Professor of Biochemistry at the University of Washington and Professor and Chairman of the Department of Biological Chemistry at the University of California, Davis from 1968 to 1977. As the second Chairman of the Department of Pharmacology at the University of Washington, from 1977 to 1984, Dr. Krebs led a major expansion of research in molecular pharmacology at this university. The Edwin G. Krebs Lectureship in Molecular Pharmacology is intended to recognize Dr. Krebs' major achievements in research and administration in the field of molecular pharmacology and to stimulate at the University further development of this area of excellence.