Research & Development

Software

System for Population Kinetics Analysis (SPK)
The Resource Facility for Population Kinetics is pleased to provide access to its System for Population Kinetic Analysis.

A3G (Automated Analysis of Axon Growth)
A3G is a set of MATLAB programs that automatically identifies and records the axon tip position in each phase-contrast image of a time-lapse series with minimal user involvement. The software outputs several quantitative measures of axon growth, and allows users to develop custom measurements.

PopED (POPulation Experiment Design)
A standalone software tool that performs D- and ED-optimality calculations for a series of compartmental models commonly used in pharmacokinetics. This release is intended for Windows based machines and was developed using the Windows 2000 operating system and in the O-Matrix programming environment.

Population 3-Compartment Model (POP3CM)
POP3CM is a prototype population analysis program. The program uses a graphical user interface to allow population analysis of repeated measurements with the analysis of a three compartmental model.

Benchmark Software Tools
List of links to the currently available benchmark software tools for population kinetic analysis.

Modeling Theory

Accessing Technical Reports:

In order to access the technical reports, you will need to fill out a short questionaire.

• Click on the report title from the list below. Fill out the form.
• Clicked the submit button to access the report.
• Each request for a report will require filling out a form.

Original Technical Reports

Bell, BM and A. Schumitzky. A generalization of the Gauss-Newton
method that solves extended least-squares problems (546K PDF*). Resource Facility for Population Kinetics Technical Report
TR-1999-1.

Bell, B.M. and A. Schumitzky. Asymptotic Properties of Extended Least
Squares Estimators (525K PDF*). Resource Facility for Population Kinetics Technical Report TR-1999-2.

Bell, BM. The importance of marginal likelihood estimation applied to
mixed-effects modeling (125K PDF*). Resource Facility for Population Kinetics Technical Report TR-2003-1.

Vicini, P. Sparse data and complex models: dealing with unidentifiability (336K PDF*). Resource Facility for Population Kinetics Technical Report TR-2001-1.

Grisan, E and Vicini, P. An Individual Estimation Comparison of SAAM II and NONMEM (3.1MB PDF*). Resource Facility for Population Kinetics Technical Report TR-2001-2.

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