Cattolico Laboratory

Evolution, physiology, and molecular biology of the algae



Hunsperger, H.M., Randhawa, T., & Cattolico, R.A. (2015). Extensive horizontal gene transfer, duplication, and loss of chlorophyll synthesis genes in the algae. BMC Evolutionary Biology 15: 16. Link


Hovde, B.T., Starkenburg, S.R., Hunsperger, H.M., Mercer, L.D., Deodato, C.R., Jha, R.K., Chertkov, O., Monnat, R.J., & Cattolico, R.A. (2014). The mitochondrial and chloroplast genomes of the haptophyte Chrysochromulina tobin contain unique repeat structures and gene profiles. BMC Genomics 15: 604. Link

Keeling, P.J., Burki, F., Wilcox, H.M., Allam, B., Allen, E.E., Amaral-Zettler, L.A., Armbrust, E.V., Archibald, J.M., Bharti, A.K., Bell, C.J., Beszteri, B., Bidle, K.D., Cameron, C.T., Campbell, L., Caron, D.A., Cattolico, R.A., et al. (2014). The Marine Microbial Eukaryote Transcriptome Sequencing Project (MMETSP): Illuminating the functional diversity of eukaryotic life in the oceans through transcriptome sequencing. PLoS Biology 12(6): e1001889. Link

Starkenburg, S., Kwon, K., Jha, R., McKay, C., Jacobs, M., Chertkov, O., Twary, S., Rocap, G., & Cattolico, R.A. (2014). A pangenomic analysis of the Nannochloropsis organellar genomes reveals novel genetic variations in key metabolic genes. BMC Genomics 15: 212. Link


Tobin, L., Grunbaum, D., Patterson, J., & Cattolico, R.A. (2013). Behavioral and physiological changes during benthic-pelagic transition in the harmful alga, Heterosigma akashiwo: Potential for rapid bloom formation. PLoS One 8(10): e76663. Link

Bigelow, N., Barker, J., Ryken, S., Patterson, J., Hardin, W., Barlow, S., Deodato, C., & Cattolico, R.A. (2013). Chrysochromulina sp.: A proposed lipid standard for the algal biofuel industry and its application to diverse taxa for screening lipid content. Algal Research 2(4): 385-393. 2013


Park, B.S., Baek, S.H., Ki, J-S., Cattolico, R.A., & Han, M-S. (2012). Assessment of EvaGreen-based quantitative real-time PCR assay for enumeration of the microalgae Heterosigma and Chattonella (Raphidophyceae). Journal of Applied Phycology 24(6): 1555-1567. Link

Barker, J.P., Cattolico, R.A., & Gatza, E. (2012). Multiparametric analysis of microalgae for biofuels using flow cytometry. BD Biosciences Technical White Paper. Link


Bigelow, N.W., Hardin, W.R., Barker, J.P., Ryken, S.A., MacRae, A.C., & Cattolico, R.A. (2011). A comprehensive GC-MS Sub-microscale assay for fatty acids and its applications. JAOCS, Journal of the American Oil Chemists’ Society 88(9): 1329-1338. 2011pdf

Tobin, E.D., Grünbaum, D., & Cattolico, R.A. (2011). Pelagic-benthic transition of the harmful alga, Heterosigma akashiwo: Changes in swimming and implications for benthic cell distributions. Harmful Algae 10(6): 619-628. Link


Cooper, M. S., Hardin, W. R., Petersen, T. W., Cattolico, R. A. (2010). Visualizing green oil in live algal cells. Journal of Bioscience and Bioengineering, v109 n2 (201002): 198-201. Link

Karol, K., Jacobs, M., Zhou, Z., Sims, E., Gillett, W., & Cattolico R.A. (2010). Organellar genome evolution: comparative analysis of complete mitochondrial and chloroplast genome sequences from geographically distinct strains of Heterosigma akashiwo. In J. Wee, P. Siver, and A-M Lott (Eds.), Chrysophytes : from fossil perspectives to molecular characterizations; proceedings of the Seventh International Chrysophyte Symposium Connecticut College, New London, Connecticut, U.S.A., June 22 – 27, 2008 (pp. 261-282). Stuttgart, Germany: Nova Hedwigia. Link

Ong, H.C., Wilhelm, S.W., Gobler, C.J., Bullerjahn, G., Jacobs, M.A., McKay, J., Sims, E.H., Gillett, W.G., Zhou, Y., Haugen, E., Rocap, G., & Cattolico, R.A. (2010). Analyses of the complete chloroplast genome sequences of two members of the pelagophyceae: Aureococcus anophagefferens CCMP1984 and Aureoumbra lagunensis CCMP1507. Journal of Phycology 46(3): 602-615. Link


Lakeman, M.B., von Dassow, P. & Cattolico, R. A. (2009). The strain concept in phytoplankton ecology. Harmful Algae 8(5): 746-758. 2009pdf


Cattolico, R.A., Jacobs, M.A., Zhou, Y., Chang, J., Duplessis, M., Lybrand, T., McKay, J., Ong, H.C., Sims, E., & Rocap, G. (2008). Chloroplast genome sequencing analysis of Heterosigma akashiwo CCMP452 (West Atlantic) and NIES293 (West Pacific) strains. BMC Genomics 9: 211. Link


Duplessis, M. R., Karol, K. G., Adman, E. T., Choi, L. Y. S., Jacobs, M. A., & Cattolico, R. A. (2007). Chloroplast His-to-Asp signal transduction: a potential mechanism for plastid gene regulation in Heterosigma akashiwo (Raphidophyceae). BMC Evolutionary Biology 7, 70. Link

Lakeman, M. B., & Cattolico, R. A. (2007). Cryptic diversity in phytoplankton cultures is revealed using a simple plating technique. J. Phycol. 43, 662-774. Link


Bearon, R. N., Grunbaum, D., & Cattolico, R. A. (2006). Effects of salinity structure on swimming behavior and harmful algal bloom formation in Heterosigma akashiwo, a toxic raphidophyte. Marine Ecology Progress Series 306, 153-163. 2006pdf


Bearon, R. N., Grunbaum, D., & Cattolico, R. A. (2004). Relating cell-level swimming behaviors to vertical population distributions in Heterosigma akashiwo (Raphidophyceae), a harmful alga. Limnology and Oceanography 49, 607-613. 2004pdf


Han, M-S., Kim, Y-P., & Cattolico, R.A. (2002). Heterosigma akashiwo (Raphidophyceae) resting cell formation in batch culture: Strain identity versus physiological response. Journal of Phycology 38(2): 304-317. Link


Jacobs, M.A. & Cattolico, R.A. (2001). Signal transduction in chromophytic algae: A hypothesis. In: Siver, P.A & J.L. Wee (eds). Chrysophytes and related organisms: topics and issues, Proceedings of the Fifth International Chrysophyte Symposium. Nova Hedwigia Beiheft 122: 211-229. Dr. E. Nagele, Gebruder Borntraeger Verlagsbuchhandlung, Stuttgart, Germany. Link


Jacobs, M. A., Connell, L., & Cattolico, R. A. (1999). A conserved His-Asp signal response regulator-like gene in Heterosigma akashiwo chloroplasts. Plant Molecular Biology 41, 645-655. Link


Cattolico, R. A., Han, M. S., Connell, L., Welling, K., Hatheway, W., & Waaland, J. R. (1998). Heterosigma carterae: A model system for harmful algal bloom studies. Journal of Phycology 34, 11-12.

Hariharan, T., Johnson, P. J., & Cattolico, R. A. (1998). Purification and characterization of phosphoribulokinase from the marine chromophytic alga Heterosigma carterae. Plant Physiol 117, 321-9. Link

Jacobs, M. A., Connell, L. B., & Cattolico, R. A. (1998). His-Asp signal transduction in chloroplasts of Heterosigma carterae. Journal of Phycology 34, 26.

Valentin, K., Fischer, S., & Cattolico, R. A. (1998). The chloroplast bchI gene encodes a subunit of magnesium chelatase in the marine heterokont alga Heterosigma carterae. European Journal of Phycology 33, 113-120. Link


Connell, L., Welling, K., & Cattolico, R. A. (1997). Algal organic metabolites affect survival of Pacific oysters, Crassostrea gigas, larvae. Journal of Shellfish Research 16, 493-501.

Doran, E., & Cattolico, R. A. (1997). Photoregulation of Chloroplast Gene Transcription in the Chromophytic Alga Heterosigma carterae. Plant Physiol 115, 773-781. Link


Connell, L. & Cattolico, R.A. (1996). Fragile algae: Axenic culture of field-collected samples of Heterosigma carterae. Marine Biology 125(2): 421-426. Link


Hardison, L. K., Boczar, B. A., & Cattolico, R. A. (1995). psbA in the marine chromophyte Heterosigma carterae: evolutionary analysis and comparative structure of the D1 carboxyl terminus. American Journal of Botany 82, 893-902. Link

Mangahas, J. L., Cattolico, R. A., & Reynolds, A. E. (1995). Analysis of Heterosigma carterae (CHROMOPHYTA, RAPHIDOPHYCEAE) chloroplast rpoB gene sequence. Journal of Phycology 31, 808-812. Link


Delaney, T. P., Hardison, L., & Cattolico, R. A. (1994). Evolution of plastid genomes: Inferences from discordant molecular phylogenies. In Chrysophyte Algae: Ecology, Phylogeny and Development (Sandgren, C., Smol, J. & Kristiansen, J., eds.). Cambridge University Press, England. Link

Reynolds, A. E., Chesnick, J. M., Woolford, J., & Cattolico, R. A. (1994). Chloroplast encoded thioredoxin genes in the red algae Porphyra yezoensis and Griffithsia pacifica: evolutionary implications. Plant Mol Biol 25, 13-21. Link


Chesnick, J. M., & Cattolico, R. A. (1993). Isolation of DNA from eukaryotic algae. Methods Enzymol 224, 168-76. Link

Reynolds, A. E., McConaughy, B. L., & Cattolico, R. A. (1993). Chloroplast genes of the marine alga Heterosigma carterae* are transcriptionally regulated during a light/dark cycle. Mol Mar Biol Biotechnol 2(3), 121-128. 1993pdf

Valentin, K., Cattolico, R. A., & Zetsche, K. (1993). Phylogenetic origin of the plastids. In Origins of Plastids: Symbiogenesis, Prochlorophytes and the Origins of Chloroplasts (Lewin, R., ed.), pp. 193-222. Chapman and Hall, New York/London. Link

Wee, J., Chesnick, J., & Cattolico, R. A. (1993). Partial characterization of the chloroplast genome from the chromophytic alga Synura petersenii (Synurophyceae). Journal of Phycology 29, 96-99. Link


Hardison, L. K., Boczar, B. A., Reynolds, A. E., & Cattolico, R. A. (1992). A description of the Rubisco large subunit gene and its transcript in Olisthodiscus luteus. Plant Mol Biol 18, 595-9. Link

Li, N., & Cattolico, R. A. (1992). Ochromonas danica (Chrysophyceae) chloroplast genome organization. Molecular Marine Biology and Biotechnology 1, 165-174.

Reynolds, A. E., McConaughy, B., & Cattolico, R. A. (1992). Marine algal chloroplast genes are transcriptionally regulated during a Diel cycle. Molec Marine Biology and Biotechnology 2, 121-128.

Shivji, M. S., Li, N., & Cattolico, R. A. (1992). Structure and organization of rhodophyte and chromophyte plastid genomes: implications for the ancestry of plastids. Mol Gen Genet 232, 65-73. Link


Boczar, B. A., & Cattolico, R. A. (1991). Characterization of satellite DNA from three marine dinoflagellates (Dinophyceae): Glenodinium sp. and two members of the toxic genus, Protogonyaulax. Plant Physiol 97, 613-618. 1991pdf

Chesnick, J., Kugrens, P., & Cattolico, R. A. (1991). The validity of morphological characteristics in determination of Cryptomonad Phyletics: Mitochondrial DNA assessment. Molec Marine Biology 1, 18-26.

Delaney, T. P., & Cattolico, R. A. (1991). Sequence and secondary structure of chloroplast 16S rRNA from the chromophyte alga Olisthodiscus luteus, as inferred from the gene sequence. Nucleic Acids Res 19, 6328. Link

Li, N., Hedberg, M.F., & Cattolico, R.A. (1991). Chloroplast DNA heterogeneity in Monodus sp. (Eustigmatophyta). Current Genetics 20(1-2): 157-159. Link


Cattolico, R. A., & Loiseaux-de Goer, S. (1990). Analysis of chloroplast evolution and phylogeny: a molecular approach. In The Chromophyte Algae: Problems and Perspectives (Green, J.C., Leadbeater, B.S.C., and Diver, W.L., eds.), Vol. 38, pp. 85-100. Oxford University Press, Oxford. Link

Newman, S., & Cattolico, R. A. (1990). Biochemistry and evolution of Rubisco in algal systems. Photosynthesis Research 26, 69-85.


Boczar, B. A., Delaney, T. P., & Cattolico, R. A. (1989). Gene for the ribulose-1,5-bisphosphate carboxylase small subunit protein of the marine chromophyte Olisthodiscus luteus is similar to that of a chemoautotrophic bacterium. Proc Natl Acad Sci USA 86, 4996-9. 1989pdf

Delaney, T. P., & Cattolico, R. A. (1989). Chloroplast ribosomal DNA organization in the chromophytic alga Olisthodiscus luteus. Curr Genet 15, 221-9. Link

Newman, S., DeRocher, J., & Cattolico, R. A. (1989). Analysis of Chromophytic and Rhodophytic Ribulose-1,5-Bisphosphate Carboxylase Indicates Extensive Structural and Functional Similarities among Evolutionarily Diverse Algae. Plant Physiol 91, 939-946. 1989pdf


Boczar, B.A., Beitler, M.K., Liston, J., Sullivan, J.J., & Cattolico, R.A. (1988). Paralytic shellfish toxins in Protogonyaulax tamarensis and Protogonyaulax catenella in axenic culture. Plant Physiology 88(4): 1285-1290. Link

Newman, S., & Cattolico, R. A. (1988). Synthesis of active Olisthodiscus luteus ribulose 1,5 bisphosphate carboxylase in E. coli. Plant Mol Biol 11, 821-831. Link


Li, N., & Cattolico, R. A. (1987). Chloroplast genome characterization in the red alga Griffithsia pacifica. Molec Gen Genet 209, 343-351. Link

Newman, S., & Cattolico, R. A. (1987). Structural and functional relatedness of chromophytic and rhodophytic RuBP carboxylase enzymes. Prog in Photosyn Res 4, 671-674.

Newman, S., & Cattolico, R. A. (1987). Structural, functional, and evolutionary analysis of ribulose 1,5 bisphosphate carboxylase from the chromophytic alga Olisthodiscus luteus. Plant Physiol 84, 483-490. 1987pdf


Cattolico, R. A. (1986). Chloroplast evolution in algae and land plants. Trends in Ecology and Evolution 1, 64-67. Link

Cattolico, R. A., Aldrich, J. K., Bressler, S., Ensland-Talbot, D., Newman, S., & Reith, M. E. (1986). Chloroplast DNA in the Chrysophyceae: copy number, packaging, and gene expression in Olisthodiscus luteus. In Chrysophytes: Aspects and Problems (Anderson, J. K. a. R., ed.), pp. 143-162. Cambridge University Press, England. Link

Reith, M. E., & Cattolico, R. A. (1986). The inverted repeat of Olisthodiscus luteus ctDNA contains the genes for both subunits of RuBPcase and the 32,000 QB protein: phylogenetic implication. Proc Natl Acad Sci USA 83, 8599-8603.


Cattolico, R. A. (1985). Chloroplast biosystematics: chloroplast DNA as a molecular probe. Biosystems 18, 299-306. Link

Reith, M. E., & Cattolico, R. A. (1985). In vitro chloroplast protein synthesis by the chromophytic alga Olisthodiscus luteus. Biochemistry 24, 2550-6. Link

Reith, M. E., & Cattolico, R. A. (1985). In vivo chloroplast protein synthesis by the chromophytic alga Olisthodiscus luteus. Biochemistry 24, 2556-2561.Link

Reith, M. E., & Cattolico, R. A. (1985). Cell cycle analysis of polypeptides synthesized by the chromophytic alga Olisthodiscus luteus. Plant Physiol 79, 231-236. 1985pdf


Aldrich, J. K., Gelvin, S., & Cattolico, R. A. (1982). Extranuclear DNA of a marine chromophytic alga: restriction enzyme analysis. Plant Physiology 69, 1189-1195. 1982pdf


Aldrich, J. K., & Cattolico, R. A. (1981). Isolation and characterizaton of chloroplast DNA from the marine chromophyte Olisthodiscus luteus: Electron microscopic visualization of isomeric molecular forms. Plant Physiology 68, 641-647. Link

Barlow, S. B., & Cattolico, R. A. (1981). Mitosis and cytokinesis in the Pracinophyceae I: Mantoniella squamata (Manton and Parke) Desikachary. American Journal of Botany 68, 606-615. Link

Ersland, D. R., Aldrich, J. K., & Cattolico, R. A. (1981). Kinetic complexity, homogeneity and copy number of chloroplast DNA from the marine alga Olisthodiscus luteus. Plant Physiology 68, 1468-1473. Link

Ersland, D. R., & Cattolico, R. A. (1981). Nuclear deoxyribonucleic acid characterization of the marine chromophyte Olisthodiscus luteus. Biochemistry 20, 6886-93. Link


Barlow, S. B., & Cattolico, R. A. (1980). Fine structure of the scale-covered green flagellate Mantoniella squamata (Manton and Parke) Desikachary. British Phycological Journal 15, 321-333. Link


Cattolico, R. A. (1978). Variation in plastid number: effect on chloroplast and nuclear DNA complement in the unicellular alga Olisthodiscus luteus. Plant Physiology 62, 558-562. 1978pdf

Cattolico, R. A. (1978). Analysis of chemical components: nucleic acids. In Handbook of Phycological Methods (Hellebust, J.A., and Craigie, J.S., eds.), pp. 81-90. Cambridge University Press, London. Link

Cattolico, R. A. (1978). Physiological and biochemical processes. In Handbook of Phycological Methods (Hellebust, J.A., and Craigie, J.S., eds.), pp. 353-362. Cambridge University Press, London. Link

McIntosh, L., & Cattolico, R. A. (1978). Preservation of algal and higher plant ribosomal RNA integrity during extraction and electrophoretic quantitation. Anal Biochem 91, 600-12. Link


Cattolico, R. A., Boothroyd, J. C., & Gibbs, S. P. (1976). Synchronous growth and plastid replication in the naturally wall-less alga Olisthodiscus luteus. Plant Physiology 57, 497-503. 1976pdf


Cattolico, R. A., & Gibbs, S. P. (1975). Rapid filter method for the microfluorometric analysis of DNA. Anal Biochem 69, 572-82. Link

Cattolico, R. A., & Jones, R. F. (1975). An improved technique for the preparative electrophoresis and electroelution of high molecular weight ribosomal RNA. Anal Biochem 66, 35-46. Link


Cattolico, R. A., Senner, J. W., & Jones, R. F. (1973). Changes in cytoplasmic and chloroplast ribosomal ribonucleic acid during the cell cycle of Chlamydomonas reinhardtii. Arch Biochem Biophys 156, 58-65. Link


Cattolico, R. A., & Jones, R. F. (1972). Isolation of stable ribosomal RNA from whole cells of Chlamydomonas reinhardtii. Biochim Biophys Acta 269, 259-64. Link