gustavo matute-bello, MD
Division of Pulmonary and Critical Care Medicine
Center for Lung Biology
850 Republican Bldg.
Campus Box 358052
Seattle, WA 98109
Veterans Affairs Puget Sound Health Care System
1660 South Columbian Way
Seattle, WA 98108
Research Web Page
Academic Office: (206) 543-3166
Fax: (206) 685-8673
Clinic Appointments: (206) 598-4615
MD, Central University of VenezuelaVargas Medical School Caracas, Venezuela.1988
Internship in Internal Medicine Albert Einstein Medical Center Philadelphia, PA 1992
Residency in Internal Medicine Albert Einstein Medical Center Philadelphia, PA 1994
Fellowship in Pulmonary and Critical Care Medicine University of Washington Seattle, WA 1998
My main interest is to understand the mechanisms leading to alveolar epithelial damage in acute lung injury, and the interactions of those mechanisms with lung host defenses. We have focused primarily on the role of apoptosis in the development of epithelial damage, with a particular emphasis on the Fas/FasL system. Our current hypothesis is that the Fas/FasL system plays multiple roles in the pathogenesis of acute lung injury, depending on the target cell: it contributes to destruction of the epithelium by promoting apoptosis of alveolar epithelial cells, it contributes to the fibrotic response by promoting fibroblast proliferation and collagen deposition, and it contributes to the inflammatory response by promoting cytokine release from alveolar macrophages. We are approaching this hypothesis by combining genomic and proteomic analyses, molecular biology techniques, cell biology, and experimental models of lung injury.
Matute-Bello G, Liles WC, Steinberg KP, et al. Soluble Fas ligand induces epithelial cell apoptosis in humans with acute lung injury (ARDS). Journal of Immunology 1999;163:2217-2225
Matute-Bello G, Liles WC, Radella II F, et al. Modulation of neutrophil apoptosis by G-CSF and GM-CSF during the course of the acute respiratory distress syndrome (ARDS). Critical Care Medicine 2000;28:1-7
Matute-Bello G, Winn RK, Jonas M, Chi EY, Martin TR and Liles WC. Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. American Journal of Pathology 2001;158:153-161
Matute-Bello G, Liles WC, Frevert CW, et al. Recombinant human Fas-ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits. American Journal of Physiology 2001;281:L328--L335
Matute-Bello G, Frevert CW, Liles WC, et al. The Fas/FasL system mediates epithelial injury, but not pulmonary host defenses, in response to inhaled bacteria. Infection and immunity 2001;69:5768-5776
Martin TR, Nakamura M and Matute-Bello G. The role of apoptosis in acute lung injury. Crit Care Med 2003;31:S184-8
Matute-Bello G, Winn RK, Martin TR and Liles WC. Sustained LPS-induced lung inflammation in mice is attenuated by functional deficiency of the Fas/Fas ligand system. Clin Diag Lab Immunol 2004;11(2) 358-361.
van den Berg E, van Woensel JB, Bos AP, Bem RA, Altemeier WA, Gill SE, Martin TR, Matute-Bello G. Role of the Fas/FasL system in a model of RSV infection in mechanically ventilated mice. Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L451-60. 301(4):L451-60. PMCID: PMC3191752
Moon A, Gil S, Gill S, Chen P, Matute-Bello G. Doxycycline impairs neutrophil migration to the airspaces of the lung in mice exposed to intratracheal LPS. J Inflamm (Lond). 2012 Sep 3;9(1):31.
Gil S, Farnand AW, Altemeier WA, Gill SE, Kurdowska A, Krupa A, Florence JM, Matute-Bello G. Fas-deficient mice have impaired alveolar neutrophil recruitment and decreased expression of anti-KC autoantibody:KC complexes in a model of acute lung injury. Respiratory Research 2012, PMCID: PMC3499442.
Herrero R, Tanino M, Smith LS, Kajikawa O, Wong VA, Mongovin S, Matute-Bello G, Martin TR. The Fas/FasL pathway impairs the alveolar fluid clearance in mouse lungs. Am J Physiol Lung Cell Mol Physiol. 2013 Sep;305(5):L377-88. PMCID: PMC3763035
Altemeier WA, Liles WC, Villagra-Garcia A, Matute-Bello G, Glenny RW. Ischemia-Reperfusion Lung Injury Is Attenuated in MyD88-Deficient Mice. PLoS One. 2013 Oct 11;8(10):e77123. PMCID: PMC3795647