a. McGarry Houghton, MD
Division of Pulmonary and Critical Care Medicine
Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N. (D4-191)
P.O. Box 19024
Seattle, WA 98109-1024
Academic Office: (206) 667-3175
Fax: (206) 667-576
Education and Training
BA (Chemistry), Johns Hopkins University, Baltimore, MD, 1992.
MD, Georgetown University School of Medicine, Washington, DC, 1996.
Intern, Internal Medicine, UT-Southwestern (Parkland Hospital), Dallas, TX, 1997.
Resident, Internal Medicine, UT-Southwestern (Parkland Hospital), Dallas, TX, 1999.
Fellow, Pulmonary & Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, 2004.
The broad focus of our group has been to study the role of inflammatory cell derived proteinases in diseases occurring within the lungs. To date, this has included novel findings for many disease processes including lung cancer, COPD/emphysema, acute lung injury, pulmonary infections, and pulmonary fibrosis. More recently, our focus has shifted to the tumor microenvironment. We are currently investigating the role of innate immune cells within the tumor microenvironment in a comprehensive fashion, beginning with how they have been recruited, and ending with a detailed understanding of the mechanism by which a specific immune cell effector has impacted lung tumor growth.
Houghton AM, Ji H, Mariani TJ, Perera S, Bender Kim C, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Shapiro SD, and Wong KK. K-ras activation generates an inflammatory response in lung tumors. Oncogene 2006, 25:2105-12.
Houghton AM, Quintero PQ, Perkins DL, Kobayashi DK, Kelley DG, Mecham RP, Senior RM, Shapiro SD. Elastin fragments drive disease progression in a murine model of emphysema. J Clin Invest 2006, 116:753-759.
Houghton AM, Grisolano JL, Baumann ML, Kobayashi DK, Cornelius LA, and Shapiro SD. Macrophage Elastase (MMP-12) Suppresses Growth of Lung Metastases. Cancer Res 2006, 66:6149-55.
Houghton AM, Mouded M, Shapiro SD. Common origins of Lung Cancer and COPD. Nature Med. 2008, 14:1023-4.
Houghton AM, Hartzell WO, Robbins CS, Gomis-Ruth FX, Shapiro SD. Macrophage elastase kills bacteria within murine macrophages. Nature. 2009, 460:637-641.
Houghton AM, Rzymkiewicz D, Ji H, Gregory A, Egea E, Metz HE, Stolz DB, Marconcini LA, Jenkins K, Beaulieu K, Mouded M, Frank SJ, Wong KK, Shapiro SD. Neutrophil Elastase-Mediated Degradation of IRS-1 Accelerates Lung Tumor Growth. Nature Med. 2010, 16:219-223.
Metz HE and Houghton AM. Insulin Receptor Substrate Regulation of Phosphoinositol-3 Kinase. Clin Cancer Res. 2010, 17:206-11.
Gregory AD and Houghton AM. Tumor associated neutrophils: new targets for cancer therapy. Cancer Res. 2011, 71:2411-16.