research

David Horne

Assistant Professor, Dept. of Medicine
Adjunct Assistant Professor, Dept. of Global Health

MD, MPH

Faculty Web Page

Authored articles (PubMed)

Last updated:  October 30, 2012

Research Focus

My broad research interests are in various aspects of tuberculosis, including epidemiology, genetic epidemiology, and best practices. I am particularly interested in the role of genetic variation in innate immunity pathways and susceptibility to different TB phenotypes. At present, I hold grants to prospectively investigate the role of human genetic variation in susceptibility to latent TB infection in a Seattle cohort and TB disease in a pediatric South African cohort.

I am interested in clinical studies in low resource settings. I am PI on a study of the prevalence of active TB among HIV-1-infected pregnant women in western Kenya and cofactors associated with TB disease and latent infection. Finally, I am involved in collaborative systematic reviews that are used to inform WHO guidelines on the management and diagnosis of TB. My scientific investigations are enhanced by my work as a clinician in the TB Control Program, Seattle & King County Public Health.

 

Relevant Publications

Horne DJ, Johnson CO, Oren E, Spitters C, Narita M. How Soon Can Smear Positive Tuberculosis Patients Be Released from Inpatient Isolation? Infection Control and Hospital Epidemiology, Jan 2010, 31(1); 78-84.

Horne DJ, Gooze L, Royce S, Narita M, Hopewell PC, Nahid P, Steingart KR. Sputum Monitoring During Tuberculosis Treatment for Predicting Outcome: A Systematic Review and Meta-Analysis, The Lancet Infectious Diseases, June 2010, 10(6); 387-94.

Horne DJ, Hubbard R, Narita M, Exarchos A, Park DR, Goss CH. Factors Associated with Mortality in Patients with Tuberculosis, BMC Infectious Diseases, 2010, 10; 258.

Bertholet S, Horne DJ, Laughlin EM, Savlov M, Tucakovic I, Ireton GC, Coler RN, Narita M, Reed SG. Effect of Chemotherapy on Whole Blood Cytokine Profiles to Mycobacterium tuberculosis Antigens in a Small Cohort of Pulmonary Tuberculosis Patients, Clinical and Vaccine Immunology, 2011 Jun 29. [Epub ahead of print]

Nahid P, Horne DJ, Jarlsberg LG, Reiner AP, Hopewell PC, Hulley SB, Bibbins-Domingo K. Racial Differences in Tuberculosis Infection in the CARDIA Study, Clinical Infectious Diseases, 2011, 53(3); 291-94.

Horne DJ, Spitters C, Narita M. Experience with the Use of Rifabutin for Treatment of Tuberculosis, The International Journal for Tuberculosis and Lung Disease, 2011 Nov; 15(11):1485-90.

Horne DJ, Randhawa AK, Chau TTH, Bang ND, Hieu NT, Farrar JJ, Dunstan SJ, Hawn TR. Common Polymorphisms in the PKP3-SIGIRR-TMEM16J Gene Region Are Associated with Susceptibility to Tuberculosis. Journal of Infectious Diseases, 2012 Feb; 205(4): 586-594.

Baker AR, Qiu F, Randhaw AK, Horne DJ, Adams, MD, Shey M, Bamholtz-Sloan J, Mayanja-Kizza H, Kaplan G, Hanekom WA, Boom WH, Hawn TR, Stein CM. Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap Data. PLoS One, 2012 Oct; 7(10): e47597. doi:10.1371/journal.pone.0047597.

Horne DJ, Campo M, Ortiz JR, Oren E, Arentz M, Crothers K, Narita M. Association between smoking and latent tuberculosis in the U.S. population. PLoS One, in press.

Horne DJ, Pinto L, Arentz M, Lin SYG, Desmond E, Flores LL, Steingart KR, Minion J. Diagnostic Accuracy and Reproducibility of WHO-endorsed Phenotypic Drug Susceptibility Testing Methods for First- and Second-line Anti-tuberculosis Drugs: A Systematic Review and Meta-Analysis. Journal of Clinical Microbiology, in press.

 

Active Funding

Funding Source

Project Title

Investigator Role

Funding Dates

NIH/NIAID K23

Tuberculosis infection and genetic variation

PI

5/2010 - 4/2015

Firland Foundation

Tuberculosis in HIV-infected Pregnant Women: A Pilot Study

PI

7/2012 - 6/2013

American Thoracic Society/Merck Unrestricted Research Award   

Copy number variation and the immune response to TB

PI

10/2012 - 9/2014

Centers for Disease Control and Prevention

TB Epidemiologic Studies Consortium

Co-Investigator

11/2012 - 10/2022

 

 


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