All of Us Research Program Genome Centers (OT2)

The purpose of this funding announcement (FA) is to solicit applications for Genome Centers to generate and process genomic data as part of the All of Us Research Program. The All of Us Research Program seeks to create one of the world’s largest and most comprehensive precision medicine research platforms with a data resource containing multi-layered data on one million or more participants. The All of Us Genome Centers will generate both genotype and whole genome sequence data from biospecimens from this cohort. These Centers also will operate an analysis workflow resulting in high-confidence calling of all variant types (single nucleotide variants, small insertions/deletions, larger structural variants including copy number variations) and establish a robust pipeline to securely transfer data to the All of Us Data and Research Center.

Genome Centers awarded under this FA will be responsible for 1) developing the capacity and rigor necessary to achieve unprecedented scale of genomic data generation, up to 200,000 assays per year, 2) generating high-quality genotype and genome sequence data, with state-of-the-science variant calling, as a crucial data element for the All of Us data resource, 3) providing limited variant pathogenicity interpretation as an initial step in workflows for return of information to participants in the program, 4) deploying a fully compliant clinical validation workflow including generation of a clinical report for certain pathogenic variants defined by the program, 5) innovating for the advancement of technologies and approaches for population-scale genome analysis, 6) establishing strong collaborative relationships with other awardees supporting the  All of Us genomics platform, and 7) contributing to strategic planning for the program as members of  the  All of Us consortium.

Application Instructions

Please submit:

1. a one-page letter of intent with a description of proposed aims and approach
2. Biosketch or CV of the PI

to research@uw.edu by 5:00 PM Wednesday May 30, 2018. Full proposals are due to the sponsor 7/21/18, so you will need to have your materials in to the Office of Sponsored Programs by 7/12/18 for processing, if given the go ahead by the Proposal Review Committee.