research
Christopher H. Goss
Associate Professor
Division of Pulmonary and Critical Care Medicine
Adjunct Associate Professor of Pediatrics
MD, MSc
Faculty Web Page
Last updated: January 11, 2011
Research Focus
My research focus has been in clinical outcomes, clinical epidemiology and clinical trials in cystic fibrosis. I am currently the Chief Medical Officer of the Cystic Fibrosis Therapeutics Development Network Coordinating Center in Seattle, Washington. I have formal training clinical epidemiology, biostatistics, and clinical trial design. I have conducted a number of observational epidemiology studies in cystic fibrosis, identifying risk factors that modify outcome in cystic fibrosis. I have also involved in enhancing clinical safety during clinical trials by analyzing existing data bases to describe the natural history of cystic fibrosis patients receiving placebo. More recently, I have also focused on improving our understanding of health related quality of life instruments and developing a novel symptom questionnaire and diary for cystic fibrosis. We are currently deploying our symptom questionnaire along with home spirometry in a multi-center randomized controlled trial assessing the efficacy of home monitoring on clinical outcomes in cystic fibrosis. My group also has been doing translational work related to the development of novel antimicrobial agents for the treatment of cystic fibrosis and understanding the underlying mechanisms of acute pulmonary exacerbation in conjunction with Dr. Pradeep Singh’s laboratory.
Relevant Publications
Goss, CH, Aitken, ML, Otto, K, Rubenfeld, GD. Detecting Stenotrophomonas maltophilia does not decrease survival in patients with cystic fibrosis. Am J Respir Crit Care Med. 2002 Aug 1;166(3):356-61.
Goss, CH, Newsom, SA, Schildcrout, JS, Sheppard, L, Kaufman, JD. The effect of ambient air pollution on pulmonary health in the cystic fibrosis population. Am J Respir Crit Care Med 2004 Apr 1;169(7):816-21.
Goss, CH, Mayer-Hamblett, N, Rubenfeld, GD, Aitken, ML and Ramsey, BW. S. maltophilia and lung function. Thorax 2004; 59: 955-959.
Goss, CH, Rubenfeld, GD, Ramsey, BW, Aitken, ML. Clinical trial participants compared to non-participants in cystic fibrosis. Am J Respir Crit Care Med. 2006 Jan 1;173(1):98-104.
Kahn, JM, Goss, CH, Heagerty, PJ, Kramer, AA, Rubenfeld, GD. Hospital volume and the outcomes of mechanical ventilation. N Engl J Med 2006;355:41-50.
Gries, CJ, Mulligan, MS, Edelman, J, Raghu, G, Curtis, JR, Goss, CH. Lung Allocation Score for Lung transplantation: Impact on disease severity and Survival. Chest Dec 2007: 1954–1961.
Ortiz, JR, Neuzil, KM, Victor, JC, Aitken, ML, Goss, CH. Influenza-associated cystic fibrosis pulmonary exacerbations. Chest. 2010; 137 (4):852-60.
Gries CJ, Rue TC, Heagerty PJ, Edelman JD, Goss CH. Development of a Predictive Model for Long-Term Survival after Lung Transplantation and Implications for the Lung Allocation Score. J Heart Lung Transplant. 2010 Jul;29(7):731-8.
Sanders, DB, Bittner, RCL, Rosenfeld, M, Hoffman, LR, Redding, GJ, and Goss CH. Failure to Recover to Baseline Pulmonary Function after Cystic Fibrosis Pulmonary Exacerbation. Am J Respir Crit Care Med. 2010 Sep 1;182(5):627-32.
Active Funding
Funding Source |
Project Title |
Investigator Role |
Funding Dates |
NIH/NHLBI |
Early Intervention in Acute Pulmonary Exacerbation in CF |
PI |
9/2010-8/2015 |
FDA |
A pharmacokinetic and safety study of IV gallium nitrate (Ganite) in cystic fibrosis patients |
PI |
9/2009-8/2011 |
Cystic Fibrosis |
A pharmacokinetic and safety study of IV gallium nitrate (Ganite) in cystic fibrosis patients |
PI |
7/2009-6/2011 |
NIH/NIDDK |
Translational Research Center for Expedite Novel Therapies in Cystic Fibrosis |
Clinical Translational Core Director |
7/2010-6/2015 |
Cystic Fibrosis |
STAR-TOO: An Evaluation of the Efficacy and Safety of Early Treatment of New Onset MRSA |
PI |
11/2010-10/2013 |
NIH/NCRR |
Advancing Reported Outcomes in Children with CF |
PI |
9/2009-5/2011 |
Cystic Fibrosis |
Early Intervention in Pulmonary Exacerbation in CF |
PI |
7/2008-6/2011 |
Cystic Fibrosis |
TLR-mediated innate immune responses and pulmonary phenotype |
Co-Investigator |
7/2008-6/2011 |
Current Mentees
Name |
Degree |
Current Title |
Project |
| Donald B Sanders |
MD MS | Assistant Prof. Univ of Wisconsin |
Elucidating predictors of recovery after an acute pulmonary exacerbation in cystic fibrosis & chest CT as a predictor of later pulmonary complications in cystic fibrosis children |
| Bradley S Quon | MD | Research Fellow UW |
Describing the prevalence,
incidence and predictors of renal failure in cystic fibrosis |
| Justin R Ortiz | MD | Acting Instructor UW |
Assessing the role of respiratory
viruses in acute pulmonary exacerbation in cystic fibrosis & the role of influenza season on critical illness |
| Christopher W Seymour |
MD MS | Acting Instructor UW |
Studying severe sepsis and septic shock in the pre-hospital setting |
| David J Horne | MD MPH | Acting Instructor UW |
Determining the clinical and exposure- related risk factors for TB infection in a prospective cohort of patients following a known TB exposure and assessing whether polymorphisms of genes related to innate immunity are associated with TB infection |
| Bradford J Glavan |
MD | Pulmonary and Crit Care Fellow UW |
Understanding genetic variation in the Fas gene and associations with outcomes in acute lung injury |
| Karen Hinkley Stukovsky |
MS | Doctoral Candidate UW |
Assessing the impact of ambient air pollution on lung growth in children with cystic fibrosis |
| Peter Schoene | BA | Master Candidate Montana State Univ |
Assessing the impact of socioeconomic status and health related quality of life in patients with severe cystic fibrosis |
| Sunny Lim | MD | Pulmonary and Crit Care Fellow UW |
Impact of gender on outcome in cystic fibrosis |
| Kevin Winthrop | MD MPH | Asst Prof Oregon Health Sciences Center |
Validation of patient reported outcome measure in nontuberculous mycobacteria infection |
Past Mentees
Name |
Degree |
Current title |
Location |
| Jeremy Kahn | MD MS | Associate Professor | University of Pittsburgh |
| Joshua Saliman | MD | Private Practice | Seattle, WA |
| Laura Cecere | MD MS | Pulmonary Fellow | University of Washington |
| Colin Cooke | MD MS | Robert Wood Johnson Fellow |
University of Michigan |
| Cynthia Gries | MD MS | Assistant Professor | University of Pittsburgh |
| David Hotchkin | MD MS | Private Practice | Portland, OR |
| Antonia V Bennett | PhD | Postdoctoral Research Scholar |
Memorial Sloan-Kettering Cancer Center, NY |