1997 Krebs Lecture
1997 Edwin G. Krebs Lectureship in Molecular Pharmacology
The Tenth Annual Edwin G. Krebs Lecture in Molecular Pharmacology
Sponsored by an endowment from Sterling Winthrop, Inc.
Signaling by Protein-Tyrosine Kinases and Phosphatases
Tony Hunter, Ph.D.
Professor, Molecular Biology and Virology Laboratory, The Salk Institute , Adjunct Professor, Department of Biology, University of California, San Diego
Wednesday, June 4, 1997
3:30 PM, Room T-625 HSC
Dr. Tony Hunter is a leader in the study of regulation of cell growth and division by protein phosphorylation. He attended Caius College at the University of Cambridge, receiving his B.A. in 1965, and did his graduate studies in the Department of Biochemistry at the University of Cambridge under the supervision of Asher Korner, receiving his Ph.D. in 1969 for work on mammalian protein synthesis. He was appointed Research Fellow of Christ's College at the University of Cambridge in 1968 and then joined the Salk Institute as a Research Associate in 1971. He spent 1973 to 1975 back at the Department of Biochemistry at the University of Cambridge investigating how tobacco mosaic virus expresses its coat protein, before joining the Salk Institute as Assistant Professor in 1975. At that time he set out to identify tumor virus transforming gene products, starting with the tumor (T) antigens of polyoma virus and then turning his attention to Rous sarcoma virus (RSV). In the course of studying the polyoma virus middle T Antigen and the RSV v-Src gene product, he discovered that these proteins both have a previously unknown protein kinase activity that phosphorylates tyrosine. He has spent most of the last fifteen years studying protein-tyrosine kinases and their role in cell growth, oncogenesis, and the cell cycle. His major current interests are the protein-tyrosine kinases of the Src and growth factor receptor families, and the protein-tyrosine phosphatases that remove the phosphates added by protein-tyrosine kinases. His group also studies the cyclin-dependent protein kinases that regulate progression through the cell cycle.
Dr. Hunter is on the editorial boards of Cell, Molecular Biology of the Cell, Journal of Virology, and Current Biology, and serves on a number of scientific review and advisory committees. He was elected Fellow of the Royal Society of London in 1987, Fellow of the American Academy of Arts and Sciences in 1992, and Associate Member of the European Molecular Biology Organization in 1992, and was also appointed as an American Cancer Society Research Professor in 1992. He has received a number of awards for his work in the area of growth control, oncogenesis and protein phosphorylation, including the 1994 General Motors Cancer Research Foundation Mott Prize, a 1994 Gairdner Foundation International Award, and the Biochemical Society 1994 Hopkins Memorial Lectureship and Medal.