research

Kristina Crothers David Horne Justin Ortiz Eoin West
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Global Health Program

An expanding cadre of Division faculty engages in pulmonary and critical care research with an international perspective. Seattle is a hotbed of global health activity and the University of Washington strongly encourages global citizenship. Members of the Division within the Global Health Program participate in various other Division research programs, bringing a range of expertise to global research activities. Members collaborate closely with faculty in the Division of Allergy and Infectious Diseases, the Department of Global Health, and organizations such as PATH, performing clinical and translational research on several continents. The International Respiratory and Severe Illness Center (INTERSECT) is based within the division promotes cooperation between researchers, clinicians, and educators interested in global pulmonary and critical care medicine.

Kristina Crothers' research seeks to understand interactions between chronic, comorbid diseases and lung health, exemplified by studying the impact of HIV infection on the development and clinical course of lung diseases. She is particularly interested in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), lung cancer and bacterial pneumonia, given the prevalence of smoking among HIV-infected persons.

David Horne studies how host genetic variation is associated with tuberculosis phenotype in cohorts in Seattle, Uganda, and Vietnam. He is also developing collaborations with investigators in the Department of Global Health to assess the burden of tuberculosis in Kenyan children with severe febrile illnesses.

Justin Ortiz's research interest is the clinical epidemiology of respiratory infections. He collaborates with the CDC to study the burden of severe influenza virus infection. With PATH, a Seattle-based non-profit organization, he leads surveillance for an influenza vaccine clinical effectiveness trial in West Africa. He also is conducting a substudy within the vaccine trial to assess whether exposure to indoor air pollution increases the risk of influenza virus infection.

Eoin West’s primary research focus is innate immunity in bacterial respiratory infections and sepsis, conditions that dramatically impact the poorest populations worldwide. In association with colleagues in Bangkok and Ubon Ratchathani, Thailand, he studies host defense in melioidosis, an often lethal tropical infection, as well as in invasive Staphylococcus aureus infection. In collaboration with the WHO, a second research focus is developing and testing the effectiveness of severe illness management guidelines for low resource settings.

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