teal hallstrand, md, mph
Division of Pulmonary and Critical Care Medicine
University of Washington Medical Center
1959 N.E. Pacific, Campus Box 356522
Seattle, WA 98195-6522
Academic Office: (206) 221-6506
Fax: (206) 685-8673
Clinic Appointments: (206) 598-4615
Education and Training
BS, Biochemistry, Humboldt Sate University, Arcata, CA, 1989
MD, University of Washington School of Medicine, Seattle, WA, 1993
Internship and Residency, Internal Medicine, Maine Medical Center, Portland, ME, 1993-1997
Fellowship, Pulmonary and Critical Care, University of Washington, Seattle, WA, 1997-2001
MPH, Epidemiology, University of Washington, School of Public Health and Community Medicine, Seattle, WA, 2001
My laboratory focuses on the pathogenesis of asthma through translational human studies and in vitro models using primary human cells. A major focus of our laboratory is on the regulation of a group of pro-inflammatory lipid mediators in the airways called eicosanoids (e.g. leukotrienes and prostaglandins). The increased production of these mediators plays a central role in the pathogenesis of exercise-induced bronchoconstriction (EIB), and is also strongly implicated in other aspects of asthma, especially acute asthma exacerbations triggered by allergen and viral infection. We are particularly interested in understanding how the airway epithelium regulates the production of these pro-inflammatory mediators by interacting with inflammatory cells such as mast cells and eosinophils that reside in close contact with the airway epithelium. Our research in this area has led to the identification of a key regulatory enzyme called secreted phospholipase A2 (PLA2) group X that has increased expression in asthma. My laboratory has ongoing collaborations with the laboratories of Drs. William Henderson (murine models of asthma), Michael Gelb (medical enzymology), and Jason Debley (pediatric asthma). It is our hope that this research will lead to targeted treatments for specific manifestation of asthma and new therapies for asthma.
Additional information about our ongoing clinical/translational asthma studies can be obtained by Emailing firstname.lastname@example.org (confidentiality cannot be guaranteed by Email).
Hallstrand TS, Curtis JR, Koepsell TD, Schoene RB, Sullivan SD, Yorioka GN, Aitken ML. Effectiveness of screening examinations to detect unrecognized exercise-induced bronchoconstriction. J Pediatr 2002; 141:343-348.
Hallstrand TS, Sprenger JD, Agosti JM, Longton GM, Witherspoon RP, Henderson WR, Jr. Long-term acquisition of allergen-specific IgE and asthma following allogeneic bone marrow transplantation from allergic donors. Blood 2004; 104:3086-90.
Hallstrand TS, Moody MW, Aitken ML, Henderson WR, Jr. Airway immunopathology of asthma with exercise-induced bronchoconstriction. J Allergy Clin Immunol 2005;116:586-593.
Hallstrand TS, Moody MW, Wurfel MM, Schwartz LB, Henderson WR, Jr., Aitken ML. Inflammatory basis of Exercise-induced bronchoconstriction. Am J Resp Crit Care Med 2005; 172:679-686.
Hallstrand TS, Fischer ME, Wurfel MM, Afari N, Buchwald D, Goldberg J. Genetic Pleiotropy between Asthma and Obesity in a Community-based Sample of Twins. J Allergy Clin Immunol 2005; 116:1235-41.
Hallstrand TS, Debley JS, Farin FM, Henderson WR, Jr. Role of MUC5AC in exercise-induced bronchoconstriction pathogenesis. J Allergy Clin Immunol 2007; 119:1092-8. Epub 2007 Feb 26.
Hallstrand TS, Chi EY, Singer AG, Gelb MH, Henderson Jr WR. Secreted phospholipase A2 group X overexpression in asthma and bronchial hyperresponsiveness. Am J Respir Crit Care Med. 2007 176: 1072-8. Epub 2007 Sep 27.