Moira L. Aitken, MD
Professor, Division of Pulmonary and Critical Care Medicine
University of Washington Medical Center
1959 N.E. Pacific, Campus Box 356522
Seattle, WA 98195-6522
Research Web Page
Academic Office: (206) 543-3166
Fax: (206) 685-8673
Clinic Appointments: (206) 598-4615
Education and Training
B.Sc. (Medical Science), Edinburgh University Medical School, Edinburgh, Scotland, 1975.
M.B.Ch.B., merit certificates awarded in Chemistry, Forensic Medicine, Edinburgh University Medical School, Edinburgh, Scotland, 1978.
M.D., Edinburgh University Medical School, Edinburgh, Scotland, 1992.
Internship in Internal Medicine, Western General Hospital, and Royal Infirmary Hospital, Edinburgh, Scotland, 1979.
Residency in Internal Medicine, Western General Hospital, Northern General Hospital and Royal Infirmary Hospital, Edinburgh, Scotland, 1982.
Fellowship in Pulmonary Medicine, University of Washington, Seattle, WA, 1985.
Overall objectives are to understand the mechanisms of airway inflammation and infection in cystic fibrosis (CF). The CF gene product, CFTR, leads to airway inflammation though a series of abnormalities, including hypertonicity of periciliary fluid encouraging bacterial growth, altering airway adhesion molecules, and altering a variety of intracellular protein trafficking. She is also involved in Phase I and II clinical trials and in epidemiological studies of CF.
McKone EF, Emerson SS, Edwards KL, Aitken ML. Effect of genotype on phenotype and mortality in cystic fibrosis: a retrospective cohort study. Lancet. 2003 May 17;361(9370):1671-6.
Aitken ML, Greene KE, Tonelli MR, Burns JL, Emerson JC, Goss CH. Analysis of sequential aliquots of hypertonic saline solution-induced sputum from clinically stable patients with cystic fibrosis. Chest. 2003 Mar;123(3):792-9.
Ordonez CL, Henig NR, Mayer-Hamblett N, Accurso FJ, Burns JL, Chmiel JF, Daines CL, Gibson RL, McNamara S, Retsch-Bogart GZ, Zeitlin PL, Aitken ML. Inflammatory and microbiologic markers in induced sputum after intravenous antibiotics in cystic fibrosis. Am J Respir Crit Care Med. 2003 Dec 15;168(12):1471-5.
Goss CH, Rubenfeld GD, Otto K, Aitken ML. The effect of pregnancy on survival in women with cystic fibrosis. Chest. 2003 Oct;124(4):1460-8.
Mayer-Hamblett N, Rosenfeld M, Emerson J, Goss CH, Aitken ML. Developing cystic fibrosis lung transplant referral criteria using predictors of 2-year mortality. Am J Respir Crit Care Med. 2002 Dec 15;166(12 Pt 1):1550-5.