research


Division Faculty

Sina Gharib David Horne Eoin West Mark Wurfel
Collaborating Faculty

Jonathan Himmelfarb Thomas Hawn Gail Jarvik Deborah Nickerson Grant O'Keefe

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Genetic Epidemiology and Genomics

The Genetic Epidemiology and Genomics Program is focused on the identification of human genetic variation that alters risk for a wide variety of complex pulmonary and critical care-related diseases. These lines of research incorporate advanced molecular genetic tools ranging from low-throughput approaches such as PCR-based allelic discrimination assays to cutting-edge genome-wide sequencing techniques. Faculty and Collaborating Faculty employ a broad range of study designs from focused candidate gene approaches to genome-wide searches for common and rare risk alleles. Our groups also employ advanced techniques, transcriptomics, proteomics, and in molecular and cell biology to develop a mechanistic understanding of the observed genetic effects. In addition to genetic epidemiologic expertise within the division, we have well established ties within the Division of Medical Genetics and the Department of Genome Sciences and several important local resources including the Kidney Research Institute (KRI), the Northwest Institute for Genomic Medicine (NWIGM) and Seattle Variation Discovery Resource (SeattleSNPs).  Faculty are located throughout the UW system including the Harborview Research and Training Building, the main campus of the University of Washington Medical Center, and state-of-the facilities at the Center for Lung Biology at the South Lake Union campus of the University of Washington School of Medicine. Trainees may receive formal instruction in genetic epidemiologic techniques as part of the Master of Science degree in Genetic Epidemiology program offered through the School of Public Health.

Investigators in this program seek genetic and genomic factors that alter risk for disease and affect quantitative traits.  They are also developing new approaches to elucidate these genetic factors.  Click on the faculty links below to see further details and contact info:

Sepsis and Septic Shock

Acute Lung Injury (ALI)

Innate Immune Response

Grant O'Keefe

Grant O'Keefe

Thomas Hawn

Eoin West

Mark Wurfel

Eoin West

Mark Wurfel

Mark Wurfel

Acute Kidney Injury (AKI)

Sleep Disorders

Lung Function

Jonathan Himmelfarb

Sina Gharib

Sina Gharib

Mark Wurfel

 

 

Genome-scale Genotyping and Sequencing and Variation Discovery

Genetics of Complex Disease

Deborah Nickerson

Gail Jarvik


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