Peter Chen, MD
Affiliate Associate Professor
Division of Pulmonary and Critical Care Medicine
Education and Training
BS, Electrical Engineering, The University of Texas at Austin, 1994.
MD, Baylor College of Medicine, Houston, TX 1999.
Internship, Internal Medicine, University of Texas at Southwestern Medical Center, Dallas, TX 2000.
Residency, Internal Medicine, University of Texas at Southwestern Medical Center, Dallas, TX 2002.
Fellowship, Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 2005.
My lab focuses on how the lung epithelium interacts with the matrix during injury and repair. A major focus has been basic research into mechanisms regulating airway epithelial cell migration using in vitro and in vivo mouse models of airway injury. We have been working on understanding how syndecan-1, a cell surface proteoglycan, regulates epithelial repair after injury. Our work has defined a mechanism by which syndecan-1 controls focal adhesion turnover and integrin activation during lung epithelial migration. We have now taken that work and extended it into pathological conditions such as lung cancer and lung infections and finding that syndecan-1 has multiple roles in regulating and limiting the severity of lung disease. In a separate project, my lab has a line of investigation into how microRNAs participate in airway repair and fibrosis. This project takes a translational approach by using human airway epithelial cells procured from lung transplant patients. Our goal is to identify putative microRNAs that participate in the pathophysiology of chronic rejection after lung transplantation (i.e., obliterative bronchiolitis).
Chen P, Farivar AS, Mulligan MS, Madtes DK. TIMP-1 Deficiency Abrogates Obliterative Airway Disease after Heterotopic Tracheal Transplantation. Amer J. Resp. Cell Mol. Biol 2006 ; 34(4) :464-472. (PMID: 16388023)
Chen P, McGuire JK, Hackman RC, Kim KH, Black RA, Poindexter K, Yan W, Liu P, Chen AJ, Parks WC, Madtes DK. Tissue Inhibitor of Metalloproteinase-1 Moderates Airway Re-epithelialization by Regulating Matrilysin Activity. Am J Pathol. 2008; 172:1256-70. (PMID: 18385523)
Chen P, Parks WC. The Role of Matrix Metalloproteinases in Epithelial Cell Migration. J Cell Biochem. 2009; 108:1233-43. (PMID: 19798678)
Chen P, Abacherli LA, Nadler ST, Wang Y, Li Q, Parks WC. Matrilysin Shedding of Syndecan-1 Facilitates Re-epithelialization by Affecting a2b1 Integrin Activation. PLoS ONE. 2009. 4(8): e6565. (PMID: 19668337)
Altemeier WA, Schlesinger SY, Buell CA, Parks WC, Chen P. Syndecan-1 Controls Cell Migration by Activating Rap1 to Regulate Focal Adhesion Disassembly. J Cell Sci. 2012. In Press.
Altemeier WA, Schlesinger SY, Buell CA, Rapraeger AC, Parks WC, Chen P. The transmembrane and extracellular domains of syndecan-1 have distinct functions in regulating lung epithelial migration and adhesion. J Biol Chem. 2012. In Press.