Additional Neurological Effects Publications

Keifer MC, Firestone J. Neurotoxicity of pesticides. J Agromedicine. 2007 Dec;(1):17-25. PMID: 18032333.

Miranda J, Lundberg I, McConnell R, Delgado E, Cuadra R, Torres E, Wesseling C, Keifer M. Onset of Grip- and pinch- strength impairment after acute poisonings with organophosphate insecticides. Int J Occup Environ Health. 2002;8(1):19-26.

Wesseling C, Keifer M, Ahlbom A, McConnell R, Moon J-D, Rosenstock L, Hogestedt C. Long-term Neurobehavioral effects of mild poisonings with organophosphate and n-methyl Carbamate Pesticides among banana workers. Int J Occup Environ Health. 2002;8(1):27-34.

Engel L, Checkoway H, Keifer M, Seixas N, Longstreth W, Anger K, Camicioli R. Parkinsonism and occupational exposure to pesticides. Occup Environ Med. 2001;8(9):582-9. NIH Abstract and Full Article

McConnell R, Delgado E, Cuadra R, Torres E, Keifer M, Almend J, Miranda J, Lotti M, Moretto A, El-Fawal H, Wolff M, Simpson D, Lundberg I. Organophosphate neuropathy due to methamidophos: biochemical and neurophysiologic markers. Ach Tox. 1999;73(6):296-300.

Engel LS, Keifer MC, Checkoway H, Robinson LR, Vaughan TL. Neurophysiological function in farm workers exposed to organophosphate pesticides. Arch Environ Health. 1998;53(1):7-13. 

Keifer MC, Mihuran RK. Chronic neurological effects of pesticide overexposure. Occupational Medicine State of the Art Reviews. 1997;12(2):291-304. 

Fiedler N, Kipen H, Kelly-McNeil K, Fenske RA. Long-term use of organophosphates and neuropsychological performance. Am J Ind Med. 1997;32:487-496. 

Keifer MC (ed). Human Health Effects of Pesticides. Occupational Medicine State of the Art Reviews. 1997:12(2). n/a

Davies H, Richter R, Keifer MC, Broomfield CA, Furlong CE. The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nature Genetics. 1996;14:334-336.

Neurobehavioral Assessment of Pesticide Exposure in Children (NIOSH/CDC, 2006-2011)

The objective of this project based at Oregon Health Sciences University was to identify and characterize OP exposure in the homes of pesticide mixer-loader applicators and to relate those exposures to neurobehavioral performance of children of pesticide applicators over two years in a longitudinal study that examinee neurodevelopmental changes.

There is increasing concern that the widespread use of pesticides in agriculture may be affecting farmworker communities, thus a potential public health problem. Agricultural workers are at risk of pesticide exposure from occupational exposures and they and their family are at risk of exposures in the home. Detectable levels of pesticides have been reported in home dust, primarily in families residing in agricultural areas. Studies have also documented the presence of biological markers of pesticide exposure in adults and children and there are higher levels of exposure in residents of agricultural communities when compared to non-agricultural communities. Neurobehavioral tests have identified deficits in adult populations exposed to and poisoned by OP pesticides. However, little research has examined the impact on children.

Our previous work provides preliminary evidence of health effects associated with chronic exposure to pesticides in adult farmworkers. However, the absence of exposure and biological data from the non-agricultural group limit the conclusions. These results need to be replicated and extended to children who are a more vulnerable population.

Publication List

Rohlman, D. Neurobehavioral Effects of Pesticide Exposure in Children. MNC Streamline


Measuring Pesticide Exposure in Children Living in an Ag Community

 2011 Symposium on Agriculture, Forestry, and Fishing Health and Safety
PowerPoint Presentation

Neurological Effects of Organophosphorus Insecticides in Farmworkers (NIOSH/CDC, 1993-2000)

The overall goal of this study was to determine whether farm workers who thin fruit trees exhibit neurological changes following one season of exposure to low levels of organophosphorus insecticides compared to workers who were not exposed. Data were collected 97 in follow-up testing. A wide ranging number of tests, including peripheral and central nervous system function, were applied to both groups. Cholinesterase was measured both after the exposure season and after the period of non-exposure. Cross-sectional analysis of peripheral neurological outcomes after exposure revealed that there were no significant differences between exposed and non-exposed farm workers.