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1999 Krebs Lecture

1999 Edwin G. Krebs Lectureship in Molecular Pharmacology

The Twelfth Annual Edwin G. Krebs Lecture in Molecular Pharmacology
Sponsored by an from endowment Sterling Winthrop, Inc.
Elementary and Global Aspects of Calcium Signaling
Michael J. Berridge, Ph.D.
Deputy Chief Scientific Officer, Laboratory of Molecular Signaling, The Babraham Institute; Honorary Professor of Cel Signaling, University of Cambridge

Wednesday, March 29, 1999
3:30 PM, Room T-625 HSC

Dr. Michael J. Berridge is best known for his discovery of the second messenger inositol trisphosphate (IP 3), which plays a universal role in regulating cellular processes including cell growth and synaptic transmission. His studies on cell signaling began with research on control of fluid secretion by an insect salivary gland. A role for second messengers in controlling secretion was first recognized when cyclic AMP was found to mimic the stimulatory action of 5-hydroxytryptamine. Subsequent studies revealed the integrated action of the cyclic AMP and calcium messenger systems and showed that signal calcium could be derived from both external and internal reservoirs. In collaboration with John Fain, he provided the first direct evidence to support Robert Michell's hypothesis that hydrolysis of inositol lipids played a role in calcium signaling. Berridge then developed the new approach of measuring the formation of inositol phosphates directly, demonstrated that 5-hydroxytryptamine stimulated rapid formation of IP 3, and proposed that this metabolite might function as a second messenger. Such a messenger role was rapidly verified when IP 3 was found to mobilize calcium when added to permeabilized cells or injected into intact cells, and this calcium response has now been found to be important in intracellular regulation in nearly all cell types. Berridge's pioneering work opened the way for studies which showed that this novel signaling pathway mediates the actions of many hormones, neurotransmitters and drugs, establishing the IP 3 regulatory pathway as one of the most important in cell physiology and molecular pharmacology

Dr. Berridge received his B.Sc. in zoology and chemistry at the University College of Rhodesia and Nyasaland in 1960 and his Ph.D. degree for research in insect physiology with Sir Vincent Wigglesworth at the University of Cambridge in 1964. After postdoctoral research at the University of Virginia and Case Western Reserve University, Berridge returned to Cambridge to take up an appointment at the AFRC Unit of Insect Neurophysiology and Pharmacology in 1969. He is currently Scientific Director at The Babraham Institute Laboratory of Molecular Signaling in Cambridge and an Honorary Professor at the University of Cambridge. He is a Fellow of Trinity College and of The Royal Society. He has received numerous awards including The King Faisal International Prize in Science, The Louis Jeantet Prize in Medicine, The Albert Lasker Medical Research Award, The Heineken Prize for Biochemistry and Biophysics and The Wolf Foundation Prize in Medicine. In 1998, Berridge was knighted for his service to science.