H. thomas robertson, ii, MD
Medicine and Physiology & Biophysics
Division of Pulmonary and Critical Care Medicine
University of Washington Medical Center
1959 N.E. Pacific, Campus Box 356522
Seattle, WA 98195-6522
Research Web Page
Academic Office: (206) 543-3166
Fax: (206) 685-8673
Clinic Appointments: (206) 598-4615
Education and Training
B.A. in Chemistry, Colgate University, Hamilton, New York, 1964.
M.D. in Medicine, Harvard Medical School, Boston, Massachussetts, 1968.
My primary research emphasis has been gas exchange in the normal and abnormal lung. Utilizing the inhalation of fluorescent aerosols and the injection of fluorescent microspheres, we take high-resolution measurements of ventilation and blood flow to obtain complete flow maps of the lung.
The correlation between these two flows determines the efficiency of overall pulmonary gas exchange. One research question under investigation is the importance of scale in determining gas exchange efficiency, as both regional ventilation and ventilation have fractal properties. A second focus is the study of mechanisms which determine this matching of flows. A clinical research interest centers around the mechanisms determining exercise limitation in a wide variety of human disease conditions, utilizing the clinical exercise studies performed in the pulmonary diagnostic laboratory.
Hopkins SR, McKenzie DC, Schoene RB, Glenny RW, Robertson HT. Pulmonary gas exchange during exercise in athletes: I. Ventilation-perfusion mismatch and diffusion limitation. J App Physiol 77:912-917, 1994.
Glenny RW, Polissar NL, McKinney S, and Robertson HT. Temporal heterogeneity of regional pulmonary perfusion is spatially clustered. J Appl Physiol 79:986-1001, 1995.
Robertson HT, Glenny RW, Stanford D, McInnes LM, Luchtel DL, Covert D. High-resolution maps of regional ventilation utilizing inhaled fluorescent microspheres. J App Physiol 82:943-953, 1997.
Altemeier WA,Robertson HT,McKinney S, Glenny RW. Pulmonary embolizationcauses hypoxemia by redistributing regional blood flow without changingventilation. J Appl Physiol. 85:2337-43, 1998.
Altemeier WA, Robertson HT, Glenny RW. Pulmonary gas-exchange analysis by using simultaneous deposition of aerosolized and injected microspheres. J Appl Physiol. Dec;85(6):2344-51, 1998.