research

William C. Parks

Professor
Director, Center for Lung Biology
Affiliate Investigator, Benaroya Research Institute

PhD

Faculty Web Page

Last Updated:  January 5, 2011


    William Parks













Background

Dr. Parks received his PhD in Anatomy from the Medical College of Wisconsin in 1982 and did postdoctoral training in cancer biology at Michigan State University from 1982 to 1985 and in extracellular matrix and lung biology at Washington University from 1985 to1986.
In 1986 Dr. Parks was appointed to faculty in the Departments of Medicine (Dermatology) and Cell Biology and Physiology at Washington University, and in 2000 he was promoted to full Professor in the Departments of Pediatrics (Allergy and Pulmonary Medicine), Cell Biology & Physiology, and Medicine. While at Washington University, Dr. Parks established and administered a large Morphology Core, directed the Developmental Lung Biology Program, which supported scientific cores, educational events, symposia, and fellowships, and was the Principal Investigator of an NIAMS Program Project Grant on basic skin biology.

In 2004, Dr. Parks relocated to the University of Washington and soon thereafter established the Center for Lung Biology at the South Lake Union. Among his national responsibilities, Dr. Parks is the recent President of the American Society for Matrix Biology, an Associate Editor of the American Journal of Cell & Molecular Respiratory Biology, chair of the NIH Lung Injury, Repair, and Remodeling (LIRR) Study Section, and on the board of trustees of the Puget Sound Blood Center. In the past, he chaired the Cell Structure and Metastasis Committee of the American Cancer Society, chaired two Gordon Research Conferences, and served on or chaired several study sections.



Research Focus

Research in our lab focuses on the role of specific matrix Parks Research 1
metalloproteinases(MMP) in immunity and tissue repair and on the
control of elastin production in lung and vascular tissue. We have determined that MMPs serve distinct, non-overlapping functions in
several distinct processes of innate immunity, such as the activation
state of neutrophils and macrophages. Our goal is to understand mechanism, that is, to identify the physiologic protein substrates of individual MMPs whose cleavage regulates specific processes, such as neutrophil recruitment, cell migration, etc. All project include a hefty use of mouse models, including knock strains we have developed, and incorporate a variety of cellular, molecular, biochemical, and systems approaches.

 

Relevant Publications

Li Q, PW Park, CL Wilson, WC Parks. 2002. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell 111:635-646.

Parks WC, CW Wilson, YS Lopéz-Boado. 2004. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 4:617-629.

Ra HJ, WC Parks. 2007. Control of matrix metalloproteinase catalytic activity. Matrix Biol 26:587-596.

Gill SE, WC Parks. 2008. Metalloproteinases and their inhibitors: regulators of wound healing. Int J Biochem Cell Biol 40:1334-47.

Kim J, Swee M, WC Parks. 2009. Cytosolic SYT/SS18 isoforms are actin-associated proteins that function in matrix-specific adhesion. PLoSOne 4:e6455.

Ra HJ, S Harju-Baker, F Zhang, RJ Lindardt, CL Wilson, WC Parks. 2009. Regulation of matrilysin (mmp-7) zymogen activation and substrate-specific activity by sulfated glycosaminoglycans. J Biol Chem 284:27924-27932.

Chen P, WC Parks. 2009. Role of matrix metalloproteinases in epithelial migration. J Cell Biochem 108:1233-43

Chen P, LE Abacheri, ST Nadler, Y Wang, Q Li, WC Parks. 2009. Matrilysin shedding of syndecan-1 facilitates re-epithelialization by altering b1 integrin activation. PLoSOne 4:e6565.

Manicone AM, TP Birkland, Y Yang, T Betsuyaku, J Lohi, SJ Skerrett, WC Parks. 2009. Epilysin (MMP28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia. J Immunol 182:3866-3876.

Gill SE, I Huizar, EM Bench, Y Wang, R Khokha, WC Parks. 2010. Tissue inhibitor of metalloproteinase 3 (TIMP3) regulates resolution of inflammation following acute lung injury. Am J Pathol 176:64-73.

 

Active Funding

Funding Source

Project Title

Invesigator
Role

Funding Dates

NIH R01 HL082658

Epithelial Control of Neutrophil Activation

PI

4/2007-3/2012

NIH P01 HL029594

Mechanisms in the Remodeling of Lung Structure

Project PI

9/2008-8/2013

NIH R21 AI083487

Metalloproteinases in Mucosal Immunity

PI

5/2009-4/2011

NIH P01 HL098067

Regulation of Pulmonary Inflammation by Leukocytes and Extracellular Matrix

Project PI

7/2010-6/2015

NIH R01 HL089455

MMP10 Control of Macrophage Activation in COPD

PI

12/2010-11/2015

NIH P30 DK089507

Translational Research Center toExpedite Novel Therapies in Cystic Fibrosis

Core Director

7/2010-6/2015

Cystic Fibrosis
Foundation

Research Development Program

Core Director

10/2007-9/2016

NIH R01 DK082560

Disorganization of Elastin Matrix Mediates Erectile Dysfunction

Co-PI

11/2008-10/2013

 

Current Mentees

Name

Position

Project & Funding

Anne Manicone, MD

Assistant Prof

Macrophage activation by sterols and MMPs
NIH K08, Howard Hughes Career Devel Award

Sean Gill, PhD

Acting Instructor

Resolution of inflammation and fibrosis
Parker B. Francis Fellowship

Peter Chen, MD

Assistant Prof

Mechanisms of re-epithelialization
NIH K08, ALA and AHA Research Grants

Jane Yoo, MD

Instructor
Dermatology

MMPs and integrins in atopic dermatitis
NIH NRSA, Derm Found Career Devel Award

Michelle Lin, PhD

Postdoc

Proteomic identification of MMP substrates
NIH NRSA

Samuel Nadler, MD PhD

Fellow

Epithelial control of neutrophil activation
NIH NRSA

Maryam Rohani, PhD

Postdoc
Dermatology

Signaling in re-epithelialization
NIH NRSA

Seth Hartung, MD PhD

Fellow

Host response to biofilm bacterial communities
Institutional T32

Laurie Eldredge, MD PhD

Resident, Pediatrics

Elastin production in bronchopulmonary displasia
Integrated Research Pathway

 

Past Mentees

Name

Period

Current Position

Location

Mona Ståhle, MD PhD

89–91

Professor of Dermatology
Chair of Medicine (past)

Karolinska Institute
Karolinska Hospital

Glenn Doyle, PhD

89–94

Instructor

University of Pennsylvania

Barry Sudbeck, PhD

89–93

Staff Scientist

Entelos Inc

Katherine Lee, MD PhD

89–94

Ophthalmologist

Private practice

Ulpu Saarialho-Kere, MD PhD

91–94

Professor of Dermatology

University of Helsinki

Richard Pierce, PhD

91–92

Assoc Prof Pulmonary

Washington University

Mei Swee, PhD

93–95

Research Scientist

University of Washington

Brian Pilcher, PhD

95–99

Director of Research

Bioform Medical Inc

Carole Wilson, PhD

96–00

Res Assist Prof of Pathol

University of Washington

Yolanda López-Boado, PhD

96–99

Staff Scientist

Glaxo-Smith-Kline

Mancong Zhang, MD PhD

96–99

Dermatopathologist

Private practice

Hui-Qing Yin, PhD

96–04

Research Scientist

Washington University

Jo Ann Dumin, PhD

96–00

Staff Scientist

Pfizer

Jouko Lohi, MD, PhD

97–99

Assoc Prof of Pathology

University of Helsinki

John McGuire, MD

99–08

Assoc Prof of Pediatrics

University of Washington

Eric Choi, MD

00–04

Assoc Prof of Surgery

Washington University

Hyun Ra, PhD

00–06

Postdoctoral Fellow

Wistar Institute, Univ Pennsylvania

Carolyn Cannon, MD

02–04

Assoc Prof of Pediatrics

Univ Texas Southwestern

Jaehong Kim

02–07

Postdoctoral Fellow

University of California San Diego

Sean Kassim, PhD

04–08

Pharmacologist

FDA, HHS

Isham Huizar, MD

04–08

Assist Prof Pulmonary

East Carolina University

Lana Hanford, PhD

05–06

Assist Prof of Biology

Pierce College

Susanna Harju, PhD

05–10

Research Scientist

University of Washington

Tamara Pozos, MD, PhD

07–08

Attending Physician

Children’s Hospital of Minnesota

Anne Chen, MD

07–10

Attending Physician

Swedish Hospital


 



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