1989 Krebs Lecture
1989 Edwin G. Krebs Lectureship in Molecular Pharmacology
The Second Annual Edwin G. Krebs Lecture in Molecular Pharmacology
Sponsored by an endowment from the Sterling Research Group
The Insulin Receptor and Insulin Action
Ora Mendelshon Rosen, Ph.D.
Professor, Departments of Molecular Biology, Sloan-Kettering Cancer Center
Wednesday, June 8, 1989
3:30 PM, Room T-625 HSC
Dr. Rosen is a leading investigator of protein kinases and of hormone receptors that are tyrosine protein kinases. Her early work helped to establish the mechanism of activation of cAMP-dependent protein kinase by cyclic AMP and to demonstrate the broad range of regulatory processes in which that enzyme participates. Dr. Rosen's recent studies have focused on the receptors for insulin and their mechanism of regulation of cell function. Dr. Rosen and her colleagues have isolated the insulin receptor protein, cloned the gene for this receptor protein, and determined its primary structure. An essential role for protein phosphorylation in insulin action has been demonstrated by her work showing that the insulin receptor itself is a protein kinase which phosphorylates substrate proteins on tyrosine, that activation of the receptor results in characteristic changes in the level of phosphorylation of key cellular proteins including the insulin receptor itself and that block of the tyrosine kinase activity by specific mutations prevents receptor mediated regulatory events. This work has laid a strong foundation for current experiments directed toward defining the pathways of insulin action. Dr. Rosen's work exemplifies the goal of research in molecular pharmacology to provide insight into the molecular basis for the actions of hormones and drugs.
Dr. Rosen received an M.D. degree from Columbia College of Physicians and Surgeons and was a clinical and research fellow at Albert Einstein College of Medicine. She was Professor of Medicine and Molecular Biology and Professor and Chairman of the Department of Molecular Pharmacology at Albert Einstein before taking her present position at Sloane-Kettering. She has been a member of the editorial boards of the Journal of Biological Chemistryand the Annual Review of Biochemistry. Her research contributions have been recognized by her selection for numerous distinguished lectureships and awards, including the Joseph Mather Smith Prize of the Columbia College of Physicians and Surgeons and the Louis and Beth Freedman Foundation Award of the New York Academy of Sciences.