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2004 Publications
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Papers
- Bell BM, Pillonetto G. Estimating
parameters and stochastic functions of one variable using nonlinear
measurement models. Inverse Problems 20(4): 627-646,
2004.
- Bertoldo A, Sparacino G, Cobelli C. "Population" approach
improves parameter estimation of kinetic models from dynamic PET
data. IEEE Trans Med Imaging. 2004 Mar;23(3):297-306.
- Bies RR, Feng Y, Lotrich FE, Kirshner MA, Roose S, Kupfer DJ, Pollock BG.Utility of sparse concentration sampling for citalopram in elderly clinical
trial subjects. J Clin Pharmacol. 2004 Dec;44(12):1352-9.
- Calvo R, Telletxea S, Leal N, Aguilera L, Suarez E, De La Fuente L,
Martin-Suarez A, Lukas JC. Influence of formulation on propofol
pharmacokinetics and pharmacodynamics in anesthetized patients. Acta
Anaesthesiol Scand. 2004 Sep;48(8):1038-48.
- Chan DC, Barrett HP, Watts GF. Dyslipidemia in visceral obesity: mechanisms,
implications, and therapy. Am J Cardiovasc Drugs. 2004;4(4):227-46. Review.
- Chan DC, Barrett PH, Watts GF. Lipoprotein
transport in the metabolic syndrome (Part I): Methodological aspects
of stable isotope kinetic studies. Clin Sci (Lond).
2004 Jun 30 [Epub ahead of print]
- Chan DC, Barrett PH, Watts GF. Lipoprotein
transport in the metabolic syndrome (Part II): Pathophysiological
and interventional studies employing stable isotopy and modelling
methods. Clin Sci (Lond). 2004 Jun 30 [Epub ahead of
print]
- Chan DC, Barrett PHR, Watts GF. Lipoprotein kinetics
in the metabolic syndrome: pathophysiological and therapeutic lessons
from stable isotope studies. Clin Biochem Rev 2004; 25: 31-48.
- Chan DC, Watts GF, Barrett PH, Whitfield AJ, van Bockxmeer FM. ATP-binding
cassette transporter G8 gene as a determinant of apolipoprotein B-100
kinetics in overweight men. Arterioscler Thromb Vasc Biol. 2004
Nov;24(11):2188-91. Epub 2004 Aug 26.
- Chan DC, Watts GF, Sussekov AV, Barrett PH, Yang Z, Hua
J, Song S.. Adipose
tissue compartments and insulin resistance in overweight-obese Caucasian
men. Diabetes Res Clin Pract. 2004 Feb;63(2):77-85.
- Chen X, Bies RR, Ramanathan RK, Zuhowski EG, Trump DL, Egorin MJ. Population
pharmacokinetic analysis of 17-(allylamino)-17-demethoxygeldanamycin (17AAG)
in adult patients with advanced malignancies. Cancer Chemother Pharmacol.2004 Oct 19;
- Dalla Man C, Caumo A, Basu R, Rizza R, Toffolo G, Cobelli
C.. Minimal
model estimation of glucose absorption and insulin sensitivity during
an oral test: validation of a nontracer against a tracer method. Am J Physiol Endocrinol Metab.2004 May 11 [Epub ahead of print]
- Dodds MG, Vicini P. Assessing convergence of Markov chain Monte Carlo
simulations in hierarchical Bayesian models for population pharmacokinetics. Ann Biomed Eng. 2004 Sep;32(9):1300-13.
- Foracchia M, Hooker A, Vicini P, Ruggeri A. PopED,
a software for optimal experiment design in population kinetics. Comput Methods Programs Biomed. 2004 Apr;74(1):29-46.
- Gallo JM, Vicini P, Orlansky A, Li S, Zhou F, Ma J, Pulfer S, Bookman MA,
Guo P. EstimatingPharmacokinetic model-predicted anticancer drug concentrations in
human tumors. Clin Cancer Res. 2004 Dec 1;10(23):8048-58.
- Geiss HC, Bremer S, Barrett PH, Otto C, Parhofer KG. In
vivo metabolism of LDL-subfractions in patients with heterozygous
familial hypercholesterolemia on statin therapy: rebound analysis
of LDL subfractions following LDL-apheresis. J Lipid Res.. 2004 Jun 1 [Epub ahead of print]
- Hoffman RP, Vicini P, Cobelli C. Pubertal changes in HOMA and QUICKI:
relationship to hepatic and peripheral insulin sensitivity. Pediatr
Diabetes. 2004 Sep;5(3):122-5.
- Karunajeewa HA, Ilett KF, Dufall K, Kemiki A, Bockarie M,
Alpers MP, Barrett PH, Vicini P, Davis TM. Disposition
of Artesunate and Dihydroartemisinin after administration of Artesunate
suppositories in children from Papua New Guinea with uncomplicated
malaria. Antimicrob Agents Chemother. 2004 Aug;48(8):2966-2972.
- Krssak M, Brehm A, Bernroider E, Anderwald C,
Nowotny P, Dalla Man C, Cobelli C, Cline GW, Shulman GI, Waldhäusl
W, Roden M. Alterations
in postprandial hepatic glycogen metabolism in type 2 diabetes. Diabetes
53:3048-56, 2004.
- Magni P, Sparacino G, Bellazzi R, Toffolo GM, Cobelli C. Insulin
minimal model indexes and secretion: proper handling of uncertainty
by a Bayesian approach. Ann Biomed Eng. 2004 Jul;32(7):1027-37.
- Matthan NR, Welty FK, Barrett PH, Harausz C, Dolnikowski
GG, Parks JS, Eckel RH, Schaefer EJ, Lichtenstein AH. Dietary
hydrogenated fat increases high-density lipoprotein apoA-I catabolism
and decreases low-density lipoprotein apoB-100 catabolism in hypercholesterolemic
women. Arterioscler Thromb Vasc Biol.
2004 Jun;24(6):1092-7. Epub 2004 Apr 15.
- O'Brien KD, Lewis K, Fischer JW, Johnson P, Hwang JY, Knopp EA, Kinsella MG,
Barrett PH, Chait A, Wight TN. Smooth muscle cell biglycan overexpression
results in increased lipoprotein retention on extracellular matrix:
implications for the retention of lipoproteins in atherosclerosis.Atherosclerosis. 2004 Nov;177(1):29-35.
- Pillonetto G, Bell BM. Deconvolution
of nonstationary physical signals: a smooth variance model for insulin
secretion rate.
Inverse Problems 20(2): 367-383, 2004.
- Prinsen BHCMT, Ton J. Rabelink TJ, Romijn JA, Bisschop PH,
de Barse MMJ, de Boer J, van Haeften TW, Barrett PHR, Berger R, de
Sain-van der Velden MGM. A
broad based metabolic approach to study VLDLapoB100 metabolism in
patients with ESRD and patients treated with peritoneal dialysis.
Kidney Intl 2004; 65: 1064-1075.
- Qiu R, Yao A, Vicini P, McDonald GB, Batchelder AL, Bouvier ME, Cole SL,
Slattery JT. Diminishing the risk of nonrelapse mortality in hematopoietic
stem cell transplantation: Prediction of exposure to the cyclophosphamide
metabolite carboxyethylphosphoramide mustard. Clin Pharmacol Ther. 2004
Sep;76(3):270-80.
- Tannock LR, Little PJ, Tsoi C, Barrett PH, Wight TN, Chait
A. Thiazolidinediones
reduce the LDL binding affinity of non-human primate vascular cell
proteoglycans. Diabetologia.2004 May;47(5):837-43.
Epub 2004 Apr 08.
- Vicini P, Westhagen A. Quantitative Modeling And Software Approaches To The
Analysis Of Complex Multilevel Systems. Proceedings of the 55th
International Astronautical Congress of the IAF, October 2-8, 2004,
Vancouver, BC, Canada, IAC-04-IAF-G.1.04.
- Welty FK, Lichtenstein AH, Barrett PH, Dolnikowski GG, Schaefer
EJ. Interrelationships
Between Human Apolipoprotein A-I and Apolipoproteins B-48 and B-100
Kinetics Using Stable Isotopes. Arterioscler Thromb Vasc
Biol. 2004 Jul 8 [Epub ahead of print]
- Whitfield AJ, Barrett PH, van Bockxmeer FM, Burnett JR. Lipid disorders and
mutations in the APOB gene. Clin Chem. 2004 Oct;50(10):1725-32. Epub 2004
Aug 12.
- Whitfield AJ, Barrett PH, Robertson K, Havlat MF, van Bockxmeer FM, Burnett
JR. Liver Dysfunction and Steatosis in Familial Hypobetalipoproteinemia.Clin Chem. 2004 Oct 28; [Epub ahead of print]
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Books and book chapters
- Sparacino G, Pillonetto G, De Nicolao G, Cobelli C. Deconvoluzione per
l'analisi di segnali fisiologici. In: "Metodi Avanzati di Elaborazione di
Segnali Biomedici", S.Cerutti and C.Marchesi, Eds., Patron Editore, Bologna,
Italy, 163-188, 2004.
Abstracts
- Barrett PH. HDL metabolism: a model of LpAI:AII kinetics. 34th KinMet 2004 -
Satellite Symposium on Kinetics and Kinetic Modeling of Lipoprotein, Lipid,
and Sterol Metabolism in Systems Ranging from Human Subjects to Cultured
Cells, May 5, 2004, San Francisco, CA. (http://www.bioinformaticsservices.com/kinmet2004.html)
- Barrett PH. Modeling of Human Apolipoprotein A-I and B Metabolism
(Berman-Zech Award Lecture). 34th KinMet 2004 - Satellite Symposium on
Kinetics and Kinetic Modeling of Lipoprotein, Lipid, and Sterol Metabolism
in Systems Ranging from Human Subjects to Cultured Cells, May 5, 2004, San
Francisco, CA.(http://www.bioinformaticsservices.com/kinmet2004.html)
- Barrett PHR, Ji J, Johnson AG, Serone A, Loehrer F, Watts GF. Fenofibrate
increases HDL LpAI:AII production in men with the metabolic syndrome.
Atherosclerosis Suppl 2004; 5: 47.
- Barrett PHR, Farvid MS, Zilko SR, Allen MC, Chan DC, Watts GF. HDL
apolipoprotein A-I kinetics in the metabolic syndrome: Pooled analysis of
stable isotope studies. Atherosclerosis Suppl 2004; 5: 48.
- Barrett PHR. Lipoprotein kinetics in the metabolic syndrome. XV
International Symposium on Drugs affecting Lipid Metabolism, Venice, October
2004.
(http://www.lorenzinifoundation.org/dalm2004/pag1-20.pdf)
- Barrett PHR, Ji J, Johnson AG, Serone A, Loehrer F, Watts GF. Fenofibrate
increases HDL LpAI:AII production in men with the metabolic syndrome.
Arterio Thromb Vasc Biol 2004; 24: e79.
- Basu A, Dalla Man C, Toffolo G, Basu R, Cobelli C, Rizza
RA. Effect of Type 2 Diabetes on Meal Tolerance and Insulin
Secretion. Diabetes 53 (Supplement 2): A579:2445-P, 2004.
- Basu R, Singh RJ, Chittilpilly EG, Johson MC, Toffolo G, Cobelli C, Rizza R.
Splanchnic cortisol production occurs in humans: evidence for tissue
specific 11-B hydroxyl steroid dehydrogenase type 1 activity. Diabetologia 47, Suppl.1, A597, 2004.
- Baumann EE, Dalla Man C, Cobelli C, Rosenfield RL. Insulin
Sensitivity (Si) by OGTT Minimal Model Assessment Is Low in Hyperandrogenic
Children. Diabetes 53 (Supplement 2): A306:1263-P, 2004.
- Bertoldo A., Price J, Mathis C, Mason S, Holt D, Kelley C, McKolanis T,
Cobelli C, Kelley DE. Glucose transport in human skeletal muscle using
dynamic PET imaging of [11C]-3-O-Methyl-D-glucose. 40th Annual Meeting of
the European Association for the Study of Diabetes, Munich, Germany, 5 - 9
September 2004.
- Bertoldo A, Corazza S, Zanderigo F, Pillonetto G, Cosottini M, Cobelli C.Assessment of Regional Cerebral Blood Flow by Bolus-Tracking MRI Images:
Characterization of the Tissue Residue Function Using Nonlinear Stochastic
Regularization Method. Proceedings of MEDICON 2004 - Mediterranean
Conference on Medical and Biological Engineering, Island of Ischia, Naples,
Italy, July 31 - August 5 2004.
- Bolitho P, Chan DC, Barrett PHR, Watts GF. Effect of atorvastatin and fish
oil on HDL apolipoprotein A-I kinetics in the metabolic syndrome.
Atherosclerosis Suppl 2004; 5: 48.
- Bovo V, Bertoldo A, Price JC, Frank GK, Kaye WH, Cobelli C. Examination of a
Three-Tissue Compartment Model for [11C]WAY-100635: Insight and Comparison
with a Two-Tissue Compartment Model. Neuroimage, 22 (Suppl.2): T65, 2004.
- Campioni M, Toffolo G, Rizza R, Cobelli C. Estimation of hepatic insulin
extraction during IM-IVGTT: individual vs. standard kinetic parameters.
MEDICON 2004, Mediterranean Conference on Medical and Biological
Engineering, Naples, Italy, July 31-August 5, 2004.
- Campioni M, Toffolo G, Shuster LT, Service FJ, Rizza RA,
Cobelli C. Incretin Factors Potentiate Beta-Cell Sensitivity
to Glucose as Well as to Its Rate of Change: OGTT and Matched Intravenous
Study. Diabetes 53 (Supplement 2): A320:1323-P, 2004.
- Corazza S, Sparacino G, Maran A, Cobelli C. Prediction method to alert
patient hyper/hypo-glycaemic events from continuous glucose monitoring. In:
Proceedings of the Diabetes Technology Meeting, October 28-30, 2004,
Philadelphia, 2004.
- Dalla Man C, Basu R, Toffolo G, Rizza RA, Cobelli C. Assessment
of Hepatic Insulin Sensitivity and Glucose Effectiveness. Diabetes
53 (Supplement 2): A321:1328-P, 2004.
- Dalla Man C, Cobelli C,Basu R, Rizza R, Toffolo G. Novel Assessment of
Glucose and Insulin Control on Glucose Production During a Meal. Proceedings
of MEDICON and HEALTH TELEMATICS 2004 Conference, Naples, Italy, July
31-August 5, 2004.
- Dalla Man C, Toffolo G, Caumo A, Rizza RA, Polonsky KS, Cobelli
C. 120 min - 7 Samples OGTT/MEAL Minimal Model Simultaneous
Assessment of Insulin Sensitivity and Beta-Cell Responsivity: Validation
Against 300/420 min Protocols. Diabetes 53 (Supplement 2): A321:1327-P,
2004.
- DiCamillo B, Sanchez-Cabo, Nair SK, Toffolo G, Cobelli C. Identification of
Gene Regulatory Modules Using Entropy And Mutual Information. In:
Proceedings of MEDICON Mediterranean Conference on Medical and Biological
Engineering, Naples, July 31-August 5, 2004.
- DiCamillo B, Toffolo G, Cobelli C, Nair SK. Selection
of Insulin Regulated Gene Expression Profiles Based on Intensity-Dependent
Noise Distribution of Microarray Data. In: Proceedings of BITS2004:
Bioinformatics Italian Society Meeting, March 26-27 2004, Padova, Italy
- Dodds MG, Hooker AC, Vicini P. Robust Population
Pharmacokinetic Experiment Design. PAGE (Population Approach Group
in Europe) Thirteenth Meeting, 17-18 June, 2004, Uppsala, Sweden. (http://www.page-meeting.org/)
- Dodds MG, Vicini P, Visich JE. A Population PK
Model for Recombinant Factor XIII in Healthy Volunteers. PAGE (Population
Approach Group in Europe) Thirteenth Meeting, 17-18 June, 2004, Uppsala,
Sweden. (http://www.page-meeting.org/)
- Farvid MS, Ng WK, Chan DC, Barrett PHR, Watts GF. Adiponectin as a
determinant of VLDL apoB kinetics in men. Atherosclerosis Suppl 2004; 5: 30.
- Farvid MS, Ng WK, Chan DC, Barrett PHR, Watts GF. Association between plasma
adiponectin levels and adipose tissue compartments in men. Atherosclerosis Suppl 2004; 5: 50.
- Feng Y, Bies RR, Bobek MB, Kane SL. Population
pharmacokinetics analysis of patients receiving enoxaparin by continuous
intravenous infusion. Clinical Pharmacology and
Therapeutics 75(2):
P30, PI-102, 2004.
- Feng Y, Pollock BG, Reynolds C, Bies RR. Paroxetine pharmacokinetics in
geriatric patients. AAPS PharmSci Abstract M1116, 2004.
- Hooker A, Dodds MG, Vicini P. Evaluating the predictive
power of the Fisher information matrix in population optimal experimental
design. PAGE (Population Approach Group in Europe) Thirteenth Meeting,
17-18 June, 2004, Uppsala, Sweden. (http://www.page-meeting.org/)
- Kee P, Rye KA, Moorehouse L, Barrett PHR, Barter PJ. The effects of
cholesteryl ester transfer protein (CETP) inhibition on the metabolism of
cholesteryl esters in high density lipoproteins: Insights into reverse
cholesterol transport. Cardiac Society of Australia and New Zealand
Scientific Session, August 4, 2004.
- Krudys K, Vicini P. Validation of an Integrated
Model of Peripheral and Liver Regulation of Glucose Kinetics during
the IVGTT. Diabetes 53 (Supplement 2): A373:1555-P, 2004.
- Lewis LD, Rosner GL, Miller AA, Egorin MJ, Relling H, Kastrissios H, Bies R,
Ratain MJ. CALGB9871. The pharmacokinetics and pharmacodynamics of docetaxel
(DCTX) in Caucasian and African American patients with solid tumors. ASCO
2004 New Orleans LA
- Maran A, Sparacino G, Pavanini A, Corazza S, Crepaldi M, Poscia A, Avogaro
A, Cobelli C. On-line glucose prediction from continuous monitoring data and
prevention of hyper/hypo-glycaemic events, Diabetologia
47, Suppl.1,
pag.A317, 2004.
- Maran A, Sparacino G, Pavanini A, Corazza S, Crepaldi C, Tiengo A, Avogaro
A, Cobelli C. Predizione dei valori glicemici mediante monitoraggio in
continuo del glucosio. Atti del XX Convegno della Società Italiana di
Diabetologia, Roma, 26-29 maggio 2004, 2004.
- Maran A, Sparacino G, Pavanini A, Crepaldi C, Poscia A, Tiengo
A, Avogaro A, Cobelli C. Glucose Prediction from Continuous
Subcutaneous Monitoring Data. Diabetes 53 (Supplement 2): A105:445-P,
2004.
- Moresco RM, Messa C, Tagliavini F, Panzacchi A, Giovagnoli MR, Matarrese M,
Pietra L, Bertoldo A, Rizzo G, Giaccone G, Di Fede G, Mattioli C, Cobelli C,
Fazio F, Bugiani O. Microglial activation in Creutzfeldt-Jakob disease
(CJD): a PET [C-11]PK11195. Neuroimage, 22 (Suppl.2): T86, 2004.
- Ng WK, Chan DC, Susekov A, Watts GF, Barrett PHR. Chylomicron remnant
kinetics in the metabolic syndrome measured with stable isotopy.
Atherosclerosis Suppl 2004; 5: 57.
- Pierce CH, Dills RR, Freidhoff J, Deneen A, La Casse A, Morgan MS.Toxicokinetics of MTBE in Human Subjects. 2004 5th Annual Environmental and
Occupational Health conference, July 11-13, 2004, Minneapolis, MN. (http://www.asph.org/document.cfm?page=847)
- Silber H, Stetina P, McHugh B, Gieschke R, Frey N, Vicini P, Simonsson USH,
Karlsson MO. A disease model for the regulation of the glucose-insulin
system. Proceedings of PKUK 2004, 17th - 19th November 2004, Belfast,
Northern Ireland, UK, p. 32.
- Silber H, Stetina P, McHugh B, Gieschke R, Frey N, Vicini
P, Simonsson USH, Karlsson MO. A disease model for the regulation
of the glucose-insulin system. PAGE (Population Approach Group in
Europe) Thirteenth Meeting, 17-18 June, 2004, Uppsala, Sweden. (http://www.page-meeting.org/)
- Sparacino G, Maran A, Pavanini A, Corazza S, Crepaldi C, Avogaro A, Cobelli
C. On-line glucose prediction from continuous monitoring subcutaneous
sensor, In: Proceedings of the X MEDICON Mediterranean Conference on Medical
and Biological Engineering, Naples, 31 July - 5 August, 2004.
- Telford DE, Lipson SM, Barrett PHR, Sutherland BG, Aebi JD, Morand OH, Huff
MW. A novel inhibitor of oxidosqualene cyclase decreases VLDL and LDL
apoB100 through decreased VLDL production and enhanced LDL catabolism. XV
International Symposium on Drugs affecting Lipid Metabolism Meeting, Venice,
October 2004.
(http://www.lorenzinifoundation.org/dalm2004/pag1-20.pdf)
- Toffolo G, Dalla Man C, Basu R, Rizza R, Cobelli C. Assessment of
postprandial glucose metabolism: conventional vs triple tracer method.
Diabetologia 47, Suppl.1, A590, 2004.
- Vicini P. Model-based biomarkers. AAPS Workshop on Clinical Biomarkers in
Drug Development: Efficacy Assessment, Pharmacokinetics/Pharmacodynamics and
Regulatory Insights, November 5 - 6, 2004, Holiday Inn Inner Harbour,
Baltimore, MD. (http://www.aapspharmaceutica.com/meetings/meeting.asp?id=38)
- Vicini P. Designing Model-Based Probes: Accomplishments and Challenges in
Understanding Glucose Homeostasis. Proceedings of PKUK 2004, 17th - 19th
November 2004, Belfast, Northern Ireland, UK, p. 5-6.
- Watts GF, Farvid MS, Zilko SR, Allen MC, Chan DC, Barrett PHR. Kinetic
determinants of plasma HDL apoA-I concentration in normolipidemic healthy
subjects: Analysis of stable and radioactive isotope studies.
Atherosclerosis Suppl 2004; 5: 66.
- Whitfield AJ, Crawford G, Barrett PH, Robertson K, Hegele
RA, Tran K, Yao ZM, van Bockxmeer FM, Burnett JR. A novel
nontruncating APOB gene mutation, L343V, causes familial hypobetalipoproteinemia. Arteriosclerosis
Thrombosis and Vascular Biology 24 (5): E55 P314
May 2004
- Whitfield AJ, Crawford G, Barrett PHR, Robertson K, Hegele RA, Tran K, Yao
Z, van Bockxmeer FM, Burnett JR. A novel non-truncating APOB gene mutation,
L343V, causes familial hypobetalipoproteinaemia. Atherosclerosis Suppl 2004;
5: 78.
- Whitfield AJ, Barrett PHR, Robertson K, van Bockxmeer FM, Burnett JR. Liver
dysfunction in a man with HFE C282Y/H63D, a1-antitrypsin PiZ, and familial
hypobetalipoproteinaemia. Atherosclerosis Suppl 2004; 5: 158.
- Whitfield AJ, Crawford G, Barrett PHR, Robertson K, Hegele RA, Tran K, Yao
Z, van Bockxmeer FM, Burnett JR. A Novel Nontruncating APOB Gene Mutation,
L343V, Causes Familial Hypobetalipoproteinemia. Arterio
Thromb Vasc Biol
2004; 24: e105.
- Zanderigo F, Bertoldo A, Pillonetto G, Cosottini M, Cobelli C. Nonlinear
stochastic regularization to characterize tissue residue function from
bolus-tracking MRI images. ISMRM Workshop on Quantitative Cerebral Perfusion
Imaging using MRI: A Technical Perspective 21-23 March 2004, San Servolo,
Venice, Italy.
- Zierhut ML, Peterson MC, Gastonguay MR, Martin SW, Vicini
P, Bekker PJ, Holloway D, Leese PT. Development and Evaluation
of a Population PK/PD Model for Fc-OPG in Healthy Postmenopausal
Women. PAGE (Population Approach Group in Europe) Thirteenth Meeting,
17-18 June, 2004, Uppsala, Sweden. (http://www.page-meeting.org/)
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