EDUCATION
AND TRAINING
MD, Central University of VenezuelaVargas Medical
School Caracas, Venezuela.1988
Internship in Internal Medicine Albert Einstein
Medical Center Philadelphia, PA 1992
Residency in Internal Medicine Albert Einstein
Medical Center Philadelphia, PA 1994
Fellowship in Pulmonary and Critical Care
Medicine University of Washington Seattle, WA
1998
|
CURRENT RESEARCH
INTERESTS
My main interest is to understand the mechanisms
leading to alveolar epithelial damage in acute
lung injury, and the interactions of those
mechanisms with lung host defenses. We have
focused primarily on the role of apoptosis in the
development of epithelial damage, with a
particular emphasis on the Fas/FasL system. Our
current hypothesis is that the Fas/FasL system
plays multiple roles in the pathogenesis of acute
lung injury, depending on the target cell: it
contributes to destruction of the epithelium by
promoting apoptosis of alveolar epithelial cells,
it contributes to the fibrotic response by
promoting fibroblast proliferation and collagen
deposition, and it contributes to the
inflammatory response by promoting cytokine
release from alveolar macrophages. We are
approaching this hypothesis by combining genomic
and proteomic analyses, molecular biology
techniques, cell biology, and experimental models
of lung injury.
REPRESENTATIVE PUBLICATIONS
Matute-Bello G, Liles WC, Steinberg KP, et al.
Soluble Fas ligand induces epithelial cell
apoptosis in humans with acute lung injury
(ARDS). Journal of Immunology 1999;163:2217-2225
Matute-Bello G, Liles WC, Radella II F, et al.
Modulation of neutrophil apoptosis by G-CSF and
GM-CSF during the course of the acute respiratory
distress syndrome (ARDS). Critical Care Medicine
2000;28:1-7
Matute-Bello G, Winn RK, Jonas M, Chi EY, Martin
TR and Liles WC. Fas (CD95) induces alveolar
epithelial cell apoptosis in vivo: implications
for acute pulmonary inflammation. American
Journal of Pathology 2001;158:153-161
Matute-Bello G, Liles WC, Frevert CW, et al.
Recombinant human Fas-ligand induces alveolar
epithelial cell apoptosis and lung injury in
rabbits. American Journal of Physiology
2001;281:L328--L335
Matute-Bello G, Frevert CW, Liles WC, et al. The
Fas/FasL system mediates epithelial injury, but
not pulmonary host defenses, in response to
inhaled bacteria. Infection and immunity
2001;69:5768-5776
Martin TR, Nakamura M and Matute-Bello G. The
role of apoptosis in acute lung injury. Crit Care
Med 2003;31:S184-8
Matute-Bello G, Winn RK, Martin TR and Liles WC.
Sustained LPS-induced lung inflammation in mice
is attenuated by functional deficiency of the
Fas/Fas ligand system. Clin Diag Lab Immunol
2004;11(2) 358-361.
|
