shawn j. skerrett, MD
Division of Pulmonary and Critical Care Medicine
Harborview Medical Center
325 Ninth Avenue, Box 359762
Seattle, WA 98104
Education and Training
B.A. in Human Biology, Stanford University, Stanford, CA, 1974.
M.D. in Medicine, New York University, New York, NY, 1978.
Internship in Medicine, Yale-New Haven Hospital, New Haven, CT, 1978.
Residency in Medicine, Yale-New Haven Hospital, New Haven, CT, 1979.
Fellowship in Infectious Diseases, University of Washington, 1983.
Fellowship in Pulmonary and Critical Care Medicine, University of Washington,
The overall objective is a better understanding of the cellular and molecular basis of pulmonary host defenses against infection.
One project addreses the interactions of Legionella pneumophila and mycobacterium tuberculosis with human alveolar macrophages, to define critical mechanisms of resistance against intracellular infection, and determine how virulent pathogens subvert host defenses.
An additional project studies the integration of cell-mediated immune responses in vivo, using a model of legionellosis in strains of transgenic mice with specific molecular defects in local and systemic defenses.
Other active projects include studies of the regulation of chemokine expression in human respiratory epithelial cells, studies of cytokine regulation of lung inflammation, and studies of the molecular pathogenesis of acute lung injury in a rabbit model.
Skerrett SJ, Martin TR, Chi EY, Peschon JJ, Mohler KM, Wilson CB: Role of the type 1 TNF receptor in lung inflammation after inhalation of endotoxin or Pseudomonas aeruginosa. Am J Physiol 276 (Lung Cell Mol Physiol 20):L715-L727, 1999.
Smith S, Skerrett SJ, Chi EY, Mohler K, Peschon J, Wilson CB: The locus of tumor necrosis factor-alpha action in lung inflammation. Am J Respir Cell Mol Biol 19:881-891, 1998.
Skerrett SJ, Bagby GJ, Schmidt RA, Nelson S: Antibody-mediated depletion of tumor necrosis factor-alpha impairs pulmonary host defenses to Legionella pneumophila. J Infect Dis 176:1019-1028, 1997.
Park PR, Skerrett SJ: IL-10 enhances the growth of Legionella pneumphila in human mononuclear phagocytes and reverses the protective effect of IFN-alpha. Differential responses of blood monocytes and alveolar macrophages. J Immunol 157:2528-2538, 1996.
Skerrett SJ, Martin TR: Role for tumor necrosis factor-alpha and nitric oxide in the resistance of rat alveolar macrophages to Legionella pneumophila. Infect Immunol 64:3236-3243, 1996.