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Joan
G. Clark, M.D.
Professor of Medicine, Section Head
Pulmonary and Critical Care Medicine
OFFICE ADDRESS
Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N. (D3-190)
P.O. Box 19024
Seattle, WA 98109-1024
jclark@fhcrc.org
Academic Office: (206) 667-5073
Fax: (206) 667-5765
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EDUCATION
AND TRAINING
B.A., University of Minnesota, Minneapolis, MN,
1970.
M.D., Washington University, St. Louis, MO, 1974.
Internship in Internal Medicine, Washington
University, St. Louis, MO, 1975.
Residency in Internal Medicine, Washington
University, St. Louis, MO, 1977.
Fellowship in Pulmonary Diseases, Washington
University, St. Louis, MO, 1979.
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CURRENT RESEARCH
INTERESTS
Investigations of acute lung injury association
with systemic immune responses involving both
cellular and cytokine components.
The central hypothesis is that Th 1 cell
activation initiates a multi-step sequence of
signals that results in selective adherence of
activated effector T cells in lung, amplification
by selective recruitment of mononuclear cells,
and accumulation of activated mononuclear cells
and alveolar macrophages.
REPRESENTATIVE PUBLICATIONS
Clark JG, Hansen JA, Hertz MI, Parkman R, Jensen
L, Peavy HH. Idiopathic pneumonia syndrome
following bone marrow transplantation. Am Rev
Respir Dis 147:1601-1606, 1993.
Strandjord TP, Sage EH, Clark JG. SPARC
participates in the branching morphogenesis of
developing fetal lung. Am J Respir Cell Mol
Biol 13:279-287, 1995.
Chesnutt AN, Matthay MA, Tibaya F, Clark JG.
Early detection of type III procollagen peptide
in acute lung injury: Pathogenetic and prognostic
significance. Am J Respir Crit Care Med
156:840-847, 1997.
Weiss DJ, Liggit D, Clark JG. In situ
histochemical detection of beta-galactosidase
activity in lung: assessment of X-gal reagent in
distinguishing Lac-Z gene expression and
endogenous beta-galactosidase activity. Hum
Gene Ther 8:1545-1554, 1997.
Clark JG, Hackman RC, Madtes DK, Chen W, Cheever
MA, Martin PJ. Lung injury induced by
alloreactive Th1 cells is characterized by host
derived mononuclear cell inflammation and
activation of alveolar macrophages. J Immunol
161:1913-1920, 1998.
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Last reviewed: October 27, 2004 - Last updated: Octobe
27, 2004
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