David K. Madtes, MD
Division of Pulmonary and Critical Care Medicine
Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N. (D3-190)
P.O. Box 19024
Seattle, WA 98109-1024
Academic Office: (206) 667-5120
Fax: (206) 667-5765
Education and Training
B.A. in Chemistry, Gettysburg College, Gettysburg, PA, 1974.
M.D. in Medicine, University of Pittsburgh, Pittsburgh, PA, 1979.
Internship at the University of Rochester, Strong Memorial Hospital, Rochester, NY, 1980.
Residency at the University of Rochester, Strong Memorial Hospital, Rochester, NY, 1982.
The focus of research is on the cellular and molecular mechanisms responsible for normal alveolar development and repair and for the fibroproliferative response that results in pulmonary fibrosis. Two primary projects: are 1) the identification of growth factors that regulate the cellular proliferation and extracellular matrix remodeling in the injured alveolus and in the developing lung; and 2) the identification of matrix metalloproteinases and tissue inhibitors of metalloproteinases responsible for extracellular remodeling in lung fibrosis.
Madtes DK, Raines EW, Sakariassen KS, Assoian RK, Sporn MB, Bell GI, and Ross R. Induction of transforming growth factor-alpha in activated human alveolar macrophages. Cell 53:285-293, 1988.
Strandjord TP, Clark JG, Hodson WA, Schmidt RA, Madtes DK. Expression of transforming growth factor-alpha in mid-gestation human fetal lung. Am J Respir Cell Mol Biol 8:266-272, 1993.
Madtes DK, Busby HK, Strandjord TP, Clark JG. Expression of transforming growth factor-alpha and epidermal growth factor receptor is increased following bleomycin induced lung injury in rats. Am J Respir Cell Mol Biol 11:540-551, 1994.
Madtes DK, Rubenfeld G, Klima LD, Milberg JA, Steinberg KP, Martin TM, Raghu G, Hudson LD, Clark JC. Elevated transforming growth factor-alpha levels in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Am J Resp Crit Care Med 158:424-430, 1998.
Madtes DK, Elston AL, Hackman RC, Dunn AR, Clark JG. Transforming growth factor-alpha deficiency reduces pulmonary fibrosis in transgenic mice. Am J Respir Cell Mol Biol 20:924-934, 1999.