Thomas R. Martin, MD

Thomas R. Martin, MD

Professor Emeritus
Division of Pulmonary and Critical Care Medicine
VA Puget Sound Health Care System

Education and Training

B.A. in Chemistry, Macalester College, St. Paul, MN, 1969.

M.D., University of Pennsylvania, Philadelphia, PA, 1973.

Internship in Straight Medicine, University of Washington,
Seattle, WA, 1974.

Residency in Straight Medicine, University of Washington,
Seattle, WA, 1976.

Fellowship in Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, 1980.

Research Sabbatical:

Visiting Scientist, Department of Immunology, Scripps Research Institute, La Jolla, CA, 1989-90.

Visiting Scientist, Department of Biochemistry, Geneva Biomedical Research Institute and Hospital of the University of Geneva, Geneva, Switzerland, 1997-98.

Research Interests

-- Investigation of the cellular and molecular mechanisms that regulate inflammatory responses and epithelial injury in the lungs.

-- Studies supported by the Seattle ALI Specialized Center of Clinical Research (SCCOR) in Acute Lung Injury investigate host factors that control innate immunity in normal and critically ill humans, and the interactions between innate immunity and lung injury due to mechanical ventilation.

-- Studies supported by the ALI SCCOR Program investigate the pathogenesis of lung epithelial injury in humans with ARDS, and in rabbit and murine models of pneumonia and sepsis.

-- Studies supported by a collaborative Program Project Grant with investigators at Scripps Research Institute investigate the cellular and molecular mechanisms by which bacterial products activate inflammatory responses in the lungs.

-- Studies supported by the VA Research Service investigate the mechanisms that regulate death of the alveolar epithelium in acute lung injury.

-- Studies suppoted by the UW Regional Center of Excellence in Biodefense investigate the role of bacterial cell wall structures from unusual pathogens in triggering innate immune responses in humans

Representative Publications

Wurfel MM, Park WY, Radella F, Ruzinski J, Sandstrom A, Strout J, Bumgarner RE, Martin TR. Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity. J. Immunol 2005;175:2570-2578.

Altemeier WA, Matute-Bello G, Gharib SA, Glenny RW, Martin TR, Liles WC. Modulation of LPS-induced gene transcription and promotion of lung injury by mechanical ventilation. J Immunol 2005;175:3369-3376.

Matute-Bello G, Liles WC, Frevert CW, Dhanireddy S, Ballman K, Wong V, Green RR, Song HY, Witcher DR, Jakubowski JA, Martin TR. Blockade of the Fas/FasL system improves pneumococcal clearance from the lung without preventing bacteremic dissemination to the spleen. J Infec Dis 2005;191:596-606.

Lee JS, Frevert CW, Matute-Bello G, Wurfel MM, Wong VA, Lin SM, Ruzinski J, Mongovin S, Goodman RB, Martin TR. TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia. Am J Physiol Lung Cell Mol Physiol 2005;289:L731-L738.

Matute-Bello G, Lee JS, Liles WC, Frevert CW, Mongovin S, Wong V, Ballman K, Sutlief S, Martin TR. Fas-mediated acute lung injury requires Fas expression on non-myeloid cells of the lung. J Immunol 2005;175:4069-4075.

Nakamura M, Matute-Bello G, Liles WC, Hayashi S, Kajikawa O, Lin SM, Frevert CW, Martin TR. Differential response of human lung epithelial cells to Fas-induced apoptosis. Am J Pathol 2004;164:1949-58.

 

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