Sina Gharib, M.D.

Sina Gharib, MD

Associate Professor
Division of Pulmonary, Critical Care & Sleep Medicine

Contact Information

Harborview Medical Center
NJB - 416 Ninth & Jefferson Bldg.
Campus Bos 359803, Seattle WA 98104
or --
Center for Lung Biology (CLB)
S376 - 815 Mercer,
Campus Box 385052, Seattle WA 98109

Sina Gharib
Academic Office: CLB - (206) 221-0630
Fax: CLB - (206) 221-0739
Research Web Page

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Education and Training

B.S. in Electrical Engineering, University of California Los Angeles, 1992.

M.D., Harvard Medical School, Boston Massachusetts, 1996.

Residency, Internal Medicine, University of Washington, Seattle, Washington 1999.

Fellowship, Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington, 2006.

Fellowship, Sleep Medicine, University of Washington, Seattle, Washington, 2008.

ACLS certified

Research Interests

My overall research goal is to understand the pathogenesis of complex phenotypes using genomic, transcriptomic and proteomic analyses. While the focus of my current research is pulmonary and sleep related disorders, the long-term aim of our program is to develop computationally-driven methods that are applicable to a wide-range of clinically significant diseases.

Representative Publications

Gharib SA, Liles WC, Klaff L, Altemeier WA. Non-injurious Mechanical Ventilation Activates a Pro-inflammatory Transcriptional Program in the Lung. Physiological Genomics. 37(3): 239-48, 2009.

Gharib SA, Vaisar T, Aitken ML, Park DR, Heinecke JW, Fu X. Mapping the Lung Proteome in Cystic Fibrosis. Journal of Proteome Research. 8(6):3020-8, 2009.

Becker L, Gharib SA, Irwin AD, Wijsman E, Vaisar T, Oram JF, Heinecke JW. A macrophage sterol-responsive network linked to atherogenesis. Cell Metabolism 2010 Feb; 11; 2; 125-35.

Hancock DB*, Eijgelsheim M*, Wilk JB*, Gharib SA*, Loehr LR, Marciante KD, Franceschini Nora, van Durme Y, Chen T, Barr RG, Schabath MB, Couper DJ, Brusselle GG, Psaty BM, van Duijn CM, Rotter J, Uitterlinden AG, Hofman A, Punjabi NM, Rivadeneira F, Morrison AC, Enright PL, North KE, Heckbert SR, Lumley T, Stricker B, O’Connor GT, London SJ. Meta-analyses of genome-wide association studies identify multiple novel loci related to pulmonary function: the CHARGE consortium. Nature Genetics. 2010 Jan; 42; 1; 45-52.

Khalyfa A*, Gharib SA*, Kim J, Dayyat E, Snow AB, Bhattacharjee R, Kheirandish-Gozal L, Goldman JL, Gozal D. Phosphatases as Novel Therapeutic Targets for Adenotonsillar Hypertrophy of Pediatric Sleep Apnea. American Journal of Respiratory and Critical Care Medicine. 2010 May; 181; 10; 1114-20.


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