Anne Manicone, MD

Associate Professor
Division of Pulmonary and Critical Care Medicine

Contact Information

Center for Lung Biology
S331 - 850 Republican Bldg.
Campus Box 358052
Seattle, WA  98109
Clinic: (206) 598-4615
Fax:  (206) 897-1546

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Education and Training

B.A. in Biology, Johns Hopkins University, Baltimore, MD, 1993.

M.D., Cornell University Medical College, New York, NY, 1998.

Internship and Residency (Internal Medicine), The Hospital of the University of Pennsylvania, Department of Medicine, Philadelphia, PA, 2001.

Fellowship, Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, 2004.

Research Fellow, Center for Lung Biology, University of Washington, Seattle, WA. 2006.

AC LS certified

Research Interests

My research focuses on understanding the mechanisms by which leukocyte recruitment to the lung is regulated. In particular, I am characterizing the role of epilysin (also known as matrix metalloproteinase 28) in regulating macrophage recruitment to the lung, and I have uncovered a novel role for this proteinase in restraining early macrophage recruitment and in modulating macrophage activation. Ongoing work in my laboratory focuses on using proteomics to determine novel epilysin substrates that are involved in regulating macrophage influx and activation. Additional areas of interest include the role of macrophage subpopulations on regulating lung epithelial cell responses to bacterial products and development of acute lung injury.

Representative Publications

Anne M. Manicone and John Mcquire. “Matrix Metalloproteinases as Modulators of Inflammation,” (2008) Seminars in Cell and Developmental Biology, 19, 34-41.

Anne M. Manicone, Kristi Burkhardt, Bao Lu, and Joan Clark, “CXCR3 Ligands Contribute to Th1-Induced Lung Inflammation but not to Homing of Th1 Cells into the Lung” Experimental Lung Research (2008) 34:7, 391-407.

Anne M. Manicone, “Inflammatory Signals and the Epithelial Cell in Acute Lung Injury,” Expert Review of Clinical Immunology (2009) 5:1, 63-75.

Anne M. Manicone, Timothy P. Birkland, Tomoko Betsuyaku, Nico Van Rooijen, Jouko Lohi, Jorma Keski-Oja, Ying Wang, Shawn J. Skerrett, and William C. Parks, “Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas Aeruginosa pneumonia” Journal of Immunology (2009) 182:6, 3866-76.

Anne M. Manicone, Isham Huizar, and John Mcguire, “Matrilysin (MMP-7) regulates anti-inflammatory and anti-fibrotic pulmonary dendritic cells that express CD103 (αEβ7-integrin),” American Journal of Pathology (2009) 175(6):2319-31.


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