EDUCATION
AND TRAINING
B.A. in Human Biology, Stanford University,
Stanford, CA, 1974.
M.D. in Medicine, New York University, New York,
NY, 1978.
Internship in Medicine, Yale-New Haven Hospital,
New Haven, CT, 1978.
Residency in Medicine, Yale-New Haven Hospital,
New Haven, CT, 1979.
Fellowship in Infectious Diseases, University of
Washington, 1983.
Fellowship in Pulmonary and Critical Care
Medicine, University of Washington,
Seattle, WA, 1985
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CURRENT RESEARCH
INTERESTS
The overall objective is a better understanding
of the cellular and molecular basis of pulmonary
host defenses against infection.
One project addreses the interactions of
Legionella pneumophila and mycobacterium
tuberculosis with human alveolar macrophages, to
define critical mechanisms of resistance against
intracellular infection, and determine how
virulent pathogens subvert host defenses.
An additional project studies the integration of
cell-mediated immune responses in vivo,
using a model of legionellosis in strains of
transgenic mice with specific molecular defects
in local and systemic defenses.
Other active projects include studies of the
regulation of chemokine expression in human
respiratory epithelial cells, studies of cytokine
regulation of lung inflammation, and studies of
the molecular pathogenesis of acute lung injury
in a rabbit model.
REPRESENTATIVE PUBLICATIONS
Skerrett SJ, Martin TR, Chi EY, Peschon JJ,
Mohler KM, Wilson CB: Role of the type 1 TNF
receptor in lung inflammation after inhalation of
endotoxin or Pseudomonas aeruginosa. Am J
Physiol 276 (Lung Cell Mol Physiol
20):L715-L727, 1999.
Smith S, Skerrett SJ, Chi EY, Mohler K, Peschon
J, Wilson CB: The locus of tumor necrosis
factor-alpha action in lung inflammation. Am
J Respir Cell Mol Biol 19:881-891, 1998.
Skerrett SJ, Bagby GJ, Schmidt RA, Nelson S:
Antibody-mediated depletion of tumor necrosis
factor-alpha impairs pulmonary host defenses to
Legionella pneumophila. J Infect Dis
176:1019-1028, 1997.
Park PR, Skerrett SJ: IL-10 enhances the growth
of Legionella pneumphila in human mononuclear
phagocytes and reverses the protective effect of
IFN-alpha. Differential responses of blood
monocytes and alveolar macrophages. J Immunol
157:2528-2538, 1996.
Skerrett SJ, Martin TR: Role for tumor necrosis
factor-alpha and nitric oxide in the resistance
of rat alveolar macrophages to Legionella
pneumophila. Infect Immunol
64:3236-3243, 1996.
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