research

Lynn M. Schnapp

Affiliate Professor of Medicine, Pulmonary and Critical Care Medicine
Adjunct Professor, Dept of Biobehavioral Nursing and Health Systems, School of Nursing

MD

Faculty Web Page

Last Updated:  September 22, 2010

 

The Schnapp Lab

 

Research Focus

Our lab is focused on the processes that govern acute lung injury and its resolution. In particular, we are interested in why lung injury resolves under certain circumstances (i.e. Adult Respiratory Distress Syndrome) and progresses to end-stage fibrosis in other circumstances (i.e. Idiopathic Pulmonary Fibrosis). To examine these questions, we use different mouse models of lung injury to examine the regulation of matrix remodeling and the role of the alveolar myofibroblasts in the resolution of fibrosis. In collaboration with faculty in Dept of Bioengineering, we are developing novel drug delivery systems targeting the lung that will facilitate the resolution of lung injury.

To complement these studies, we are analyzing bronchoalveolar lavage fluid from patients with acute lung injury and other lung diseases using cutting-edge methodologies in proteomics to identify new pathways in lung injury.

 

 

Relevant Publications

Gharib SA, Nguyen E, Altemeier WA, Shaffer SA, Doneanu CE, Goodlett DR, Schnapp LM. Of mice and men: comparative proteomics of bronchoalveolar fluid. Eur Respir J. 2010 Jun;35(6):1388-95

Benjamin JT, Gaston DC, Halloran BA, Schnapp LM, Zent R, Prince LS. The role of integrin alpha8beta1 in fetal lung morphogenesis and injury. Dev Biol. 2009 Nov 15;335(2):407-17

Schnapp LM, Vaught M, Park DR, Rubenfeld G, Goodman RB, Hudson LD. Implementation and impact of a translational research training program in pulmonary and critical care medicine. Chest. 2009

Choi JE, Lee SS, Sunde DA, Huizar I, Haugk KL, Thannickal VJ, Vittal R, Plymate SR, Schnapp LM. Insulin-like growth factor-I receptor blockade improves outcome in mouse model of lung injury. Am J Respir Crit Care Med. 2009 Feb 1;179(3):212-9

Smith L, Wagner TE, Huizar I, Schnapp LM. uPARAP expression during murine lung development. Gene Expr Patterns. 2008 Sep;8(7-8):486-93

Liu L, Schwartz B, Tsubota Y, Raines E, Kiyokawa H, Yonekawa K, Harlan JM, Schnapp LM. Cyclin-dependent kinase inhibitors block leukocyte adhesion and migration. J Immunol. 2008 Feb 1;180(3):1808-17

Schnapp LM, Donohoe S, Chen J, Sunde DA, Kelly PM, Ruzinski J, Martin T, Goodlett DR. Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury. Am J Pathol. 2006 Jul;169(1):86-95

 

Lab Members

Members of the Schnapp Lab

 

Current Lab Members

Name

Degree

Project

Mike Bundesmann, MD

Mike Bundesmann

Postdoctoral Fellow

Role of uPARAP in lung injury and matrix remodeling

Yu-Hua Chow, PhD

Yu-Hua Chow

Research Scientist, Lab Manager

Novel methods to target lung fibroblasts

Chi Hung, MD

Chi Hung

Postdoctoral Fellow

Therapeutics for resolution of lung injury

Tae-Hyung Kim, MD

Tae-Hyung Kim

Visiting Scholar

Mechanisms of hyperoxia-induced lung injury

Paul Morales, BS

Paul Morales

Research Scientist

Effect of hyperoxia and fibroblast differentiation

Steve Palazzo

Graduate Student

Biomarkers in ventilator-associated pneumonia

Candace Cameroon

Candace Cameroon

Undergraduate Student

Transgenic mouse genotyping

 

Schnapp Alumni

Schnapp Alumni

 

Active Funding

Funding Source

Project Title

Investigator Role

Funding Dates

NIH/NHLBI RO1

Matrix remodeling in the lung during HIV infection

PI

9/2005-8/2011

NIH K24

Proteomic-based approach to ventilator-associated pneumonia

PI

3/2007-3/2011

AHA Grant-in-Aid

Role of the collagen receptor uPARAP in lung injury and repair

PI

7/2009-6/2012

Life Science Discovery Grant

Center for Intracellular Delivery of Biologics

Project Leader

8/2009-7/2013

NIH F32

uPARAP and acute lung injury

Mentor (Bundesman)

7/2010-6/2012

NIH F31

An early diagnostic marker for VAP

Mentor (Palazzo)

6/2009-5/2011


 



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