Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required)

The overall goal of this Notice of Funding Opportunity (NOFO) is to improve the treatment of adult Glioblastoma Multiforme (GBM) by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them in the clinic. To implement this initiative, multi-institutional teams are invited to participate in the Glioblastoma Therapeutics Network (GTN). Each GTN team is expected to drive therapeutic agent(s) from late pre-clinical development, through IND studies, into pilot clinical studies in humans. Successful early-stage trials of these new drugs would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms.

The purpose of this opportunity is to build upon momentum established in the GTN's initial phase by establishing a network (GTN) of highly collaborative U19 teams, each team capable of driving therapeutic agent(s) from pre-clinical development, through IND studies, into pilot clinical studies in humans. Agents proposed for development in the GTN should not have been tested previously in GBM patients. Appropriate development candidates include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following relevant preclinical studies. As developing drugs from the discovery phase is a long, expensive process that often encounters obstacles and failures, this NOFO focuses on agents in the Preclinical Development stage. A unique aspect of the GTN will be the ability of members to leverage models and methodologies for cross-validation of promising agents across the network.

Application Instructions

Please submit as one combined pdf labeled with PI’s Lastname, Firstname:

1. A one‐page letter of intent with a description of proposed aims and approach.
2. If the final application requires a statement of broader impacts, please summarize your plans to address the specific requirements on an additional page.
3. CV (not biosketch) of the PI including past grant funding.

to limitedsubs@uw.edu by 5:00 PM Monday, September 14, 2026. Late pre-proposals will not be considered. Proposals are due to the sponsor 10/1/2026 so you will need to have your materials in to the Office of Sponsored Programs by 9/22/2026 if given the go‐ahead by the Limited Submissions review committee.