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Jason
W. Chien, M.D., M.S.
Assistant Professor of Medicine
Pulmonary and Critical Care Medicine
OFFICE ADDRESS
Pulmonary and Critical Care Section
Clinical Research Division
Fred Hutchinson Cancer Research Center
1100 Fairview Ave North, Suite D5-280
P.O. Box 19024
Seeattle, WA 98109-1024
jchien@fhcrc.org
Academic Office: (206) 667-4860
Fax: (206) 667-5899
For additional profile
information, click here.
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EDUCATION
AND TRAINING
B.A., University of Michigan, Ann Arbor, MI,
1989.
M.D., University of Medicine and Dentistry, New
Jersey Medical School, Newark, NJ, 1994.
Internship in Internal Medicine, Case Western
Reserve University, Cleveland, OH, 1995.
Residency in Internal Medicine, Case Western
Reserve University, Cleveland, OH, 1997.
Fellowship in Infectious Diseases, Case Western
Reserve University, Cleveland, OH, 1999.
Fellowship in Pulmonary and Critical Care
Medicine, University of Washington, Seattle, WA,
2002.
Masters of Science in Genetic Epidemiology,
University of Washington, Seattle, WA, 2005.
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CURRENT RESEARCH
INTERESTS
Genetic epidemiology of the innate immune
response and its relationship to clinical
phenotypes, such as infections and airway
diseases. In particular, the pursuit of
complex clinical phenotypes that occur after
hematopoietic stem cell transplantation, such as
graft versus host disease, Gram-negative and
Gram-positive bacteremia, invasive fungal
infection, viral infections, idiopathic pneumonia
syndrome, overall lung function decline, and
bronchiolitis obliterans. The results of
these studies will ultimately be translated to
studies of more common clinical phenotypes such
as sepsis, acute lung injury, and chronic airway
diseases.
REPRESENTATIVE PUBLICATIONS
Chien, JW, Martin PJ, Gooley TA, Flower ME,
Heckbert SR, Nichols WG, Clark JG. Airflow
obstruction after myeloablative allogeneic
hematopoietic stem cell transplantation. Am J
Respir Crit Care Med. 2003;168:208-214.
Chien JW, Martin PJ, Flowers ME, Nichols WG,
Clark JG. Implications of early airflow decline
after myeloablative allogeneic hematopoietic stem
cell transplantation. Bone Marrow Transplant.
2004;33:759-764.
Chien JW, Maris MB, Sandmaier BM, Maloney G,
Storb RF, Clark JG. Comparison of lung function
after myeloablative and 2Gy TBI based regimens
for hematopoietic stem cell transplantation. Biol
Blood Marrow Transplant 2005; 11:288-296.
Parimon T, Madtes DK, Au DH, Clark JG, Chien JW.
Pretransplant lung function, respiratory failure,
and mortality after stem cell transplantation. Am
J Respir Crit Care Med 2005; 172:384-390.
Chien JW, Zhao LP, Hansen JA, Fan WH, Li S, Clark
JG. Genetic variation in
bactericidal/permeability increasing protein
influences the risk for developing rapid airflow
decline after hematopoietic cell transplantation.
Blood 2006; 107(5) 2200-2207.
Parimon T, Au DH, Martin PJ, Chien JW. A Risk
Score for Mortality after Allogeneic
Hematopoietic Cell Transplantation. Ann Int
Med 2006; 144(6) 407-14.
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Last reviewed: February 7, 2006 - Last updated: February
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