research

Timothy R. Watkins

Assistant Professor of Medicine
Division of Pulmonary and Critical Care Medicine
Harborview Medical Center

MD, MSc

Faculty Web Page

Authored articles (PubMed)

Last updated:  September 26, 2012

 

Research Focus

Dr. Watkins leads a clinically-oriented translational research program focusing on identifying risk factors and modifiers of Acute Respiratory Distress Syndrome (ARDS), infection/sepsis, and multiple organ failure in the setting of critical illness and injury.  An area of focus involves examining how blood component transfusions might increase or decrease the occurrence of life-threatening complications, like ARDS, in critically ill patients. The Watkins laboratory is using a bedside-to-bench approach to examine clinical and biologic exposure characteristics of blood component therapies potentially linked to ARDS development.  Dr. Watkins is also active in multicenter clinical trials funded by the National Institutes of Health, including a trial designed to determine whether the use of aspirin prevents the development of Acute Lung Injury in at-risk patients.  More information is available at http://www.psbc.org/research/watkins.htm.

Relevant Publications

Watkins TR, Chien JW, Crawford SW. Graft versus host-associated pulmonary disease and other idiopathic pulmonary complications after hematopoietic stem cell transplant. Semin Respir Crit Care Med 2005;26(5):482-9.

Watkins TR, Nathens AB. TRALI: A New Case Definition, a New Epidemic? Am J Respir Crit Care Med 2007;176(9):839-40.

Watkins TR, Rubenfeld GD, Martin TR, Nester TA, Caldwell E, Billgren J, Ruzinski J, Nathens AB. Effects of leukoreduced blood on acute lung injury after trauma: a randomized controlled trial. Crit Care Med 2008;36:1493-9.

Cooke CR, Watkins TR, Kahn JM, Treggiari MM, Caldwell E, Hudson LD, Rubenfeld GD. The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury. Crit Care 2008;12:R134.

Cooke CR, Kahn JM, Watkins TR, Hudson LD, Rubenfeld GD. Cost-effectiveness of implementing low-tidal volume ventilation in patients with acute lung injury. Chest 2009;136:79-88.

Cooke CR, Erickson SE, Watkins TR, Matthay MA, Hudson LD, Rubenfeld GD. Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Crit Care Med 2010;38(6):1450-7.

Seymour CW, Kahn JM, Cooke CR, Watkins TR, Heckbert SR, Rea TD. Prediction of critical illness during out-of-hospital emergency care.  JAMA 2010;304(7):747-54. PMC

Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H, Hoth JJ, Mikkelsen ME, Gentile NT, Gong MN, Talmor D, Bajwa E, Watkins TR, Festic E, Yilmaz M, Iscimen R, Kaufman D, Esper AM,  Sadikot R, Douglas I, Sevransky J, Malinchoc M, on behalf of US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators. Early Identification of Patients at Risk of Acute Lung Injury: Evaluation of Lung Injury Prediction Score in a Multicenter Cohort Study. Am J Respir Crit Care Med 2011;183:462-70.

Stapleton RD, Martin TR, Weiss NS, Crowley JJ, Gundel SJ, Nathens AB, Ruzinski JY, Caldwell E, Curtis JR, Heyland DK, Watkins TR, Parsons PE, Martin JM, Wurfel MM, Hallstrand TS, Sims KA, Neff MJ . A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury. Crit Care Med 2011;39(7):1655-62.

Parsons EC, Hough CL, Seymour CW, Cooke CR, Rubenfeld GD, Watkins TR for the NHLBI ARDS Clinical Trials Network. Red blood cell transfusion and outcomes in patients with acute lung injury, sepsis, and shock. Critical Care 2011;15(5):R221.

Hayden SJ, Albert TJ, Watkins TR, Swenson ER. Anemia in Critical Illness: Insights into Etiology, Consequences, and Management. Am J Respir Crit Care Med 2012;185(10):1049-57.

Watkins TR, Nathens AB, Cooke CR, Psaty BM, Maier RV, Cuschieri J, Rubenfeld, GD. Acute Respiratory Distress Syndrome after Trauma: Development and Validation of a Predictive Model. Crit Care Med 2012;40(8):2295-2303.

 

Active Funding

Funding Source

Project Title

Investigator Role

Funding Dates

  NIGMS K23

Trauma and Acute Lung Injury: The Role of Red Blood Cell Storage and Transfusion

 PI

 2/2009-1/2014

  NHLBI UO1

LIPS-A: Lung Injury Prevention Study with Aspirin

 Co-I
(Site Investigator)

 9/2011-8/2014

Current Mentees

Name

Degree

Current Title

Project

  Lisa
  Vande Vusse
 MD   Senior Fellow,
  UW
 
  Associations between platelet storage time,
  platelet collection method, and idiopathic
  pneumonia syndrome after allogeneic
  hematopoietic stem cell transplantation

 

Past Mentees

Name

Degree

Current title

Location

 Elizabeth Parsons  MD MS  Senior Fellow  University of Washington

 

 

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