Sean Gill, PhD
Division of Pulmonary and Critical Care Medicine
Education and Training
B.Sc. in Physiology, Dept. of Physiology and Pharmacology, University of Western Ontario, London, Ontario, 2000.
Ph.D. in Physiology, Dept. of Physiology and Pharmacology, University of Western Ontario, London, Ontario, 2005.
Postdoctoral Fellow, Dept. of Physiology and Pharmacology, University of Western Ontario, London, Ontario, 2006
Postdoctoral Fellow, Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, 2010.
Research in my laboratory focuses on the resolution of inflammation following lung injury. In particular, our work has centered on examining the role of tissue inhibitor of metalloproteinases 3 (TIMP3) in leukocyte recruitment to the lung following injury. We have determined that TIMP3 serves to restrict ongoing neutrophil influx during the repair process, and is thereby integral to the resolution of inflammation. Currently, we are using in vivo and in vitro techniques to establish how TIMP3 mediates this process. One potential mechanism is through the control of macrophage polarization. Other research interests include examining the role of endogenous sulfated glycosaminoglycans in controlling leukocyte activation following lung injury or infection.
Gill S.E., Wight T.N., and Frevert C.W. (2010) Proteoglycans: Key Regulators of Pulmonary Inflammation and the Innate Immune Response to Lung Infection. Anat Rec (Hoboken). 293(6): 968-81.
Tanino Y., Coombe D.R., Gill S.E., Kett W.C., Kajikawa O., Proudfoot A.E.I., Wells T.N.C., Wight T.N., Martin T.R., and Frevert C.W. (2010) Kinetics of Chemokine-Glycosaminoglycan Interactions Control Neutrophil Migration into the Airspaces of the Lungs. J Immunol. 184(5): 2677-85.
Gill S.E., Huizar I., Bench E.M., Sussman S.W., Wang Y., Khokha R., and Parks W.C. (2010) Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury. Am J Pathol.176 (1): 64-73.
Gill S.E. and Parks W.C. (2008) Metalloproteinases and their inhibitors: Regulators of wound healing. Int J Biochem Cell B. 40: 1334-1347.
Gill S.E., Pape M.C., and Leco K.J. (2006) Regulation of extracellular matrix-cell signaling by tissue inhibitor of metalloproteinases-3 (TIMP-3) during murine bronchiole branching morphogenesis. Dev Biol. 298: 540-554.