Immune Tolerance Network (UM1 Clinical Trial Required)

This notice of funding opportunity (NOFO) supports applications to continue the Immune Tolerance Network (ITN). The primary objective of the Network is to develop tolerogenic therapies for immune-mediated disorders. The three main clinical areas of work are: 1) Allergic diseases and asthma; 2) Autoimmune diseases; and 3) Immune-mediated consequences of transplantation. The core functions of the ITN include designing, conducting, and sharing the results of clinical trials and performing integrated mechanistic studies.

The goal of the NOFO is to assist public and private nonprofit institutions and individuals to establish, expand and improve biomedical research and research training in infectious diseases and related areas; to conduct developmental research, to produce and test research materials. To assist public, private and commercial institutions to conduct developmental research, to produce and test research materials, to provide research services as required by the agency for programs in infectious diseases, and controlling disease caused by infectious or parasitic agents, allergic and immunologic diseases and related areas. Projects range from studies of microbial physiology and antigenic structure to collaborative trials of experimental drugs and vaccines, mechanisms of resistance to antibiotics as well as research dealing with epidemiological observations in hospitalized patients or community populations and progress in allergic and immunologic diseases. Because of this dual focus, the program encompasses both basic research and clinical research.

Funding available is up to $23 million per year in direct costs over 7 years.

Application Instructions

Please submit as one combined pdf labeled with PI’s Lastname, Firstname:

1. A one‐page letter of intent with a description of proposed aims and approach.
2. If the final application requires a statement of broader impacts, please summarize your plans to address the specific requirements on an additional page.
3. CV (not biosketch) of the PI including past grant funding.

to limitedsubs@uw.edu by 5:00 PM Wednesday, December 16, 2026. Late pre-proposals will not be considered. Proposals are due to the sponsor 1/29/2027 so you will need to have your materials in to the Office of Sponsored Programs by 1/20/2027 if given the go‐ahead by the Limited Submissions review committee.