richard b. goodman, md
Division of Pulmonary and Critical Care Medicine
Section Head, Veterans Affairs Puget Sound
Health Care System
Veterans Affairs Puget Sound Health Care System
1660 South Columbian Way
Seattle, WA 98108
Clinician-Educator Web Page
Academic Office: (206) 764-2504
Fax: (206) 764-2659
Clinic Appointments: (206) 764-2504 or
1-800-329-8387 (return patients)
(206) 764-2306 (new patients)
Education and Training
B.A. in Chemistry, St. Olaf College, Northfield, MN, 1976.
M.A. in Biochemistry, University of South Dakota, Vermillion, SD, 1980.
M.D., University of Oklahoma, Oklahoma City, OK, 1982.
Internship, Residency and Chief Residency in Internal Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK, 1982-1986.
Clinical Fellowship in Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, 1986-1987.
Research Fellowship in Pulmonary and Crtiical Care Medicine (Laboratory of Thomas R. Martin, M.D.), University of Washington, Seattle, WA, 1987-1989.
Visiting Scientist (protein chemistry); ZymoGenetics, Corp., (Laboratory of John W. Forstrom, Ph.D.) Seattle, WA, 1989-1990.
Visiting Scientist (molecular biology); ZymoGenetics, Corp., (Laboratory of Donald C. Foster, Ph.D.) Seattle, WA. 1991-1993.
The primary focus of this laboratory is the study of molecular mechanisms of lung inflammation. We are interested in defining the relative contribution made by neutrophils (PMN) to the pathological process of acute lung injury. Our goals are to identify the predominant signals produced by lung cells which recruit PMN from the blood stream (known as chemoattractants or chemokines), to define the dominant cell surface receptor(s) responsible for PMN migration, and to investigate strategies to block PMN migration in pre-clinical disease models of acute lung injury.
Cummings J, Martin TR, Frevert CW, Quan JM, Wong VA, Mongovin SM, Hagen TR, and Goodman RB. Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis. J Immunol, 162:2341-2346, 1999.
Goodman RB, Strieter RM, Frevert CW, Cummings JC, Tekamp-Olson P, Kunkel SL, Walz A, Martin TR. Quantitative comparison of CXC-chemokines produced by endotoxin-stimulated human alveolar macrophages. Am J Physiol: Lung Cell Molec Physiol (Submitted).
Frevert C, Wong VA, Goodman RB, Goodwin R, Martin TR. Rapid fluorescence-based measurement of neutrophil migration in vitro. J Immunol Methods 213:41-52, 1998.
Goodman RB, Strieter RM, Martin DP, Steinberg KP, Milberg JA, Maunder RJ, Kunkel SL, Walz A, Hudson LD, Martin TR. Inflammatory Cytokines in Patients with Persistence of the Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 154:602-611, 1996.
Quan JM, Martin TR, Rosenberg BG, Foster DC, Whitmore T, and Goodman RB. Antibodies Against the N-terminus of IL-8 Receptor A Inhibit Neutrophil Chemotaxis. Biochem Biophys Res Commun 219: 405-411, 1996.