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Prader-Willi syndrome Description Prader-Willi syndrome is a genetic disorder caused by partial deletion of chromosome 15 (paternal) or disomy (maternal). Children with Prader-Willi syndrome have mental retardation and abnormal food-related behaviors. Prader-Willi syndrome is characterized by feeding problems during infancy, and hyperphagia in childhood and adolescence, often resulting in obesity. Potential feeding problems can include:
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