David Horne, MD, MPH

David Horne, MD

Associate Professor
Division of Pulmonary, Critical Care & Sleep Medicine
Adjunct Assistant Professor of Global Health

Contact Information

Harborview Medical Center
325 - 9th Avenue
Seattle, WA 98104

Research Web Page
Academic Office: (206) 744-4689
Fax: (206) 744-8584



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Education and Training

B.A. in Human Biology/International Development, Stanford University, Stanford, CA, 1992.

M.D., University of California San Francisco, San Francisco, CA, 2000.

Internship, Internal Medicine, Yale-New Haven Hospital, New Haven, CT, 2001.

Residency, Internal Medicine, Yale-New Haven Hospital, New Haven, CT, 2003.

Chief Medical Resident, Internal Medicine, Yale-New Haven Hospital, New Haven, CT, 2004.

MPH in Epidemiology, University of Washington, Seattle, WA, 2009

Fellowship, Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, 2010.

ACLS certified

Research Interests

My research is focused on tuberculosis including genetic epidemiology of susceptibility, epidemiology, and best practices for its diagnosis and management in low resource settings. At present, I hold grants to prospectively investigate the role of human genetic variation in susceptibility to latent TB infection in a Seattle cohort and TB disease in a pediatric South African cohort. I am also studying the prevalence of active TB among HIV-1-infected pregnant women in western Kenya and cofactors associated with TB disease and latent infection. These efforts are supported by grants from the National Institutes of Health/National Institute of Allergy and Infectious Diseases, the American Thoracic Society, and the Firland Foundation.

Representative Publications

Horne DJ , Gooze L, Royce S, Narita M, Hopewell PC, Nahid P, Steingart KR. Sputum Monitoring During Tuberculosis Treatment for Predicting Outcome: A Systematic Review and Meta-Analysis, The Lancet Infectious Diseases, June 2010, 10(6); 387-94.

Horne DJ , Hubbard R, Narita M, Exarchos A, Park DR, Goss CH. Factors Associated with Mortality in Patients with Tuberculosis, BMC Infectious Diseases, 2010, 10; 258.

Horne DJ , Randhawa AK, Chau TTH, Bang ND, Hieu NT, Farrar JJ, Dunstan SJ, Hawn TR. Common Polymorphisms in the PKP3-SIGIRR-TMEM16J Gene Region Are Associated with Susceptibility to Tuberculosis. Journal of Infectious Diseases, 2012 Feb; 205(4): 586-594.

Baker AR, Qiu F, Randhaw AK, Horne DJ , Adams, MD, Shey M, Bamholtz-Sloan J, Mayanja-Kizza H, Kaplan G, Hanekom WA, Boom WH, Hawn TR, Stein CM. Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap Data. PLoS One, 2012 Oct; 7(10): e47597. doi:10.1371/journal.pone.0047597.

Horne DJ , Campo M, Ortiz JR, Oren E, Arentz M, Crothers K, Narita M. Association between smoking and latent tuberculosis in the U.S. population. PLoS One, in press.

Horne DJ , Pinto L, Arentz M, Lin SYG, Desmond E, Flores LL, Steingart KR, Minion J. Diagnostic Accuracy and Reproducibility of WHO-endorsed Phenotypic Drug Susceptibility Testing Methods for First- and Second-line Anti-tuberculosis Drugs: A Systematic Review and Meta-Analysis. Journal of Clinical Microbiology, in press.


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