1993 Krebs Lecture
1993 Edwin G. Krebs Lectureship in Molecular Pharmacology
The Sixth Annual Edwin G. Krebs Lecture in Molecular Pharmacology
Sponsored by an endowment from the Sterling Research Group
Dissection of the Protein Kinase Cascades involved in Insulin and Nerve Growth Factor Action
Philip Cohen, Ph.D.
Royal Society Research Professor, Department of Biochemistry, University of Dundee
Wednesday, April 23, 1993
3:30 PM, Hogness Auditorium
Dr. Cohen is a pioneer in the study of cellular regulation by protein phosphorylation and dephosphorylation. His early work made major contributions to understanding the complex regulation of the skeletal muscle enzyme glycogen synthase by phosphorylation at multiple sites by different protein kinases and its regulation by calcium and other second messengers. Using glycogen synthase as a well-defined substrate, he identified and characterized the multiple classes of phosphoprotein phosphatases which dephosphorylate the enzyme and developed the most widely used classification of the members of the family of phosphoprotein phosphatases. This work provided a model for unraveling the complex pathways of dephosphorylation of proteins in many cell types. Dr. Cohen has now cloned the genes for the major families of phosphoprotein phosphatases and established the principal primary, structural features of this family of enzymes. His most recent work focuses on the role of protein phosphorylation and dephosphorylation reactions in the regulatory pathways activated by growth factors insulin and nerve growth factor.
Dr. Cohen received his Ph.D. in Biochemistry from University College, London. Following postdoctoral study at the University of Washington with Dr. Edmond Fischer, Dr. Cohen joined the Department of Biochemistry at the University of Dundee where he has served as Director of the Medical Research Council Protein Phosphorylation Group and is now Royal Society Research Professor. Dr. Cohen has been editor and editorial board member of several journals including FEBS Letters, EMBO Journal, and Biochemical Journal and is now the managing editor of Biochimica Biophysica Acta. He is a fellow of the Royal Society of London and the Royal Society of Edinburgh and a member of the European Molecular Biology Organization and the Academia Europaea. His research has been recognized by selection for numerous distinguished lectureships and awards including the FEBS Anniversary Prize and Colworth Medal and the CIBA Medal and Prize of the British Biochemical Society.