2003 Publications

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• Papers
• Books and book chapters
• Abstracts

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Papers

• Agerso H, Vicini P. Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative. Eur J Pharm Sci. 2003 Jun;19(2-3):141-50.[C]
• Avogaro A, Toffolo G, Kiwanuka E, De Kreutzenberg SV, Tessari P, Cobelli C. L-arginine-nitric oxide kinetics in normal and type 2 diabetic subjects: a stable-labelled (15)n arginine approach. Diabetes 2003 52(3):795-802.
• Barrett PH, Watts GF. Kinetic studies of lipoprotein metabolism in the metabolic syndrome including effects of nutritional interventions. Curr Opin Lipidol. 2003 Feb;14(1):61-8. [C]
• Basu R, Breda E, Oberg AL, Powell CC, Dalla Man C, Basu A, Vittone JL, Klee GG, Arora P, Jensen MD, Toffolo G, Cobelli C, Rizza RA. Mechanisms of the Age-Associated Deterioration in Glucose Tolerance: Contribution of Alterations in Insulin Secretion, Action, and Clearance. Diabetes. 2003 Jul;52(7):1738-1748. [C]
• Basu R, Di Camillo B, Toffolo G, Basu A, Shah P, Vella A, Rizza R, Cobelli C. Use of a novel triple-tracer approach to assess postprandial glucose metabolism. Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E55-69. [C]
• Bies RR, Bigos K, Pollock BG. Gender differences in the pharmacokinetics and pharmcodynamics of antidepressants. J.Gend Spec Med. 2003;6:3:12-20.
• Borradaile NM, de Drue LE, Barrett PHR, Behrsin CD, Huff MW. Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, Naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation. Biochem 2003; 42: 1283-1291.
• Callegari T, Caumo A, Cobelli C. Bayesian two-compartment and classic single-compartment minimal models: comparison on insulin modified IVGTT and effect of experiment reduction. IEEE Trans Biomed Eng. 2003 Dec;50(12):1301-1309
• Chan DC, Watts GF, Barrett PH. Comparison of intraperitoneal and posterior subcutaneous abdominal adipose tissue compartments as predictors of VLDL apolipoprotein B-100 kinetics in overweight/obese men. Diabetes Obes Metab. 2003 May;5(3):202-6. [C]
• Chan DC, Watts GF, Barrett PHR, Burke V. Waist circumference, waist-to-hip ratio and body mass index as predictors of adipose tissue compartments in men. Q J Med 2003; 96: 441-447.
• Chan DC, Watts GF, Barrett PHR, O'Neill FH, Redgrave TG, Thompson GR. Relationships between cholesterol homoeostasis and triglyceride-rich lipoprotein remnant metabolism in the metabolic syndrome. Clinical Science 2003; 104: 383-388.
• Chan DC, Watts GF, Barrett PHR, O' Neill FH, Thompson GR. Plasma markers of cholesterol homeostasis and apolipoprotein B-100 kinetics in the metabolic syndrome. Obesity Res 2003; 11: 591-596.
• Chan DC, Watts GF, Mori TA, Barrett PH, Redgrave TG, Beilin LJ. Randomized controlled trial of the effect of n-3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity. Am J Clin Nutr. 2003 Feb;77(2):300-7. [C]
• Ching HL, Watts GF, Dhaliwal SS, Barrett PHR, Stuckey BGA. Vascular function of the forearm microcirculation in post-menopausal women with type 2 diabetes: potential of hormonal replacement therapy? Climacteric 2003; 6: 31-37.
• Dane-Stewart CA, Watts GF, Barrett PHR, Stuckey BG, Mamo JC, Martins IJ, Redgrave TG. Chylomicron remnant metabolism studied with a new breath test in postmenopausal women with and without type 2 diabetes mellitus. Clin Endocrinol 2003; 58: 415-420.
• Davis TME, Syed D, Ilett KF, Barrett PHR. Toxicity related to chloroquine treatment of resistant Vivax Malaria. Ann Pharmacother 2003; 37:526-529.
• Donangelo CM, Woodhouse LR, King SM, Toffolo G, Shames DM, Viteri FE, Cheng Z, Welch RM, King JC. Iron and zinc absorption from two bean (Phaseolus vulgaris L.) genotypes in young women. Agric Food Chem. 2003; 13;51(17):5137-43.
• Hegele RA, Zinman B, Hanley AJG, Harris SB, Barrett PHR, Cao H. Genes, environment and Oji-Cree type 2 diabetes. Clin Biochem 2003; 36: 163-170.
• Hooker AC, Foracchia M, Dodds MG, Vicini P. An evaluation of population D-optimal designs via pharmacokinetic simulations. Ann Biomed Eng . 2003 Jan;31(1):98-111. [T]
• James AP, Watts GF, Barrett PH, Smith D, Pal S, Chan DC, Mamo JC. Effect of weight loss on postprandial lipemia and low-density lipoprotein receptor binding in overweight men. Metabolism. 2003 Feb;52(2):136-41. [C]
• Kerwin W, Hooker A, Spilker M, Vicini P, Ferguson M, Hatsukami T, Yuan C. Quantitative magnetic resonance imaging analysis of neovasculature volume in carotid atherosclerotic plaque. Circulation. 2003 Feb 18;107(6):851-6. [C]
• Nolin TD, Gastonguay MR, Bies RR, Matzke GR, RF Frye. Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: implication for cytochrome P450 2E1 pharmacogenetic studies. Clin Pharm Ther. 2003 Dec;74(6): 555-568.
• Osterberg O, Erichsen L, Ingwersen SH, Plum A, Poulsen HE, Vicini P. Pharmacokinetic and pharmacodynamic properties of insulin aspart and human insulin. J Pharmacokinet Pharmacodyn. 2003 Jun;30(3):221-35.
• Parhofer KD, Laubach E, Barrett PHR. The effect of atorvastatin on postprandial lipoprotein metabolism in hypertriglyceridemic patients. J Lipid Res 2003; 44: 1192-1198.
• Pillonetto G, Sparacino G, Cobelli C. Numerical non-identifiability regions of the minimal model of glucose kinetics: superiority of Bayesian estimation. Math Biosci. 2003 Jul;184(1):53-67. [T]
• Prinsen BH, Romijn JA, Bisschop PH, de Barse MM, Barrett PH, Ackermans M, Berger R, Rabelink TJ, de Sain-van der Velden MG. Endogenous cholesterol synthesis is associated with VLDL-2 apoB-100 production in healthy humans. J Lipid Res. 2003 Jul;44(7):1341-8. [C]
• Qian H, Beard DA, Liang SD. Stoichiometric network theory for nonequilibrium biochemical systems. Eur J Biochem. 2003 Feb;270(3):415-21.
• Sabatier M, Pont F, Arnaud MJ, Turnlund JR. A compartmental model of magnesium metabolism in healthy men based on two stable isotope tracers. Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R656-63. [C]
• Telford DE, Edwards JY, Lipson SM, Sutherland B, Barrett PHR, Burnett JR, Krul ES, Keller BT, Huff MW. Inhibition of the both the apical sodium-dependent bile acid transporter and HMG-CoA reductase: Enhanced clearance of LDL apoB. J Lipid Res 2003; 44: 943-952.
• Toffolo G, Albright R, Joyner M, Dietz N, Cobelli C, Nair KS. Model to assess muscle protein turnover: domain of validity using amino acyl-tRNA vs. surrogate measures of precursor pool. Am J Physiol Endocrinol Metab. 2003; 285(5):E1142-9.
• Toffolo G, Cobelli C. The hot IVGTT two-compartment minimal model: an improved version. Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E317-21. [T]
• Watts GF, Barrett PH, Ji J, Serone AP, Chan DC, Croft KD, Loehrer F, Johnson AG. Differential Regulation of Lipoprotein Kinetics by Atorvastatin and Fenofibrate in Subjects With the Metabolic Syndrome. Diabetes. 2003 Mar;52(3):803-811. [C]
• Watts GF, Chan DC, Barrett PHR, O'Neill FH, Thompson GR. Effect of a statin on hepatic apolipoprotein B-100 secretion and plasma campesterol levels in the metabolic syndrome. Intl J Obesity 2003; 27: 862-865.
• Watts GF, Chan DC, Barrett PH, Susekov AV, Hua J, Song S. Fat compartments and apolipoprotein B-100 kinetics in overweight-obese men. Obes Res. 2003 Jan;11(1):152-9. [C]
• Whitfield AJ, Marais AD, Robertson K, Barrett PHR, van Bockxmeer FM, Burnett JR. Four novel mutations in apoB causing heterozygous and homozygous familial hypobetalipoproteinemia. Human Mutation 2003; 22: 178.
• Williams KV, Bertoldo A, Kinahan P, Cobelli C, Kelley DE. Weight loss-induced plasticity of glucose transport and phosphorylation in the insulin resistance of obesity and type 2 diabetes. Diabetes. 2003 Jul;52(7):1619-26. [C]
• Williams KV, Bertoldo A, Mattioni B, Price JC, Cobelli C, Kelley DE. Glucose transport and phosphorylation in skeletal muscle in obesity: insight from a muscle-specific positron emission tomography model. J Clin Endocrinol Metab. 2003 Mar;88(3):1271-9.

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Books and book chapters

• None published this year.

Abstracts

• Allister E, James A, Mamo JCL, Barrett PHR, Soares M, Watts GF. The acute effects of insulin on chylomicron metabolism in viscerally obese men. Athero Suppl 003; 4: 129.
• Barrett PHR, Ji J, Johnson AG, Serone A, Loehrer F, Watts GF. Differential effects of Fenofibrate and Atorvastatin on HDL apoAII Transport in the Metabolic Syndrome. Athero Suppl 2003; 4: 231.
• Bertoldo A, Sparacino G, Cobelli C. Population approaches for quantitative PET imaging. PAGE (Population Approach Group Europe) Annual Meeting, Verona, Italy, 2003
• Bies RR, Lotrich FE, Smith G, Muldoon M. Pollock BG. Pharmacokinetics of citalopram after IV infusion. Clin Pharmacol Ther 2003(73)2:P71.
• Bies RR, Pollock BG, Sale ME. A comparison of binary tree and genetic algorithm covariate search strategies. Population Approach Group Europe Annual Meeting, Verona, Italy 2003.
• Bies RR, Sale ME, Smith G, Muldoon M, Lotrich FE, Pollock BG. Outcome of NONMEM analysis depends on modeling strategy. Clin Pharmacol Ther 2003;73:2:P52
• Carey PE, Dalla Man C, Cline GW, Firbank M, English P, Coulthard A, Cobelli C, Taylor R. Acute Suppression of Intra-Organ Fatty Acid Availability Enhances Effective Post-Prandial Glucose Homeostasis Diabetes 52: Supplement 1, 2311-PO, 2003.
• Chan D, Watts GF, Barrett PHR, Sussekov AV. Adipose tissue compartments and insulin resistance in overweight/obese men. Athero Suppl 2003; 4: 125.
• Chan D, Watts GF, Barrett PHR, van Bockxmeer FM. Polymorphism (T400K) in the ATP-Binding Cassette (ABCG8) Transporter Gene Influences the Kinetic of Apolipoprotein B-100 Metabolism. Athero Suppl 2003; 4: 135.
• Corazza S., G. Pillonetto, C. Cobelli, R. Frezza. Numerical approach to skin artifacts correction in stereophotogrammetry. In: Proceedings of the conference of the American Society of Biomechanics: Toledo, OH, USA, September 25-29, 2003
• Dalla Man C, Caumo A, Basu R, Rizza R, Toffolo G, Cobelli C. Validation of the Oral Glucose Minimal Model Insulin Sensitivity Index. Diabetes 52: Supplement 1, 1286-P, 2003.
• Dalla Man C., Caumo A., Basu R., Rizza R., Toffolo G., Cobelli C. Assessment of peripheral insulin sensitivity from an oral glucose test by a new labelled oral minimal model. Diabetologia Vol. 46: Supplement 2, A194, 2003
• Dash RK, Bell BM, Kushmerick MJ, Vicini P. Estimation of Muscle Oxygen Uptake During Muscle Contraction and Recovery Using Deconvolution. BMES 2003 Annual Fall Meeting abstracts # 6.6.3.
• Di Camillo B., R. Sreekumar, L.J. Greenlund, G.Toffolo, C.Cobelli, S.K.Nair. Selection of Insulin Regulated Genes Based on Array Measurement Error. In: Proc. of Genomics of Diabetes and Associated Diseases in the Post Genome Era. - Lille, France, 2003
• Di Camillo B., R. Sreekumar, L.J. Greenlund, G.Toffolo, C.Cobelli, S.K.Nair. Exploiting Intensity Dependent Noise Knowledge To Select Differentially Expressed Genes In Time Course Experiments. In: Proc. of Bioinformatics: From Predictive Models To Inference, Oxford, UK, 2003
• Feng Y, Pollock BG, Roose S, Kirshner MA, Lotrich FE, Kupfer DJ, Bies RR. Mixed Effects Pharmacokinetic Modeling Of An Age Effect On Citalopram Disposition AAPS PharmSci 2003;5:4:M1063.
• Gallo JM, Orlansky A, Vicini P, Bookman M, Guo P. Pharmacokinetic model-predicted anticancer drug concentrations in human tumors. Proceedings of the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, p 237-238, 2003.
• Gardner JC, Zierhut ML, Gardner GC, Mease P, Sharp JT, Spilker ME, Vicini P. Changes in MRI measures of Synovial Vascularity in the RA wrist at 1-2 months following Initiation of anti-TNFá and Methotrexate Therapy. ACR / ARHP 67th Annual Scientific Meeting, Orlando, FL, October 23-28, 2003.
• Hooker AC, Dodds M, Vicini P. Simultaneous Population D-Optimal Designs of Pharmacokinetic-Pharmacodynamic Experiments. PAGE (Population Approach Group Europe) Annual Meeting, Verona, Italy, 2003 (http://www.page-meeting.org).
• James A, Mamo JCL, Barrett PHR, Hamilton S, Watts GF. The effect of insulin sensitisers on postprandial metabolism in obese, insulin resistant subjects. Athero Suppl 2003; 4: 128.
• Ji J, Barrett PHR, Johnson AG, Chan D, Serone A, Loehrer F, Watts GF. Kinetics of HDL apoAI and apoAII in the Metabolic Syndrome. Athero Suppl 2003; 4: 232.
• Kerwin W, Hooker A, Spilker M et al. Quantitative magnetic resonance imaging analysis of neovasculature volume in carotid atherosclerotic plaque. Circulation 107 (6): 851-856 Feb 18 2003.
• Krssak RM, Brehm A, Bernroider E, Dalla Man C, Nowotny P, Cobelli C, Shulman GI, Waldhäusl W, Roden M. Defect of Postprandial Hepatic Glucose Methabolism in Type2 Diabetes Mellitus. Proceedings of the 11th Sc. Meeting of Int Soc Magn Reson Med, pp 1479 (Toronto, May 2003).
• Matthan N, Jalbert S, Dolnikowski GG, Welty FK, Barrett PHR, Schaefer EJ, Lichtenstein AH. Dietary hydrogenated fat decreases LDL apoB100 catabolism and increases HDL apoAI catabolism in hyperecholesterolemic women. Circulation Suppl. 2003; 108: 784.
• Nolin TD, Gastonguay MR, Bies RR, Matzke GR, Bernardo JF, Aslam M, Frye RF. Population pharmacokinetic model of chlorzoxazone and 6-hydroxychlorzoxazone in renal failure: Impact of patient covariates on CYP 2E1 activity. Clin Pharmaol Ther 2003(73)1:P80
• Pillonetto, G. Bayesian deconvolution of functions in Reproducing Kernel Hilbert Spaces using MCMC techniques. In: Book of abstracts of the 21st IFIP TC 7 Conference on System Modeling and Optimization: Sophia Antipolis, France, July 21-25, 2003
• Rizza R., Basu R., Dalla Man C., Basu A., Powel C., Toffolo G., Cobelli C. Effects of Age and Gender on Postprandial Glucose Metabolism. Diabetologia Vol. 46: Supplement 2, A203, 2003
• Sanchez-Cabo F, DiCamillo B, Hackl H, Gann G, Thallinger G, Hubbard S, Wolkenhauer O, Trajanoski Z. MICO: Inferring transcriptional networks from microarray data. In: Proceedings of Molecular medicine beyond differentially expressed genes: Systematic approaches and mathematical modeling. December 5-6, 2003 Heidelberg, Germany
• Sunehag A, G Toffolo, D Bier, M Haymond. In contrast to their non obese counterpart, obese adolescents increase insulin secretion but not insulin sensitivity in response to a high carbohydrate diet. Diabetes 52, Supplement 1, A304, 2003
• Visich JE, Cheong J, Zuckerman L A, Ponce R, Pederson S, Dodds MG, Vicini P, Rogge M. Pharmacokinetics of recombinant human FXIII in cynomolgus monkeys. Journal of Thrombosis and Haemostasis 2003; 1 Supplement 1 July: abstract number P0301.
• Visich JE, Reynolds TC, Byrnes-Blake K, Zuckerman LA, Dodds MG, Vicini P, Rogge M. Phase I Pharmacokinetics of a Single Dose of Recombinant Factor XIII Administered to Healthy Volunteers. Blood: 102(11), ASH Abstract #1104, 2003.
• Watrous MJ, Bell BM, Dodds MG, Hooker A, Vicini P. Robust optimal design for biological systems via the Laplace approximation. In: Final Program and Abstracts of the SIAM Conference on Computational Science and Engineering: San Diego, CA, February 10-13, 2003. pp. 147-148. [T]
• Williams KV, Bertoldo A, Cobelli C, Kelley DE. Weight Loss Induced Plasticity of Skeletal Muscle Glucose Transport and Phosphorylation in the Insulin Resistance of Obesity and Type 2 Diabetes. Diabetes 52: Supplement 1, 223-OR, 2003.