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Thomas
R. Martin, M.D.
Professor of Medicine
Pulmonary and Critical Care Medicine
Vice Chair
Department of Medicine
Chief, Medical Service
Veterans Affairs Puget Sound Health Care System
OFFICE ADDRESS
Pulmonary Research Laboratory
Veterans Affairs Puget Sound Health Care System
1660 South Columbian Way
UW Box 358280-151L
Seattle, WA 98108
trmartin@u.washington.edu
Academic Office: (206) 764-2219
(c/o Deborah Snapp, Program Manager)
Fax: (206) 768-5289
Clinic Appointments: (206) 764-2504 or
1-800-329-8387 (return patients)
(206) 764-2306 (new patients)
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EDUCATION AND TRAINING
B.A. in Chemistry, Macalester College, St. Paul,
MN, 1969.
M.D., University of Pennsylvania, Philadelphia,
PA, 1973.
Internship in Straight Medicine, University of
Washington,
Seattle, WA, 1974.
Residency in Straight Medicine, University of
Washington,
Seattle, WA, 1976.
Fellowship in Pulmonary and Critical Care
Medicine, University of Washington, Seattle, WA,
1980.
Research Sabbatical:
Visiting Scientist, Department of Immunology,
Scripps Research Institute, La Jolla, CA,
1989-90.
Visiting Scientist, Department of Biochemistry,
Geneva Biomedical Research Institute and Hospital
of the University of Geneva, Geneva, Switzerland,
1997-98.
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| CURRENT RESEARCH
INTERESTS |
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-- Investigation of
the cellular and molecular mechanisms
that regulate inflammatory responses and
epithelial injury in the lungs.
-- Studies supported by the Seattle ALI
Specialized Center of Clinical Research
(SCCOR) in Acute Lung Injury investigate
host factors that control innate immunity
in normal and critically ill humans, and
the interactions between innate immunity
and lung injury due to mechanical
ventilation.
-- Studies supported by the ALI
SCCOR Program investigate the
pathogenesis of lung epithelial injury in
humans with ARDS, and in rabbit and
murine models of pneumonia and sepsis.
-- Studies supported by
a collaborative Program Project Grant
with investigators at Scripps Research
Institute investigate the cellular and
molecular mechanisms by which bacterial
products activate inflammatory responses
in the lungs.
-- Studies supported by
the VA Research Service investigate the
mechanisms that regulate death of the
alveolar epithelium in acute lung injury.
-- Studies suppoted by
the UW Regional Center of Excellence in
Biodefense investigate the role of
bacterial cell wall structures from
unusual pathogens in triggering innate
immune responses in humans |
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REPRESENTATIVE
PUBLICATIONS
Wurfel MM, Park WY, Radella F, Ruzinski J,
Sandstrom A, Strout J, Bumgarner RE, Martin TR.
Identification of high and low responders to
lipopolysaccharide in normal subjects: an
unbiased approach to identify modulators of
innate immunity. J. Immunol 2005;175:2570-2578.
Altemeier WA, Matute-Bello G, Gharib SA, Glenny
RW, Martin TR, Liles WC. Modulation of
LPS-induced gene transcription and promotion of
lung injury by mechanical ventilation. J
Immunol 2005;175:3369-3376.
Matute-Bello G, Liles WC, Frevert CW, Dhanireddy
S, Ballman K, Wong V, Green RR, Song HY, Witcher
DR, Jakubowski JA, Martin TR. Blockade of the
Fas/FasL system improves pneumococcal clearance
from the lung without preventing bacteremic
dissemination to the spleen. J Infec Dis
2005;191:596-606.
Lee JS, Frevert CW, Matute-Bello G, Wurfel MM,
Wong VA, Lin SM, Ruzinski J, Mongovin S, Goodman
RB, Martin TR. TLR-4 pathway mediates the
inflammatory response but not bacterial
elimination in E. coli pneumonia. Am J
Physiol Lung Cell Mol Physiol 2005;289:L731-L738.
Matute-Bello G, Lee JS, Liles WC, Frevert CW,
Mongovin S, Wong V, Ballman K, Sutlief S, Martin
TR. Fas-mediated acute lung injury requires Fas
expression on non-myeloid cells of the lung. J
Immunol 2005;175:4069-4075.
Nakamura M, Matute-Bello G, Liles WC, Hayashi S,
Kajikawa O, Lin SM, Frevert CW, Martin TR.
Differential response of human lung epithelial
cells to Fas-induced apoptosis. Am J Pathol
2004;164:1949-58.
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Comments to Donna Schier, dschier@u.washington.edu
Last Reviewed: January 20, 2006- Last Updated: January
20, 2006
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