EDUCATION
AND TRAINING
B.A. in Chemistry, St. Olaf College, Northfield,
MN, 1976.
M.A. in Biochemistry, University of South Dakota,
Vermillion, SD, 1980.
M.D., University of Oklahoma, Oklahoma City, OK,
1982.
Internship, Residency and Chief Residency in
Internal Medicine, University of Oklahoma Health
Science Center, Oklahoma City, OK, 1982-1986.
Clinical Fellowship in Pulmonary and Critical
Care Medicine, University of Washington, Seattle,
WA, 1986-1987.
Research Fellowship in Pulmonary and Crtiical
Care Medicine (Laboratory of Thomas R. Martin,
M.D.), University of Washington, Seattle, WA,
1987-1989.
Visiting Scientist (protein chemistry);
ZymoGenetics, Corp., (Laboratory of John W.
Forstrom, Ph.D.) Seattle, WA, 1989-1990.
Visiting Scientist (molecular biology);
ZymoGenetics, Corp., (Laboratory of Donald C.
Foster, Ph.D.) Seattle, WA. 1991-1993. |
CURRENT RESEARCH
INTERESTS
The primary focus of this laboratory is the study
of molecular mechanisms of lung inflammation. We
are interested in defining the relative
contribution made by neutrophils (PMN) to the
pathological process of acute lung injury. Our
goals are to identify the predominant signals
produced by lung cells which recruit PMN from the
blood stream (known as chemoattractants or
chemokines), to define the dominant cell surface
receptor(s) responsible for PMN migration, and to
investigate strategies to block PMN migration in
pre-clinical disease models of acute lung injury.
REPRESENTATIVE
PUBLICATIONS
Cummings J, Martin TR, Frevert CW, Quan JM, Wong
VA, Mongovin SM, Hagen TR, and Goodman RB.
Expression and function of the chemokine
receptors CXCR1 and CXCR2 in sepsis. J
Immunol, 162:2341-2346, 1999.
Goodman RB, Strieter RM, Frevert CW, Cummings JC,
Tekamp-Olson P, Kunkel SL, Walz A, Martin TR.
Quantitative comparison of CXC-chemokines
produced by endotoxin-stimulated human alveolar
macrophages. Am J Physiol: Lung Cell Molec
Physiol (Submitted).
Frevert C, Wong VA, Goodman RB, Goodwin R, Martin
TR. Rapid fluorescence-based measurement of
neutrophil migration in vitro. J Immunol
Methods 213:41-52, 1998.
Goodman RB, Strieter RM, Martin DP, Steinberg KP,
Milberg JA, Maunder RJ, Kunkel SL, Walz A, Hudson
LD, Martin TR. Inflammatory Cytokines in Patients
with Persistence of the Acute Respiratory
Distress Syndrome. Am J Respir Crit Care Med
154:602-611, 1996.
Quan JM, Martin TR, Rosenberg BG, Foster DC,
Whitmore T, and Goodman RB. Antibodies Against
the N-terminus of IL-8 Receptor A Inhibit
Neutrophil Chemotaxis. Biochem Biophys Res
Commun 219: 405-411, 1996.
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