EDUCATION
AND TRAINING
B.Sc. (Medical Science), Edinburgh University
Medical School, Edinburgh, Scotland, 1975.
M.B.Ch.B., merit certificates awarded in
Chemistry, Forensic Medicine, Edinburgh
University Medical School, Edinburgh, Scotland,
1978.
M.D., Edinburgh University Medical School,
Edinburgh, Scotland, 1992.
Internship in Internal Medicine, Western General
Hospital, and Royal Infirmary Hospital,
Edinburgh, Scotland, 1979.
Residency in Internal Medicine, Western General
Hospital, Northern General Hospital and Royal
Infirmary Hospital, Edinburgh, Scotland, 1982.
Fellowship in Pulmonary Medicine, University of
Washington, Seattle, WA, 1985.
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CURRENT
RESEARCH INTERESTS
Overall objectives are to understand the
mechanisms of airway inflammation and infection
in cystic fibrosis (CF). The CF gene product,
CFTR, leads to airway inflammation though a
series of abnormalities, including hypertonicity
of periciliary fluid encouraging bacterial
growth, altering airway adhesion molecules, and
altering a variety of intracellular protein
trafficking. She is also involved in Phase I and
II clinical trials and in epidemiological studies
of CF.
REPRESENTATIVE
PUBLICATIONS
McKone EF, Emerson SS, Edwards KL, Aitken
ML. Effect of genotype on phenotype and mortality
in cystic fibrosis: a retrospective cohort study.
Lancet. 2003 May 17;361(9370):1671-6.
Aitken ML, Greene KE, Tonelli MR, Burns JL,
Emerson JC, Goss CH. Analysis of sequential
aliquots of hypertonic saline solution-induced
sputum from clinically stable patients with
cystic fibrosis. Chest. 2003
Mar;123(3):792-9.
Ordonez CL, Henig NR, Mayer-Hamblett N, Accurso
FJ, Burns JL, Chmiel JF, Daines CL, Gibson RL,
McNamara S, Retsch-Bogart GZ, Zeitlin PL, Aitken
ML. Inflammatory and microbiologic markers in
induced sputum after intravenous antibiotics in
cystic fibrosis. Am J Respir Crit Care Med.
2003 Dec 15;168(12):1471-5.
Goss CH, Rubenfeld GD, Otto K, Aitken ML. The
effect of pregnancy on survival in women with
cystic fibrosis. Chest. 2003
Oct;124(4):1460-8.
Mayer-Hamblett N, Rosenfeld M, Emerson J, Goss
CH, Aitken ML. Developing cystic fibrosis lung
transplant referral criteria using predictors of
2-year mortality. Am J Respir Crit Care Med. 2002 Dec 15;166(12 Pt 1):1550-5.
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