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Pharmacokinetics of fluoride varnish in preschool children

PI: Peter Milgrom, D.D.S., Professor, Dental Public Health Sciences, School of Dentistry, University of Washington.

Fluoride varnish is an important tool in the prevention of dental caries. The varnish provides a medium by which relatively high concentrations of fluoride adhere to the tooth enamel for extended periods of time. A previous study found peak serum fluoride level of between 60 and 120 ng F/ml in 4 school-age children two hours after multiple applications of 0.11-15 ml varnish (5.0-5.2 mg F). These values are far below levels considered toxic. Nevertheless, the varnish pharmacokinetics have never been studied in preschool children although it has applications in this age group.

The purpose of this research is to describe the pharmacokinetic profile of sodium fluoride varnish when applied to the teeth of healthy children between one to five years old. Subjects continue to be enrolled. Investigators are six months from breaking the blind and analyzing the data. Descriptive statistics are being used to summarize the observed peak concentration values (Cmax) and observed times of the peak concentrations (Tmax).

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