teal hallstrand, md, mph
Division of Pulmonary and Critical Care Medicine
University of Washington Medical Center
1959 N.E. Pacific, Campus Box 356522
Seattle, WA 98195-6522
Academic Office: (206) 221-6506
Fax: (206) 685-8673
Clinic Appointments: (206) 598-4615
Education and Training
BS, Biochemistry, Humboldt Sate University, Arcata, CA, 1989
MD, University of Washington School of Medicine, Seattle, WA, 1993
Internship and Residency, Internal Medicine, Maine Medical Center, Portland, ME, 1993-1997
Fellowship, Pulmonary and Critical Care, University of Washington, Seattle, WA, 1997-2001
MPH, Epidemiology, University of Washington, School of Public Health and Community Medicine, Seattle, WA, 2001
Current Research Interests
My laboratory studies the pathogenesis of asthma through translational human studies as well as in vitro models using primary human cells and selected in vivo models. We focus on two major areas 1) the regulation and function of a group of inflammatory lipid mediators called eicosanoids (e.g. leukotrienes and prostaglandins), and 2) the origin and function of mast cells in asthma. The release of mediators from mast cells and the increased production of lipid mediators play central roles in the pathogenesis of exercise-induced bronchoconstriction (EIB), and are also strongly implicated in other aspects of asthma, especially acute asthma exacerbations triggered by allergen and viral infection. We are particularly interested in understanding how the airway epithelium regulates the production of these inflammatory mediators by interacting with inflammatory cells such as mast cells and eosinophils that reside in close contact with the airway epithelium. Recent genome wide studies have identified several epithelial genes that may serve as primary regulators of the immune response leading to asthma. We recently worked with researchers from Benaroya Research Institute (BRI), the UW department of Immunology, and Seattle Children’s Research Institute (SCRI) to become part of the NIAID Asthma and Allergic Disease Cooperative Research Centers program. We have also had annual meetings with other researchers interested in Epithelial Biology for the past 8 years, including additional researchers from the Center for Lung Biology (CLB), Oregon Health and Science University (OHSU) and University of British Columbia (UBC). My lab also has strong ongoing collaborations with the section of Allergy and Clinical Immunology, and the medical enzymology program in Biochemistry of Dr. Michael Gelb (Gelb Lab) with a focus on the biology of lipid mediator formation. I have worked collaboratively with these scientists to cultivate a vibrant training environment for patient-oriented research through the development of biorepositories of tissue samples, airway fluid, and primary cells, and through state-of-the-art facilities including systems for quantitative morphometry using human tissue samples. We have developed unique resources for our studies including protocols to grow primary airway epithelial cells from subjects with different phenotypes of asthma in organotypic culture and co-culture model systems. It is my hope that this research will lead to a better understanding of the biology of asthma and the development of new therapies for asthma.
For more information about our annual Epithelial Biology meeting, please send me an (email).
Hallstrand TS, Wurfel MM, Lai Y, Ni Z, Gelb MH, Altemeier WA, Beyer RP, Aitken ML, Henderson WR Jr. Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes. PLoS One. 2010 5: e8583.
Lai Y, Oslund RC, Bollinger RC, Henderson WR, Jr., Santana L, Gelb MH, Hallstrand TS. Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X. J Biol Chem. 2010 285:41491-500. Epub 2010 Oct 25.
Gharib SA, Nguyen EV, Lai Y, Plampin JD, Goodlett DR, Hallstrand TS. Induced sputum proteome in healthy subjects and asthmatic patients. J Allergy Clin Immunol. 2011 128:1176-1184.e6. Epub 2011 Sep 8.
Hallstrand TS, Lai Y, Altemeier WA, Appel CL, Johnson B, Frevert CW, Hudkins KL, Bollinger JG, Woodruff PG, Hyde DM, et al. Regulation and function of epithelial secreted phospholipase A2 group X in asthma. Am J Respir Crit Care Med 2013;188:42-50.
Lai Y, Altemeier WA, Vandree J, Piliponsky AM, Johnson B, Appel CL, Frevert CW, Hyde DM, Ziegler SF, Smith DE, Henderson WR, Jr., Gelb MH, Hallstrand TS. Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33. J Allergy Clin Immunol. 2014 133:1448-55.
Hallstrand TS, Lai Y, Hooper KA, Oslund RC, Altemeier WA, Matute-Bello G, Gelb MH. Endogenous secreted phospholipase A group X regulates cysteinyl leukotrienes synthesis by human eosinophils. J Allergy Clin Immunol 2015; 137:268-277.
Nolin JD, Ogden HL, Lai Y, Altemeier WA, Frevert CW, Bollinger JG, Naika GS, Kicic A, Stick SM, Lambeau G, Henderson WR Jr, Gelb MH, Hallstrand TS. Identification of epithelial phospholipase A2 receptor 1 (PLA2R1) as a potential target in asthma. Am J Respir Cell Mol Biol. 2016 Jul 22. [Epub ahead of print]