EDUCATION
AND TRAINING
BS, Electrical Engineering, The University of Texas at Austin, 1994.
MD, Baylor College of Medicine, Houston, TX 1999.
Internship, Internal Medicine, University of Texas at Southwestern Medical Center, Dallas, TX 2000.
Residency, Internal Medicine, University of Texas at Southwestern Medical Center, Dallas, TX 2002.
Fellowship, Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 2005.
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CURRENT RESEARCH
INTERESTS
My research focuses on defining the mechanisms that govern airway re-epithelialization and how inappropriate repair results in airway fibrosis (e.g., obliterative bronchiolitis). In particular, we have been studying how matrilysin (matrix metalloproteinase-7) facilitates re-epithelialization in the injured lungs. Utilized in vitro and in vivo models of airway epithelial injury, we have identified syndecan-1 as a putative substrate, which upon cleavage by matrilysin, relaxes cell-matrix adhesion allowing the injured epithelium to migrate over the wound. Matrilysin cleavage of syndecan-1 has also previously been identified to also play an important role in regulating lung inflammation after injury. Therefore, our findings may represent a method by which nature has co-opted two inter-related phenomena, namely repair and inflammation, into one biological process.
REPRESENTATIVE PUBLICATIONS
Kim KH, Burkhart K, Chen P, Frevert CW, Randolph-Habacker J, Hackman RC, Soloway PD, Madtes DK. Tissue Inhibitor of Metalloproteinase-1 Amplifies Acute Lung Injury in Bleomycin Exposed Mice. Amer J. Resp. Cell Mol. Biol 2005 ; 33(3) :271-279.
Chen P, Farivar AS, Mulligan MS, Madtes DK. TIMP-1 Deficiency Abrogates Obliterative Airway Disease after Heterotopic Tracheal Transplantation. Amer J. Resp. Cell Mol. Biol 2006 ; 34(4) :464-472.
Farivar AS, Yunusov MY, Chen P, Leone RJ, Madtes DK, Kuhr, CS, Spector MR, Abrams K, Hwang B, Nash RA, Mulligan MS. Optimizing a canine survival model of orthotopic lung transplantation. Transplant P. 2006 Jun;38(5):1638-40.
Chen P, McGuire JK, Hackman RC, Kim KH, Black RA, Poindexter K, Yan W, Liu P, Chen AJ, Parks WC, Madtes DK. Tissue Inhibitor of Metalloproteinase-1 Moderates Airway Re-epithelialization by Regulating Matrilysin Activity. Am J Pathol. 2008; 172:1256-70.
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