2001 Publications

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• Papers
• Books and book chapters
• Abstracts

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Papers

• Audoly S, Bellu G, D'Angio L, Saccomani MP, Cobelli C. Global identifiability of nonlinear models of biological systems. IEEE Trans Biomed Eng. 2001 Jan;48(1):55-65. [C]
• Barrett PH, Watts GF. HDL kinetics, fish oils and diabetes. Atherosclerosis. 2001 Nov;159(1):243-4. [C]
• Bell, B.M. Approximating the marginal likelihood estimate for models with random parameters. Applied Mathematics and Computation 119: 57-75, 2001. [T]
• Bellazzi R, Nucci G, Cobelli C. The subcutaneous route to insulin-dependent diabetes therapy. IEEE Eng Med Biol Mag. 2001 Jan-Feb;20(1):54-64. Review. No abstract available. [C]
• Bertoldo A, Peltoniemi P, Oikonen V, Knuuti J, Nuutila P, Cobelli C. Kinetic modeling of [(18)F]FDG in skeletal muscle by PET: a four-compartment five-rate-constant model. Am J Physiol Endocrinol Metab. 2001 Sep;281(3):E524-36. [C]
• Breda E, Cobelli C. Insulin secretion rate during glucose stimuli: alternative analyses of C-peptide data. Ann Biomed Eng. 2001 Aug;29(8):692-700. [C]
• Breda E, Cavaghan MK, Toffolo G, Polonsky KS, Cobelli C. Oral glucose tolerance test minimal model indexes of beta-cell function and insulin sensitivity. Diabetes. 2001 Jan;50(1):150-8. [C]
• Carr M A, Hokanson JE, Zambon A, Deeb SS, Barrett PHR, Purnell JQ, Brunzell JD. Intraabdominal fat accounts for a portion of the gender differences in hepatic lipase activity and LDL/HDL heterogeneity. J Clin Endo Metab. 2001; 86: 2831-2837. [C]
• Dane-Stewart C, Watts G, Mamo JCL, Dimmitt SB, Barrett PHR, Redgrave TG. Elevated apolipoprotein B-48 and remnant-like particlecholesterol in heterozygous familial hypercholesterolaemia. Eur J Clin Invest 2001; 31: 113-117. [C]
• Huggins KW, Colvin PL, Burleson ER, Kelley K, Sawyer JK, Barrett PH, Rudel LL, Parks JS. Dietary n-3 polyunsaturated fat increases the fractional catabolic rate of medium-sized HDL particles in African green monkeys. J Lipid Res. 2001 Sep;42(9):1457-66. [C]
• Jauregizar N, Calvo R, Suarez E, Quintana A, Raczka E, Lukas JC. Altered disposition and effect of lerisetron in rats with elevated alpha 1-acid glycoprotein levels. Pharm Res. 2001 Jun;18(6):838-45.
• Kelley DE, Price JC, Cobelli C. Assessing skeletal muscle glucose metabolism with positron emission tomography. IUBMB Life. 2001 Dec;52(6):279-84. Review. [C]
• Konrad T, Golling M, Vicini P, Toffolo G, Wittman M, Mahon A, Klar E, Cobelli C, Usadel K. Insulin sensitivity and beta-cell secretion after liver transplantation in patients with acute liver failure. Transplant Proc. 2001 Jun;33(4):2576-9. [C]
• Konrad T, Markus B, Allers C, Vicini P, Toffolo G, Lakos C, Viehmann K, Hanisch E, Encke A, Cobelli C, Usadel KH. Impact of cyclosporine and low-dose steroid therapy on insulin sensitivity and beta-cell function in patients with long-term liver grafts. Transpl Int. 2001;14(1):6-11. [C]
• Olin KL, Potter-Perigo S, Barrett PHR, Wight TN, Chait A. Biglycan, a vascular proteoglycans, binds differently to high density lipoprotein (HDL)2 and HDL3: Role of apolipoprotein E. Arterioscler Thromb Vasc Biol. 2001; 21: 129-135. [C]
• Pillonetto G, Sparacino G, Cobelli C. Reconstructing insulin secretion rate after a glucose stimulus by an improved stochastic deconvolution method. IEEE Trans Biomed Eng. 2001 Nov;48(11):1352-4. [C]
• Rashid S, Uffelman K, Barrett P, Vicini P, Adeli K, Lewis G. Triglyceride enrichment of HDL does not alter HDL-selective cholesteryl ester clearance in rabbits. J Lipid Res. 2001 Feb;42(2):265-71. [C]
• Redgrave TG, Watts GF, Martins IJ, Barrett PHR, Mamo JCL, Dimmitt SB, Marais AD. Chylomicron remnant metabolism studied with a new breath test in familial dyslipidaemias. J Lipid Res. 2001; 42: 710-715. [C]
• Spilker ME, Vicini P. An evaluation of extended vs weighted least squares for parameter estimation in physiological modeling. J Biomed Inform. 2001 Oct;34(5):348-64. [T]
• Sunehag AL, Treuth MS, Toffolo G, Butte NF, Cobelli C, Bier DM, Haymond MW. Glucose production, gluconeogenesis, and insulin sensitivity in children and adolescents: an evaluation of their reproducibility. Pediatr Res. 2001 Jul;50(1):115-23. [C]
• Toffolo G, Breda E, Cavaghan MK, Ehrmann DA, Polonsky KS, Cobelli C. Quantitative indexes of beta-cell function during graded up&down glucose infusion from C-peptide minimal models. Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E2-10.
• Vicini P, Cobelli C. The iterative two-stage population approach to IVGTT minimal modeling: improved precision with reduced sampling. Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E179-86. [T]
• Watts GF, Barrett PHR. Dietary plant sterols, plasma cholesterol and lipoprotein metabolism. Aus J Cardiovasc Med. 2001 2: 26-28. [C]
• Watts GF, Chan DC, Barrett PH, Martins IJ, Redgrave TG. Preliminary experience with a new stable isotope breath test for chylomicron remnant metabolism: a study in central obesity. Clin Sci (Lond). 2001 Dec;101(6):683-90. [C]

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Books and book chapters

• Carson, C., and C. Cobelli, Modeling Methodology for Physiology and Medicine, Academic Press (Biomedical Engineering Series), 2001. Modeling Methodology for Physiology and Medicine offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modelling methodology that is widely applicable to physiology and medicine. The book opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The methodology presented in this book is applied to a range of real-world problems including circulation, respiration, metabolism, and endocrinology. Readers are in need of this latest methodology to keep up-to-date in their field.
• Cobelli, C., D. M. Foster, G. Toffolo. Tracer Kinetics in Biomedical Research: From Data to Model. Plenum Publishing Corp., 2001. This book/CD-ROM package gives mathematical and statistical information necessary to design tracer kinetic studies, to use noncompartmental methodologies, and to develop multicompartmental models to interpret data. Starts with a review of fundamentals of radioactive and stable isotope tracer kinetics, then describes the noncompartmental and multicompartmental modeling methodologies for studying systems in the steady state. Focus is on understanding basic assumptions inherent in the methodologies and the underlying mathematics and statistics, on discussing how to assess models, and on designing kinetic studies. Includes extensive material on parameter estimation. The CD-ROM contains examples.
• Foster DM. Noncompartmental vs. compartmental approaches to pharmacokinetic analysis. In: Principles of Clinical Pharmacology, AJ Atkinson et al., Eds., Academic Press, 2001, pp. 75-92.

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Abstracts

• Pierce, CH, YL Chen, RL Dills, MS Morgan, DA Kalman. Toluene Metabolites as Biological Indicators of Exposure, Society for Risk Analysis, Seattle, 2001.
• Pierce, CH., Yi Li Chen, William Hurtle, Russell L. Dills and Michael S. Morgan. Exponential Modeling, Washout Curve Reconstruction, and Estimation of Half-Life of Toluene, Society for Risk Analysis, Seattle, 2001
• Kushmerick MJ, Vicini P, Conley KE, Shankland E, Jubrias S. Integrated kinetic model of energetics in exercising muscle. Biophysical Journal 80 (1): 333, Part 2, 2001.
• Vicini P. Integrated system models to understand disease status, progression and therapy: case studies. PAGE (Population Approach Group in Europe) Tenth Meeting, 7-8 June 2001, Basel, Switzerland.
• Dodds MG, A. Hooker, Bell BM and Vicini P. Realistic optimal experimental design incorporating population variability. Annals of Biomedical Engineering 29: Supplement 1, S-17: P.2.24, 2001.
• Hooker A, M. Foracchia, Dodds MG and Vicini P. Optimal design in large scale clinical trials. Annals of Biomedical Engineering 29: Supplement 1, S-9: 2.3.6, 2001.
• Sparacino G, D. M. Shames, Vicini P, J. C. King, and C. Cobelli. Domain of validity of the DITR method for measuring fractional zinc absorption: theoretical justification. APStracts 8:0278E, 2001.
• Gibbs MA, J. Fisher, D. D. Shen, Vicini P, S. Wrighton, K. E. Thummel. Pharmacokinetic Model for Midazolam Metabolism and Distribution in Caco-2 Cell Monolayer. PharmSci 3:3 (Supplement), 1476, 2001.
• Yao AA, J. Agosti, M. Rogge, Vicini P. Pharmacokinetics of Soluble Recombinant Human Interleukin-4 Receptors (IL4-R). PharmSci 3:3 (Supplement), 133, 2001.
• Yao AA, M. Rogge, J. Agosti, Vicini P. Population Pharmacokinetics of Nebulized Soluble Recombinant Human Interleukin-4 Receptors (IL4-R) (Nuvance) in Adult patients with Moderate Asthma. PharmSci 3:3 (Supplement), 1808, 2001.
• Yao AA, J.T. Slattery, G.B. McDonald, and Vicini P. Population pharmacokinetics of cyclophosphamide and its metabolites in hematopoietic stem-cell transplantation patients. PAGE (Population Approach Group in Europe) Eleventh Meeting, 6-7 June 2001, Paris, France.

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