Cattolico Laboratory

Evolution, physiology, and molecular biology of the algae



Wee, J.L., Millie, D.F., Nguyen, N.K., Patterson, J., Cattolico, R.A., John, D.E., Paul, J.H. (2016). Growth and biochemical responses of Skeletonema costatum to petroleum contamination. Journal of Applied Phycology, First Online.

Unkefer, C.J., Sayre, R.T., Magnuson, J.K., Anderson, D.B., Baxter, I., Blaby, I.K., Brown, J.K., Carleton, M., Cattolico, R.A., et al. (2016). Review of the algal biology program within the National Alliance for Advanced Biofuels and Bioproducts. Algal Research, In press. Link

Hunsperger, H.M., Ford, C.J., Miller, J.S., Cattolico, R.A. (2016). Differential Regulation of
Duplicate Light-Dependent Protochlorophyllide Oxidoreductases in the Diatom Phaeodactylum tricornutum. PLoS ONE 11(7): e0158614. Link


Hovde, B.T., Deodato, C.R., Hunsperger, H.M., Ryken, S.A., Yost, W., Jha, R.K., Patterson, J., Monnat, R.J., Barlow, S.B., Starkenburg, S.R., Cattolico, R.A. (2015). Genome sequence and transcriptome analyses of Chrysochromulina tobin: Metabolic tools for enhanced algal fitness in the prominent order Prymnesiales (Haptophyceae). PLoS Genetics 11(9): e1005469. Link

Hunsperger, H.M., Randhawa, T., & Cattolico, R.A. (2015). Extensive horizontal gene transfer, duplication, and loss of chlorophyll synthesis genes in the algae. BMC Evolutionary Biology 15: 16. Link


Hovde, B.T., Starkenburg, S.R., Hunsperger, H.M., Mercer, L.D., Deodato, C.R., Jha, R.K., Chertkov, O., Monnat, R.J., & Cattolico, R.A. (2014). The mitochondrial and chloroplast genomes of the haptophyte Chrysochromulina tobin contain unique repeat structures and gene profiles. BMC Genomics 15: 604. Link

Keeling, P.J., Burki, F., Wilcox, H.M., Allam, B., Allen, E.E., Amaral-Zettler, L.A., Armbrust, E.V., Archibald, J.M., Bharti, A.K., Bell, C.J., Beszteri, B., Bidle, K.D., Cameron, C.T., Campbell, L., Caron, D.A., Cattolico, R.A., et al. (2014). The Marine Microbial Eukaryote Transcriptome Sequencing Project (MMETSP): Illuminating the functional diversity of eukaryotic life in the oceans through transcriptome sequencing. PLoS Biology 12(6): e1001889. Link

Starkenburg, S., Kwon, K., Jha, R., McKay, C., Jacobs, M., Chertkov, O., Twary, S., Rocap, G., & Cattolico, R.A. (2014). A pangenomic analysis of the Nannochloropsis organellar genomes reveals novel genetic variations in key metabolic genes. BMC Genomics 15: 212. Link


Tobin, L., Grunbaum, D., Patterson, J., & Cattolico, R.A. (2013). Behavioral and physiological changes during benthic-pelagic transition in the harmful alga, Heterosigma akashiwo: Potential for rapid bloom formation. PLoS ONE 8(10): e76663. Link

Bigelow, N., Barker, J., Ryken, S., Patterson, J., Hardin, W., Barlow, S., Deodato, C., & Cattolico, R.A. (2013). Chrysochromulina sp.: A proposed lipid standard for the algal biofuel industry and its application to diverse taxa for screening lipid content. Algal Research 2(4): 385-393. 2013


Park, B.S., Baek, S.H., Ki, J-S., Cattolico, R.A., & Han, M-S. (2012). Assessment of EvaGreen-based quantitative real-time PCR assay for enumeration of the microalgae Heterosigma and Chattonella (Raphidophyceae). Journal of Applied Phycology 24(6): 1555-1567. Link

Barker, J.P., Cattolico, R.A., & Gatza, E. (2012). Multiparametric analysis of microalgae for biofuels using flow cytometry. BD Biosciences Technical White Paper. Link


Bigelow, N.W., Hardin, W.R., Barker, J.P., Ryken, S.A., MacRae, A.C., & Cattolico, R.A. (2011). A comprehensive GC-MS Sub-microscale assay for fatty acids and its applications. JAOCS, Journal of the American Oil Chemists’ Society 88(9): 1329-1338. 2011pdf

Tobin, E.D., Grünbaum, D., & Cattolico, R.A. (2011). Pelagic-benthic transition of the harmful alga, Heterosigma akashiwo: Changes in swimming and implications for benthic cell distributions. Harmful Algae 10(6): 619-628. Link


Cooper, M. S., Hardin, W. R., Petersen, T. W., Cattolico, R. A. (2010). Visualizing green oil in live algal cells. Journal of Bioscience and Bioengineering, v109 n2 (201002): 198-201. Link

Karol, K., Jacobs, M., Zhou, Z., Sims, E., Gillett, W., & Cattolico R.A. (2010). Organellar genome evolution: comparative analysis of complete mitochondrial and chloroplast genome sequences from geographically distinct strains of Heterosigma akashiwo. In J. Wee, P. Siver, and A-M Lott (Eds.), Chrysophytes : from fossil perspectives to molecular characterizations; proceedings of the Seventh International Chrysophyte Symposium Connecticut College, New London, Connecticut, U.S.A., June 22 – 27, 2008 (pp. 261-282). Stuttgart, Germany: Nova Hedwigia. Link

Ong, H.C., Wilhelm, S.W., Gobler, C.J., Bullerjahn, G., Jacobs, M.A., McKay, J., Sims, E.H., Gillett, W.G., Zhou, Y., Haugen, E., Rocap, G., & Cattolico, R.A. (2010). Analyses of the complete chloroplast genome sequences of two members of the pelagophyceae: Aureococcus anophagefferens CCMP1984 and Aureoumbra lagunensis CCMP1507. Journal of Phycology 46(3): 602-615. Link


Lakeman, M.B., von Dassow, P. & Cattolico, R. A. (2009). The strain concept in phytoplankton ecology. Harmful Algae 8(5): 746-758. 2009pdf


Cattolico, R.A., Jacobs, M.A., Zhou, Y., Chang, J., Duplessis, M., Lybrand, T., McKay, J., Ong, H.C., Sims, E., & Rocap, G. (2008). Chloroplast genome sequencing analysis of Heterosigma akashiwo CCMP452 (West Atlantic) and NIES293 (West Pacific) strains. BMC Genomics 9: 211. Link


Duplessis, M. R., Karol, K. G., Adman, E. T., Choi, L. Y. S., Jacobs, M. A., & Cattolico, R. A. (2007). Chloroplast His-to-Asp signal transduction: a potential mechanism for plastid gene regulation in Heterosigma akashiwo (Raphidophyceae). BMC Evolutionary Biology 7, 70. Link

Lakeman, M. B., & Cattolico, R. A. (2007). Cryptic diversity in phytoplankton cultures is revealed using a simple plating technique. J. Phycol. 43, 662-774. Link


Bearon, R. N., Grunbaum, D., & Cattolico, R. A. (2006). Effects of salinity structure on swimming behavior and harmful algal bloom formation in Heterosigma akashiwo, a toxic raphidophyte. Marine Ecology Progress Series 306, 153-163. 2006pdf


Bearon, R. N., Grunbaum, D., & Cattolico, R. A. (2004). Relating cell-level swimming behaviors to vertical population distributions in Heterosigma akashiwo (Raphidophyceae), a harmful alga. Limnology and Oceanography 49, 607-613. 2004pdf


Han, M-S., Kim, Y-P., & Cattolico, R.A. (2002). Heterosigma akashiwo (Raphidophyceae) resting cell formation in batch culture: Strain identity versus physiological response. Journal of Phycology 38(2): 304-317. Link


Jacobs, M.A. & Cattolico, R.A. (2001). Signal transduction in chromophytic algae: A hypothesis. In: Siver, P.A & J.L. Wee (eds). Chrysophytes and related organisms: topics and issues, Proceedings of the Fifth International Chrysophyte Symposium. Nova Hedwigia Beiheft 122: 211-229. Dr. E. Nagele, Gebruder Borntraeger Verlagsbuchhandlung, Stuttgart, Germany. Link


Jacobs, M. A., Connell, L., & Cattolico, R. A. (1999). A conserved His-Asp signal response regulator-like gene in Heterosigma akashiwo chloroplasts. Plant Molecular Biology 41, 645-655. Link


Cattolico, R. A., Han, M. S., Connell, L., Welling, K., Hatheway, W., & Waaland, J. R. (1998). Heterosigma carterae: A model system for harmful algal bloom studies. Journal of Phycology 34, 11-12.

Hariharan, T., Johnson, P. J., & Cattolico, R. A. (1998). Purification and characterization of phosphoribulokinase from the marine chromophytic alga Heterosigma carterae. Plant Physiol 117, 321-9. Link

Jacobs, M. A., Connell, L. B., & Cattolico, R. A. (1998). His-Asp signal transduction in chloroplasts of Heterosigma carterae. Journal of Phycology 34, 26.

Valentin, K., Fischer, S., & Cattolico, R. A. (1998). The chloroplast bchI gene encodes a subunit of magnesium chelatase in the marine heterokont alga Heterosigma carterae. European Journal of Phycology 33, 113-120. Link


Connell, L., Welling, K., & Cattolico, R. A. (1997). Algal organic metabolites affect survival of Pacific oysters, Crassostrea gigas, larvae. Journal of Shellfish Research 16, 493-501.

Doran, E., & Cattolico, R. A. (1997). Photoregulation of Chloroplast Gene Transcription in the Chromophytic Alga Heterosigma carterae. Plant Physiol 115, 773-781. Link


Connell, L. & Cattolico, R.A. (1996). Fragile algae: Axenic culture of field-collected samples of Heterosigma carterae. Marine Biology 125(2): 421-426. Link


Hardison, L. K., Boczar, B. A., & Cattolico, R. A. (1995). psbA in the marine chromophyte Heterosigma carterae: evolutionary analysis and comparative structure of the D1 carboxyl terminus. American Journal of Botany 82, 893-902. Link

Mangahas, J. L., Cattolico, R. A., & Reynolds, A. E. (1995). Analysis of Heterosigma carterae (CHROMOPHYTA, RAPHIDOPHYCEAE) chloroplast rpoB gene sequence. Journal of Phycology 31, 808-812. Link


Delaney, T. P., Hardison, L., & Cattolico, R. A. (1994). Evolution of plastid genomes: Inferences from discordant molecular phylogenies. In Chrysophyte Algae: Ecology, Phylogeny and Development (Sandgren, C., Smol, J. & Kristiansen, J., eds.). Cambridge University Press, England. Link

Reynolds, A. E., Chesnick, J. M., Woolford, J., & Cattolico, R. A. (1994). Chloroplast encoded thioredoxin genes in the red algae Porphyra yezoensis and Griffithsia pacifica: evolutionary implications. Plant Mol Biol 25, 13-21. Link


Chesnick, J. M., & Cattolico, R. A. (1993). Isolation of DNA from eukaryotic algae. Methods Enzymol 224, 168-76. Link

Reynolds, A. E., McConaughy, B. L., & Cattolico, R. A. (1993). Chloroplast genes of the marine alga Heterosigma carterae* are transcriptionally regulated during a light/dark cycle. Mol Mar Biol Biotechnol 2(3), 121-128. 1993pdf

Valentin, K., Cattolico, R. A., & Zetsche, K. (1993). Phylogenetic origin of the plastids. In Origins of Plastids: Symbiogenesis, Prochlorophytes and the Origins of Chloroplasts (Lewin, R., ed.), pp. 193-222. Chapman and Hall, New York/London. Link

Wee, J., Chesnick, J., & Cattolico, R. A. (1993). Partial characterization of the chloroplast genome from the chromophytic alga Synura petersenii (Synurophyceae). Journal of Phycology 29, 96-99. Link


Hardison, L. K., Boczar, B. A., Reynolds, A. E., & Cattolico, R. A. (1992). A description of the Rubisco large subunit gene and its transcript in Olisthodiscus luteus. Plant Mol Biol 18, 595-9. Link

Li, N., & Cattolico, R. A. (1992). Ochromonas danica (Chrysophyceae) chloroplast genome organization. Molecular Marine Biology and Biotechnology 1, 165-174.

Reynolds, A. E., McConaughy, B., & Cattolico, R. A. (1992). Marine algal chloroplast genes are transcriptionally regulated during a Diel cycle. Molec Marine Biology and Biotechnology 2, 121-128.

Shivji, M. S., Li, N., & Cattolico, R. A. (1992). Structure and organization of rhodophyte and chromophyte plastid genomes: implications for the ancestry of plastids. Mol Gen Genet 232, 65-73. Link


Boczar, B. A., & Cattolico, R. A. (1991). Characterization of satellite DNA from three marine dinoflagellates (Dinophyceae): Glenodinium sp. and two members of the toxic genus, Protogonyaulax. Plant Physiol 97, 613-618. 1991pdf

Chesnick, J., Kugrens, P., & Cattolico, R. A. (1991). The validity of morphological characteristics in determination of Cryptomonad Phyletics: Mitochondrial DNA assessment. Molec Marine Biology 1, 18-26.

Delaney, T. P., & Cattolico, R. A. (1991). Sequence and secondary structure of chloroplast 16S rRNA from the chromophyte alga Olisthodiscus luteus, as inferred from the gene sequence. Nucleic Acids Res 19, 6328. Link

Li, N., Hedberg, M.F., & Cattolico, R.A. (1991). Chloroplast DNA heterogeneity in Monodus sp. (Eustigmatophyta). Current Genetics 20(1-2): 157-159. Link


Cattolico, R. A., & Loiseaux-de Goer, S. (1990). Analysis of chloroplast evolution and phylogeny: a molecular approach. In The Chromophyte Algae: Problems and Perspectives (Green, J.C., Leadbeater, B.S.C., and Diver, W.L., eds.), Vol. 38, pp. 85-100. Oxford University Press, Oxford. Link

Newman, S., & Cattolico, R. A. (1990). Biochemistry and evolution of Rubisco in algal systems. Photosynthesis Research 26, 69-85.


Boczar, B. A., Delaney, T. P., & Cattolico, R. A. (1989). Gene for the ribulose-1,5-bisphosphate carboxylase small subunit protein of the marine chromophyte Olisthodiscus luteus is similar to that of a chemoautotrophic bacterium. Proc Natl Acad Sci USA 86, 4996-9. 1989pdf

Delaney, T. P., & Cattolico, R. A. (1989). Chloroplast ribosomal DNA organization in the chromophytic alga Olisthodiscus luteus. Curr Genet 15, 221-9. Link

Newman, S., DeRocher, J., & Cattolico, R. A. (1989). Analysis of Chromophytic and Rhodophytic Ribulose-1,5-Bisphosphate Carboxylase Indicates Extensive Structural and Functional Similarities among Evolutionarily Diverse Algae. Plant Physiol 91, 939-946. 1989pdf


Boczar, B.A., Beitler, M.K., Liston, J., Sullivan, J.J., & Cattolico, R.A. (1988). Paralytic shellfish toxins in Protogonyaulax tamarensis and Protogonyaulax catenella in axenic culture. Plant Physiology 88(4): 1285-1290. Link

Newman, S., & Cattolico, R. A. (1988). Synthesis of active Olisthodiscus luteus ribulose 1,5 bisphosphate carboxylase in E. coli. Plant Mol Biol 11, 821-831. Link


Li, N., & Cattolico, R. A. (1987). Chloroplast genome characterization in the red alga Griffithsia pacifica. Molec Gen Genet 209, 343-351. Link

Newman, S., & Cattolico, R. A. (1987). Structural and functional relatedness of chromophytic and rhodophytic RuBP carboxylase enzymes. Prog in Photosyn Res 4, 671-674.

Newman, S., & Cattolico, R. A. (1987). Structural, functional, and evolutionary analysis of ribulose 1,5 bisphosphate carboxylase from the chromophytic alga Olisthodiscus luteus. Plant Physiol 84, 483-490. 1987pdf


Cattolico, R. A. (1986). Chloroplast evolution in algae and land plants. Trends in Ecology and Evolution 1, 64-67. Link

Cattolico, R. A., Aldrich, J. K., Bressler, S., Ensland-Talbot, D., Newman, S., & Reith, M. E. (1986). Chloroplast DNA in the Chrysophyceae: copy number, packaging, and gene expression in Olisthodiscus luteus. In Chrysophytes: Aspects and Problems (Anderson, J. K. a. R., ed.), pp. 143-162. Cambridge University Press, England. Link

Reith, M. E., & Cattolico, R. A. (1986). The inverted repeat of Olisthodiscus luteus ctDNA contains the genes for both subunits of RuBPcase and the 32,000 QB protein: phylogenetic implication. Proc Natl Acad Sci USA 83, 8599-8603.


Cattolico, R. A. (1985). Chloroplast biosystematics: chloroplast DNA as a molecular probe. Biosystems 18, 299-306. Link

Reith, M. E., & Cattolico, R. A. (1985). In vitro chloroplast protein synthesis by the chromophytic alga Olisthodiscus luteus. Biochemistry 24, 2550-6. Link

Reith, M. E., & Cattolico, R. A. (1985). In vivo chloroplast protein synthesis by the chromophytic alga Olisthodiscus luteus. Biochemistry 24, 2556-2561.Link

Reith, M. E., & Cattolico, R. A. (1985). Cell cycle analysis of polypeptides synthesized by the chromophytic alga Olisthodiscus luteus. Plant Physiol 79, 231-236. 1985pdf


Aldrich, J. K., Gelvin, S., & Cattolico, R. A. (1982). Extranuclear DNA of a marine chromophytic alga: restriction enzyme analysis. Plant Physiology 69, 1189-1195. 1982pdf


Aldrich, J. K., & Cattolico, R. A. (1981). Isolation and characterizaton of chloroplast DNA from the marine chromophyte Olisthodiscus luteus: Electron microscopic visualization of isomeric molecular forms. Plant Physiology 68, 641-647. Link

Barlow, S. B., & Cattolico, R. A. (1981). Mitosis and cytokinesis in the Pracinophyceae I: Mantoniella squamata (Manton and Parke) Desikachary. American Journal of Botany 68, 606-615. Link

Ersland, D. R., Aldrich, J. K., & Cattolico, R. A. (1981). Kinetic complexity, homogeneity and copy number of chloroplast DNA from the marine alga Olisthodiscus luteus. Plant Physiology 68, 1468-1473. Link

Ersland, D. R., & Cattolico, R. A. (1981). Nuclear deoxyribonucleic acid characterization of the marine chromophyte Olisthodiscus luteus. Biochemistry 20, 6886-93. Link


Barlow, S. B., & Cattolico, R. A. (1980). Fine structure of the scale-covered green flagellate Mantoniella squamata (Manton and Parke) Desikachary. British Phycological Journal 15, 321-333. Link


Cattolico, R. A. (1978). Variation in plastid number: effect on chloroplast and nuclear DNA complement in the unicellular alga Olisthodiscus luteus. Plant Physiology 62, 558-562. 1978pdf

Cattolico, R. A. (1978). Analysis of chemical components: nucleic acids. In Handbook of Phycological Methods (Hellebust, J.A., and Craigie, J.S., eds.), pp. 81-90. Cambridge University Press, London. Link

Cattolico, R. A. (1978). Physiological and biochemical processes. In Handbook of Phycological Methods (Hellebust, J.A., and Craigie, J.S., eds.), pp. 353-362. Cambridge University Press, London. Link

McIntosh, L., & Cattolico, R. A. (1978). Preservation of algal and higher plant ribosomal RNA integrity during extraction and electrophoretic quantitation. Anal Biochem 91, 600-12. Link


Cattolico, R. A., Boothroyd, J. C., & Gibbs, S. P. (1976). Synchronous growth and plastid replication in the naturally wall-less alga Olisthodiscus luteus. Plant Physiology 57, 497-503. 1976pdf


Cattolico, R. A., & Gibbs, S. P. (1975). Rapid filter method for the microfluorometric analysis of DNA. Anal Biochem 69, 572-82. Link

Cattolico, R. A., & Jones, R. F. (1975). An improved technique for the preparative electrophoresis and electroelution of high molecular weight ribosomal RNA. Anal Biochem 66, 35-46. Link


Cattolico, R. A., Senner, J. W., & Jones, R. F. (1973). Changes in cytoplasmic and chloroplast ribosomal ribonucleic acid during the cell cycle of Chlamydomonas reinhardtii. Arch Biochem Biophys 156, 58-65. Link


Cattolico, R. A., & Jones, R. F. (1972). Isolation of stable ribosomal RNA from whole cells of Chlamydomonas reinhardtii. Biochim Biophys Acta 269, 259-64. Link