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David
K. Madtes, M.D.
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
OFFICE ADDRESS
Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N. (D3-190)
P.O. Box 19024
Seattle, WA 98109-1024
dmadtes@fhcrc.org
Academic Office: (206) 667-5120
Fax: (206) 667-5765
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EDUCATION
AND TRAINING
B.A. in Chemistry, Gettysburg College,
Gettysburg, PA, 1974.
M.D. in Medicine, University of Pittsburgh,
Pittsburgh, PA, 1979.
Internship at the University of Rochester, Strong
Memorial Hospital, Rochester, NY, 1980.
Residency at the University of Rochester, Strong
Memorial Hospital, Rochester, NY, 1982.
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CURRENT RESEARCH
INTERESTS
The focus of research is on the cellular and
molecular mechanisms responsible for normal
alveolar development and repair and for the
fibroproliferative response that results in
pulmonary fibrosis. Two primary projects: are 1)
the identification of growth factors that
regulate the cellular proliferation and
extracellular matrix remodeling in the injured
alveolus and in the developing lung; and 2) the
identification of matrix metalloproteinases and
tissue inhibitors of metalloproteinases
responsible for extracellular remodeling in lung
fibrosis.
REPRESENTATIVE PUBLICATIONS
Madtes DK, Raines EW, Sakariassen KS, Assoian RK,
Sporn MB, Bell GI, and Ross R. Induction of
transforming growth factor-alpha in activated
human alveolar macrophages. Cell 53:285-293,
1988.
Strandjord TP, Clark JG, Hodson WA, Schmidt RA,
Madtes DK. Expression of transforming growth
factor-alpha in mid-gestation human fetal lung.
Am J Respir Cell Mol Biol 8:266-272, 1993.
Madtes DK, Busby HK, Strandjord TP, Clark JG.
Expression of transforming growth factor-alpha
and epidermal growth factor receptor is increased
following bleomycin induced lung injury in rats. Am
J Respir Cell Mol Biol 11:540-551, 1994.
Madtes DK, Rubenfeld G, Klima LD, Milberg JA,
Steinberg KP, Martin TM, Raghu G, Hudson LD,
Clark JC. Elevated transforming growth
factor-alpha levels in bronchoalveolar lavage
fluid of patients with acute respiratory distress
syndrome. Am J Resp Crit Care Med
158:424-430, 1998.
Madtes DK, Elston AL, Hackman RC, Dunn AR, Clark
JG. Transforming growth factor-alpha deficiency
reduces pulmonary fibrosis in transgenic mice. Am
J Respir Cell Mol Biol 20:924-934, 1999.
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Last reviewed: October 28, 2004 - Last updated: October 28, 2004
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