research
Lynn M. Schnapp
Professor of Medicine, Pulmonary and Critical Care Medicine
Adjunct Professor, Dept of Biobehavioral Nursing and Health Systems, School of Nursing
MD
Last Updated: September 22, 2010
Research Focus
Our lab is focused on the processes that govern acute lung injury and its resol
ution. In particular, we are interested in why lung injury resolves under certain circumstances (i.e. Adult Respiratory Distress Syndrome) and progresses to end-stage fibrosis in other circumstances (i.e. Idiopathic Pulmonary Fibrosis). To examine these questions, we use different mouse models of lung injury to examine the regulation of matrix remodeling and the role of the alveolar myofibroblasts in the resolution of fibrosis. In collaboration with faculty in Dept of Bioengineering, we are developing novel drug delivery systems targeting the lung that will facilitate the resolution of lung injury.
To complement these studies, we are analyzing bronchoalveolar lavage fluid from 
patients with acute lung injury and other lung diseases using cutting-edge methodologies in proteomics to identify new pathways in lung injury.
Relevant Publications
Gharib SA, Nguyen E, Altemeier WA, Shaffer SA, Doneanu CE, Goodlett DR, Schnapp LM. Of mice and men: comparative proteomics of bronchoalveolar fluid. Eur Respir J. 2010 Jun;35(6):1388-95
Benjamin JT, Gaston DC, Halloran BA, Schnapp LM, Zent R, Prince LS. The role of integrin alpha8beta1 in fetal lung morphogenesis and injury. Dev Biol. 2009 Nov 15;335(2):407-17
Schnapp LM, Vaught M, Park DR, Rubenfeld G, Goodman RB, Hudson LD. Implementation and impact of a translational research training program in pulmonary and critical care medicine. Chest. 2009
Choi JE, Lee SS, Sunde DA, Huizar I, Haugk KL, Thannickal VJ, Vittal R, Plymate SR, Schnapp LM. Insulin-like growth factor-I receptor blockade improves outcome in mouse model of lung injury. Am J Respir Crit Care Med. 2009 Feb 1;179(3):212-9
Smith L, Wagner TE, Huizar I, Schnapp LM. uPARAP expression during murine lung development. Gene Expr Patterns. 2008 Sep;8(7-8):486-93
Liu L, Schwartz B, Tsubota Y, Raines E, Kiyokawa H, Yonekawa K, Harlan JM, Schnapp LM. Cyclin-dependent kinase inhibitors block leukocyte adhesion and migration. J Immunol. 2008 Feb 1;180(3):1808-17
Schnapp LM, Donohoe S, Chen J, Sunde DA, Kelly PM, Ruzinski J, Martin T, Goodlett DR. Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury. Am J Pathol. 2006 Jul;169(1):86-95
Members of the Schnapp Lab
Current Lab Members
Name |
Degree |
Project |
Mike Bundesmann, MD
|
Postdoctoral Fellow |
Role of uPARAP in lung injury and matrix remodeling |
Yu-Hua Chow, PhD
|
Research Scientist, Lab Manager |
Novel methods to target lung fibroblasts |
Chi Hung, MD
|
Postdoctoral Fellow |
Therapeutics for resolution of lung injury |
Tae-Hyung Kim, MD
|
Visiting Scholar |
Mechanisms of hyperoxia-induced lung injury |
Paul Morales, BS
|
Research Scientist |
Effect of hyperoxia and fibroblast differentiation |
Steve Palazzo |
Graduate Student |
Biomarkers in ventilator-associated pneumonia |
Candace Cameroon
|
Undergraduate Student |
Transgenic mouse genotyping |
Schnapp Alumni
Active Funding
Funding Source |
Project Title |
Investigator Role |
Funding Dates |
NIH/NHLBI RO1 |
Matrix remodeling in the lung during HIV infection |
PI |
9/2005-8/2011 |
NIH K24 |
Proteomic-based approach to ventilator-associated pneumonia |
PI |
3/2007-3/2011 |
AHA Grant-in-Aid |
Role of the collagen receptor uPARAP in lung injury and repair |
PI |
7/2009-6/2012 |
Life Science Discovery Grant |
Center for Intracellular Delivery of Biologics |
Project Leader |
8/2009-7/2013 |
NIH F32 |
uPARAP and acute lung injury |
Mentor (Bundesman) |
7/2010-6/2012 |
NIH F31 |
An early diagnostic marker for VAP |
Mentor (Palazzo) |
6/2009-5/2011 |