gustavo matute-bello, MD

Associate Professor
Division of Pulmonary and Critical Care Medicine

Education and Training

MD, Central University of VenezuelaVargas Medical School Caracas, Venezuela.1988

Internship in Internal Medicine Albert Einstein Medical Center Philadelphia, PA 1992

Residency in Internal Medicine Albert Einstein Medical Center Philadelphia, PA 1994

Fellowship in Pulmonary and Critical Care Medicine University of Washington Seattle, WA 1998

ACLS Certification, 2012

Research Interests

My main interest is to understand the mechanisms leading to alveolar epithelial damage in acute lung injury, and the interactions of those mechanisms with lung host defenses. We have focused primarily on the role of apoptosis in the development of epithelial damage, with a particular emphasis on the Fas/FasL system. Our current hypothesis is that the Fas/FasL system plays multiple roles in the pathogenesis of acute lung injury, depending on the target cell: it contributes to destruction of the epithelium by promoting apoptosis of alveolar epithelial cells, it contributes to the fibrotic response by promoting fibroblast proliferation and collagen deposition, and it contributes to the inflammatory response by promoting cytokine release from alveolar macrophages. We are approaching this hypothesis by combining genomic and proteomic analyses, molecular biology techniques, cell biology, and experimental models of lung injury.

Representative Publications

Matute-Bello G, Liles WC, Steinberg KP, et al. Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury (ARDS). Journal of Immunology 1999;163:2217-2225

Matute-Bello G, Liles WC, Radella II F, et al. Modulation of neutrophil apoptosis by G-CSF and GM-CSF during the course of the acute respiratory distress syndrome (ARDS). Critical Care Medicine 2000;28:1-7

Matute-Bello G, Winn RK, Jonas M, Chi EY, Martin TR and Liles WC. Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. American Journal of Pathology 2001;158:153-161

Matute-Bello G, Liles WC, Frevert CW, et al. Recombinant human Fas-ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits. American Journal of Physiology 2001;281:L328--L335

Matute-Bello G, Frevert CW, Liles WC, et al. The Fas/FasL system mediates epithelial injury, but not pulmonary host defenses, in response to inhaled bacteria. Infection and immunity 2001;69:5768-5776

Martin TR, Nakamura M and Matute-Bello G. The role of apoptosis in acute lung injury. Crit Care Med 2003;31:S184-8

Matute-Bello G, Winn RK, Martin TR and Liles WC. Sustained LPS-induced lung inflammation in mice is attenuated by functional deficiency of the Fas/Fas ligand system. Clin Diag Lab Immunol 2004;11(2) 358-361.

 

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