NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genetic Research Centers (GRCs) (U01)

The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) was established in July, 2002 for the purpose of identifying genes predisposing to IBD.  Since its establishment, the IBDGC, in collaboration with the International IBD Genetics Consortium, has identified about 200 such susceptibility loci.  However, most of these loci include multiple genes, and for the great majority of the loci, specific causal genes and alleles have not yet been identified.  The mechanisms by which the most of the causative genes influence IBD pathophysiology also remain unknown.  The purpose of this FOA is to renew the IBDGC to identify risk-conferring and protective variants of causal genes for IBD, and to elucidate the mechanisms by which these variants influence the pathophysiology of IBD.  The GRCs will serve as sites of enrollment of IBD patients, relatives, and healthy controls for these studies, and for laboratory-based studies on biological samples taken from these subjects.  The Program Directors/Principal Investigators of the GRCs will serve as members of the Steering Committee of the IBDGC, which will be responsible for all of the IBDGC's operational decisions, which will be binding upon all of the IBDGC's members.

Application Instructions

Please submit:

• a one-page letter of intent with a description of proposed aims and approach
• Biosketch or CV of the PI
• A letter of support from the Dean or Chair. This letter of support signifies that the Dean or Chair have ensured that the nominee and application are likely to be of sufficient quality to be competitive nationally

to research@uw.edu by 5:00 PM Thursday October 20, 2016. Proposals are due to the sponsor 12/14/16, so you will need to have your materials in to the Office of Sponsored Programs by 12/6/16 for processing, if given the go ahead by the Proposal Review Committee.